Skip to Main content Skip to Navigation
Theses

Le peptide NFL-TBS, 40-63 dérivés des neurofilaments : Agents thérapeutique prometteur pour cibler et manipuler les cellules souches neurales et les cellules de glioblastomes

Abstract : The Iaboratory discovered the presence of tubulin binding sites (TBS) on intermediate filaments, like on the neurofilaments (NF) that are specifically expressed by neurons. The NFL-TBS.40-63 peptide, which corresponds to the sequence of TBS on the light subunit of NF, has showed an anti-glioblastoma property in vitro and in vivo, without effect on surrounding healthy cells (neurons and astrocytes). Moreover, it induces the differentiation and maturation of oligodendrocyte precursors without impacting the viability of these cells. Our studies during the PhD, allowed us to exploit the NFL-TBS.40-63 peptide as a possible therapeutic agent for regenerative medicine. Indeed, we showed that the peptide penetrates passively in neural stem cells (NSCs) in vitro and in vivo, and it is not toxic for cells. After several days with the peptide, the "stem" cell properties of cells, including the capacity to proliferate and self-renew, diminish and the cells differentiate into more mature cells.These data indicate that the NFL-TBS.40-63 peptide could be a promising therapeutic agent to target endogenous brain NSCs in neurodegenerative disorders to stimulate the differentiation of these cells.
Document type :
Theses
Complete list of metadatas

https://tel.archives-ouvertes.fr/tel-02612632
Contributor : Abes Star :  Contact
Submitted on : Tuesday, May 19, 2020 - 1:12:15 PM
Last modification on : Tuesday, May 19, 2020 - 5:38:17 PM

File

theseKBARREAU.pdf
Files produced by the author(s)

Identifiers

  • HAL Id : tel-02612632, version 1

Citation

Kristell Barreau. Le peptide NFL-TBS, 40-63 dérivés des neurofilaments : Agents thérapeutique prometteur pour cibler et manipuler les cellules souches neurales et les cellules de glioblastomes. Médecine humaine et pathologie. Université d'Angers; Université de Liège, 2017. Français. ⟨NNT : 2017ANGE0087⟩. ⟨tel-02612632v1⟩

Share

Metrics

Record views

17

Files downloads

1