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Etude du rôle de STARD3 dans le transport du cholestérol

Abstract : STARD3 is an endosomal sterol-binding protein which belongs to the START protein family. Remarkably, STARD3 modulates the cellular organization by creating membrane contact sites between the endoplasmic reticulum (ER) and endosomes. The link between ER-endosome contact sites and cholesterol transport was not understood. In this work, we showed that STARD3 and its ER–resident partner, VAMP–associated protein (VAP), assemble into a machine that allows a highly efficient transport of cholesterol within ER–endosome contacts. This cholesterol transport provides building blocks for endosome inner membranes formation, and is probably involved in endosome dynamics. Furthermore, we studied STARD3 function in Niemann Pick type C disease, a condition characterized by an impairment of endosomal cholesterol export.
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https://tel.archives-ouvertes.fr/tel-02003382
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Submitted on : Friday, February 1, 2019 - 1:34:57 PM
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WILHELM_Lea_2017_ED414.pdf
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  • HAL Id : tel-02003382, version 2

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Léa Wilhelm. Etude du rôle de STARD3 dans le transport du cholestérol. Biochimie, Biologie Moléculaire. Université de Strasbourg, 2017. Français. ⟨NNT : 2017STRAJ048⟩. ⟨tel-02003382v2⟩

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