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Deciphering intrinsic and extrinsic machinery underlying collective glia migration using Drosophila as a model organism

Abstract : The remarkable ability of neurons and glia to undergo long distance and collective migration ensures the final architecture and function of the brain. This is an extremely dynamic process that not only depends on cell interactions, but also on the presence of specific transcription factors in the migrating cells. Adhesion molecules such as classic cadherins and chemoattractants/repellants are known to regulate directional migration, however, how are these pathways regulated is largely unknown. While the role of these molecules controlling cell interactions has been extensively investigated, the signaling cascades that trigger chemotropism are not understood. During the course of my PhD I have analyzed the role of an adhesion molecule and the impact of a chemoattractant receptor regulated by an early transcription factor in the process. The glial chain in a developing Drosophila wing provides an excellent tool to study the molecular pathway underlying collective migration.
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Submitted on : Monday, June 18, 2018 - 9:43:08 AM
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  • HAL Id : tel-01817016, version 2

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Tripti Gupta-Bosch. Deciphering intrinsic and extrinsic machinery underlying collective glia migration using Drosophila as a model organism. Neurobiology. Université de Strasbourg, 2016. English. ⟨NNT : 2016STRAJ009⟩. ⟨tel-01817016v2⟩

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