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Synthèses et études structurales de nouveaux peptoïdes et de leurs conjugués avec des métallophtalocyanines

Abstract : Peptoids (N-substituted glycine oligomers) are an important class of foldamers capable of adopting a range of unique secondary structures based on the cis/trans conformation of their constituting main chain tertiary amide bonds. The folding mode of peptoid oligomers in orderly secondary structures and their conformational stability are closely related to their sequence. In this context, my work has focused on the development of new peptoid oligomer sequences as chemical platforms for the topological presentation of photosensitizer agents (phthalocyanin/porphyrin). A first important part of the thesis concerned an in-depth study of the conformation of oligopeptoids. We have developed Polyproline I (PPI) helical structured peptoids with high conformational stability from chiral and achiral aliphatic units. Helical peptoids have been conjugated to one or two macrocyclic photosensitizers. In a second part, cyclic peptoids with functionalpendant side chains have been conceived for the presentation of photosensitizers. Various backbones (α, β and α,β-peptoid) were considered to obtain conjugated molecules displaying diverse ring sizes and topologies.
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Submitted on : Monday, July 25, 2022 - 5:06:42 PM
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Maha Rzeigui. Synthèses et études structurales de nouveaux peptoïdes et de leurs conjugués avec des métallophtalocyanines. Chimie organique. Université Clermont Auvergne [2017-2020]; Université de Carthage (Tunisie), 2020. Français. ⟨NNT : 2020CLFAC025⟩. ⟨tel-03738073⟩



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