Skip to Main content Skip to Navigation
Theses

Troubles visuels chroniques, nystagmus pendulaire et oscillopsie dans la sclérose en plaques

Abstract : Neuro-ophthalmic manifestations observed in multiple sclerosis are well-known. However, the chronic feature of visual dysfunctions is not always precisely determinated. These imprecision impede the development of specific therapeutic approach. In a first part, the chronic characteristics of visual dysfunctions were assessed. The percentage of chronic visual complaints in multiple sclerosis patients was quantified and then the intensity of chronic visual deficits was measured, their pathophysiologic origins determined and finally their impact on quality of life was taken into account. Visual pathways were impaired in 68% of patients. Ocular motor disorders were frequently observed (89%) including pendular nystagmus (28%), accounted for visual discomfort. In a second part, we focused on pendular nystagmus and its functional consequence, oscillopsia, to propose a specific treatment. First of all, the mechanisms of this nystagmus are not yet well defined. Therefore, we developed some hypothesis from the observation of two patients with monocular nystagmus and demonstrated in a second part that the pendular nystagmus in multiple sclerosis is distinct from the pendular nystagmus of oculopalatal tremor. Finally, we proposed a method evaluating oscillopsia (motion detection by contrast stimuli moving synchronically with gaze) that was tested before and after an optokinetic stimulation protocol aimed to reduce this symptom
Document type :
Theses
Complete list of metadatas

Cited literature [226 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-00666004
Contributor : Abes Star :  Contact
Submitted on : Wednesday, January 8, 2014 - 10:01:31 AM
Last modification on : Wednesday, November 20, 2019 - 3:16:22 AM
Long-term archiving on: : Tuesday, April 8, 2014 - 10:26:09 PM

File

TH2011_Jasse_Laurence_V_Abrege...
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-00666004, version 2

Citation

Laurence Jasse. Troubles visuels chroniques, nystagmus pendulaire et oscillopsie dans la sclérose en plaques. Médecine humaine et pathologie. Université Claude Bernard - Lyon I, 2011. Français. ⟨NNT : 2011LYO10073⟩. ⟨tel-00666004v2⟩

Share

Metrics

Record views

1281

Files downloads

2786