Contribution à la réalisation d’un dispositif multimodal pour l’imagerie de la moelle épinière

Abstract : This thesis focuses on the instrumentation of the SC, through the development of an experimental device. It uses the Diffuse Optical Imaging (DOI) technique to quantify the local variations of blood flow. For this purpose, several prototypes were designed and used during animal experiments. An optical characterisation was performed on SC samples, ex vivo and in vivo. We built up on this information, representing a first for the state of art, to establish guidelines for the development of the embedded device in the hostile biological environment. The feasability of the functional monitoring with DOI in the big animal (FBM pig) is now proven. The design methodology is addressed in order to highlight the interdependances between the measurement and the system. The results are very promising. They open a new path of exploration, complemen- tary to the ones in everyday medical routine. In fine, this approach will be able to give quantitative indicators for the evaluation and the care of medullar pathologies. Destined for hospital praticians first, several purposes may be drawn from this device ranging from orthopedic to vascular surgeries for pets and humans. Researchers may also benefit from such a tool that would help them understand better the SC and its independance regarding the brain.
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Olivier Tsiakaka. Contribution à la réalisation d’un dispositif multimodal pour l’imagerie de la moelle épinière. Electronique. Sorbonne Université, Université Pierre et Marie Curie, Paris 6, 2018. Français. ⟨tel-02266472⟩

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