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Theses

Implants se formant in-situ pour le traitement de la parodontite

Abstract : Periodontal diseases are highly prevalent and widely spread in all human populations. Their consequences are multiples, strongly impacting general quality of life, general health and represent also a global economic burden. They are known to be triggered by a bacterial infection followed by an inadequate inflammatory body response. These mechanisms result in the destruction of the supporting tissues of the tooth (gingiva, ligament and alveolar bone), finally leading to tooth lost. Moreover, periodontal health status has been shown to be correlated with various other conditions and it is believed to worsen other systemic conditions like diabetes mellitus for example. Gold standard treatment of periodontitis is a procedure called scaling and root planning (SRP), consisting of a subgingival mechanical removal of dental plaque and/or calculus. In clinical practice, systemic treatments such as antibiotics are often added to SRP, causing various side effects, without being particularly optimal. Thus, the need to improve the management of periodontitis can be met by developing local drug delivery systems. The aim of this work was to develop and physico-chemically characterise an in-situ forming implant (ISFI). This particular drug delivery system (DDS) is a liquid formulation that will form a solid implant upon injection into the periodontal pocket, releasing two active pharmaceutical ingredients at a controlled release rate. In order to avoid the rise of bacterial resistances against antibiotics, this specific DDS is loaded with antiseptic drugs (e.g chlorhexidine). Secondly, to promote periodontal wound healing, an anti-inflammatory agent (e.g. ibuprofen) is added to the formulation. This work will firstly describe the state of the art regarding these DDSs, with an emphasis on ISFIs. Then, the experimental section will describe the formulations and methods used to characterize the resulting implants. The effects of the formulation parameters on the resulting physico-chemical properties of the systems and in particular the release kinetics will be discussed with respect to the clinical use requirements for this kind of DDS.
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Submitted on : Friday, January 21, 2022 - 11:57:13 AM
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  • HAL Id : tel-03538815, version 1

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Martin Lizambard. Implants se formant in-situ pour le traitement de la parodontite. Médecine humaine et pathologie. Université de Lille, 2019. Français. ⟨NNT : 2019LILUS068⟩. ⟨tel-03538815⟩

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