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La stimulation transcrânienne par courant continu (tDCS) dans la dépression : ses effets comportementaux et les modifications physiologiques qui les sous-tendent chez l’animal

Abstract : Transcranial direct current stimulation (tDCS) is a non-invasive method with increasing interest for the treatment of several brain disorders, such as major depression. Despite great enthusiasm and promising results, some studies report discrepant findings and no consensus exists for the clinical use of tDCS. The present work aims (i) to determine the most effective stimulation parameters to optimize antidepressant-like effect of tDCS in the forced-swim test in naïve mice and to evaluate the ability of tDCS to reverse depressive-like behaviors in different mouse models of depression, and (ii) to identify some of the mechanisms of action of tDCS to enhance our knowledge on this therapeutic strategy, and thus its clinical effects. We reported that tDCS induced long-lasting antidepressant-like effect, which varied as a function of stimulation settings including number, duration, intensity and polarity of stimulation. Interestingly, the present study also demonstrated that tDCS reduced depressive-like behaviors in different mouse models of depression (UCMS, chronic corticosterone exposure and acute LPS administration). Using cFos immunohistochemistry, we reported that behavioral outcomes induced by a single stimulation were associated with neuronal activation in several brain area involved in emotional regulation. Surprisingly, ten stimulations failed to modulate neuronal activation suggesting the development of other mechanisms behind the long-term effect of repeated tDCS, probably associated with plastic changes in the neuronal response. Interestingly, tDCS have the ability to reverse the UCMS-induced inflammatory response, particularly the number of cells and the polynuclear cell percentage in the spleen. This work brings new insights for a better understanding of the behavioral effects of tDCS and its underlying physiological processes.
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https://tel.archives-ouvertes.fr/tel-02082174
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Submitted on : Friday, March 29, 2019 - 9:32:52 AM
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Tanat Peanlikhit. La stimulation transcrânienne par courant continu (tDCS) dans la dépression : ses effets comportementaux et les modifications physiologiques qui les sous-tendent chez l’animal. Neurosciences [q-bio.NC]. Université Bourgogne Franche-Comté, 2018. Français. ⟨NNT : 2018UBFCE020⟩. ⟨tel-02082174v2⟩

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