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Drying droplets as a template for multi-component solid particles : experimental study and modeling at the droplet scale

Abstract : Liquid droplets are one of the major means of generation of solid particles with controlled. These templates are encountered with a variety of industrial processes, among them, spray drying. These tailored structures would meet the demand for particles with controlled properties, like improved kinetics, sustained release or controlled reactivity. The major scientific obstacle is the detailed description of the components distribution inside the droplet during drying, besides prediction of the final particle morphology. An experimental/modeling approach is undertaken in this thesis to understand how the drying conditions and the liquid formulation impact the final structure of the powders. The drying systems studied were sucrose-dextran and lactose-whey protein isolate aqueous solutions. The experimental work was firstly carried out at the lab-scale spray-dryer giving a reference picture of the possible particle morphologies for the drying systems. An experimental set-up was designed and developed to suspend a liquid droplet by a filament, from which the droplet mass variation over time could be accurately measured, giving fundamental insight into the drying process and allowing the analysis of the modification of the solid structures. A novelty explored at the droplet scale with an acoustic levitator was to apply an in situ Raman spectroscopy to assess the evolution of the spatial distribution of two components in drying droplets. Finally, a 2-D droplet drying model using Computational Fluid Dynamics was developed for allowing the assessment of the spatial distribution of the droplet components under a convective drying, until the formation of a crust. A sensitivity analysis was performed in order to show the influence of the experimental conditions on the drying kinetics and the component spatial distribution.
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Submitted on : Sunday, January 23, 2022 - 1:01:10 AM
Last modification on : Wednesday, April 6, 2022 - 5:14:08 PM
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  • HAL Id : tel-03540093, version 1


Roger Williams de Souza Lima. Drying droplets as a template for multi-component solid particles : experimental study and modeling at the droplet scale. Chemical and Process Engineering. Ecole des Mines d'Albi-Carmaux, 2020. English. ⟨NNT : 2020EMAC0003⟩. ⟨tel-03540093⟩



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