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Theses

Diffuse reflectance endoscopic imaging for bladder early-stage cancer and pre-cancer diagnosis: instrumentation, modelling and experimental validation

Abstract : The present thesis aimed to evaluate the performance of non-invasive optical method for bladder pre- and early- cancer detection by means of diffuse-reflected laser light analysis. The analysis of light distribution at the surface of multi-layered bladder phantoms with different scattering and absorption properties showed that the changes in the optical properties lead to increase or decrease of the diffuse-reflected light spot area, detectable by a video camera. It was also determined, that the presented method is capable of detection of the photosensitizer accumulation, and can be applied for both (diffuse-reflected laser and fluorescence) studies simultaneously. The calculations for spherical and "coated"-spherical tissue scatterers, based on the electromagnetic wave theory, allowed for obtaining optical parameters of three-layered biological phantoms and of bladder tissues at different states. These parameters served as inputs for Monte Carlo simulations, which provided us with matrices of diffuse-reflected light distributions. The study showed that the measurements of non-polarized back-scattered laser light can provide useful information on the tissue state.
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https://tel.archives-ouvertes.fr/tel-01749304
Contributor : Walter Blondel <>
Submitted on : Friday, October 19, 2012 - 3:12:30 PM
Last modification on : Friday, October 23, 2020 - 8:38:04 AM
Long-term archiving on: : Sunday, January 20, 2013 - 3:41:02 AM

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  • HAL Id : tel-01749304, version 2

Citation

Nina Kalyagina. Diffuse reflectance endoscopic imaging for bladder early-stage cancer and pre-cancer diagnosis: instrumentation, modelling and experimental validation. Bioengineering. Université de Lorraine; Prokhorov General Physics Institute, 2012. English. ⟨NNT : 2012LORR0099⟩. ⟨tel-01749304v2⟩

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