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Conception d'un patch transdermique intelligent pour le monitoring et l'aide à la prise de médicament

Yassine Talbi 1
1 LAAS-S4M - Équipe Instrumentation embarquée et systèmes de surveillance intelligents
LAAS - Laboratoire d'analyse et d'architecture des systèmes
Abstract : Personalized monitoring is an emerging ambition for health technologies responding the needs of patients and healthcare professionals. In this regard, the purpose of this work is to propose a e-health care device offering active control and permanent actuating link able to control the amount of drug delivered. A first part presents our motivations related to the problems of the aging of the population, recalls the current approaches for the monitoring of the elderly and describes the need in the systems of actuations in particular for the aid to the taking of drugs. From these needs, a state of the art is proposed on the techniques for controlling the delivery of drugs. Experiments are carried out to demonstrate the efficiency of diffusion techniques controlling and improving the quantity delivered. The control of the administered dose is correlated to the integrated actuator via a control command. We present a modeling and a numerical simulation of the transdermal diffusion related to the results obtained during experiments on a Franz cell, and the transposition of the model on a planar structure. Different scenarios of electrical stimulations and shape factors have been conducted to obtain optimal administration profile. Finally, the last part is devoted to technological locks and to the design of the intelligent system which adapt the dose administered according to the needs of the patient. A prototype is made, integrating actuation functions, and data recovery from integrated sensors.
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Yassine Talbi. Conception d'un patch transdermique intelligent pour le monitoring et l'aide à la prise de médicament. Micro et nanotechnologies/Microélectronique. INSA de Toulouse, 2018. Français. ⟨NNT : 2018ISAT0005⟩. ⟨tel-01829981v2⟩

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