Skip to Main content Skip to Navigation
Theses

Aspects fonctionnel et évolutif de l'immunité mémoire chez les invertébrés : l'escargot vecteur de la Bilharziose intestinale Biomphalaria glabrata comme nouvel organisme modèle ?

Abstract : Invertebrates focus in 2017 among the major economical and societal issuesacross Earth. Some members are vectors of important infectious pandemic as malaria(Anopheles sp), Zika, Chinkungunya, Yellow fever, etc (Aedes sp), Chagas (Triatoma sp) andtrematodes (Biomphalaria sp, Bulinus sp). Comprehension of immune system of thesevectors has to help scientist to decrease transmission on endemic area. Biomphalariaexposed first failure to be reinfected following first infection as soon as 1998. In my thesiswe explore this immune priming (innate immune memory) and describe an immune shiftfrom cellular to humoral immune response both in phenotype and transcriptomic response.A specificity is handle by specific immune receptor and effector repertoire to distinguish upto different developmental stage of same parasite species. This interaction is alsodependent of mRNAs and Biomphalysin, a ß-PFT coming from bacterial kingdom. Finally,this resistance seems to look alike the trained immune memory of innate cells in vertebrates.
Document type :
Theses
Complete list of metadata

Cited literature [231 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-01968025
Contributor : Abes Star :  Contact
Submitted on : Wednesday, January 2, 2019 - 1:09:43 AM
Last modification on : Wednesday, November 3, 2021 - 7:39:51 AM
Long-term archiving on: : Wednesday, April 3, 2019 - 12:53:40 PM

File

These_PINAUD_Silvain_2017a.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-01968025, version 1

Collections

Citation

Silvain Pinaud. Aspects fonctionnel et évolutif de l'immunité mémoire chez les invertébrés : l'escargot vecteur de la Bilharziose intestinale Biomphalaria glabrata comme nouvel organisme modèle ?. Sciences agricoles. Université de Perpignan, 2017. Français. ⟨NNT : 2017PERP0037⟩. ⟨tel-01968025⟩

Share

Metrics

Record views

380

Files downloads

2147