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Etude sur le changement de type sexuel et les cassures chromosomiques chez Candida glabrata

Abstract : Mating-type switching is one of the strategies developed by fungi to promote sexual reproduction and propagation. This mechanism enables one haploid cell to give rise to a cell of the opposite mating-type so that they can mate. It has been extensively studied in the sexual yeast Saccharomyces cerevisiae but little is known about why the mating-type switching components have been conserved in species like Candida glabrata, in which neither sexual reproduction nor mating-type switching is observed. We have previously shown that mating-type switching can be triggered, in C. glabrata, by expression of the endonuclease responsible of this mechanism in S. cerevisiae, but this leads to massive cell death. In this work, we studied the link existing between mating-type switching and cell death in C. glabrata.
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https://tel.archives-ouvertes.fr/tel-03193616
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Submitted on : Thursday, April 8, 2021 - 11:19:09 PM
Last modification on : Saturday, April 10, 2021 - 3:30:09 AM

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Laetitia Maroc. Etude sur le changement de type sexuel et les cassures chromosomiques chez Candida glabrata. Biologie moléculaire. Université Paris-Saclay, 2021. Français. ⟨NNT : 2021UPASL008⟩. ⟨tel-03193616⟩

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