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Modulographie vasculaire : Application à l'identification in-vivo du module de Young local des plaques d'athérosclérose

Simon Le Floc'H 1
1 DynaCell
TIMC-IMAG - Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525
Abstract : This thesis has the ambition to develop tools for assisting diagnosis of patients with cardiovascular disease. It is part of a research program which focuses on developing new methodologies for in-vivo characterization of coronary atherosclerotic plaques and the prediction of their rupture. This work deals with inverse problems in continuum mechanics, namely the local estimation of the mechanical properties of a medium from full-field measurements. In this context, we propose to use criteria based on continuum mechanics for the detection of heterogeneities allowing a pre-conditioning method for the algorithms estimating the distribution of Young modulus. The use of such criteria is performed by using a parametric model driven by an iterative segmentation of the domain. The tool developed in this thesis, the iMOD (for imaging modulography) was firstly validated using simulated strains. In a second step, we used polymer models replicating of the arterial walls which contained heterogeneities. This experimental phase has allowed us to estimate the accuracy of the identification method of Young modulus by comparison with the Young's modulus resulting of micropipette aspiration experiment. Finally, we estimated the local distribution of the Young modulus corresponding to four human atherosclerotic plaques using clinical data acquired in-vivo. The iMOD is very promising to provide information about plaque morphology for clinical diagnosis. In addition, this tool could help to a better understanding of the development of atherosclerotic plaque, as it gives information about the tissue stiffness which is directly related with its biological composition.
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https://tel.archives-ouvertes.fr/tel-00424972
Contributor : Simon Le Floc'H <>
Submitted on : Monday, December 14, 2009 - 12:06:56 PM
Last modification on : Tuesday, June 1, 2021 - 3:44:12 PM
Long-term archiving on: : Thursday, September 23, 2010 - 11:25:53 AM

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  • HAL Id : tel-00424972, version 2

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Simon Le Floc'H. Modulographie vasculaire : Application à l'identification in-vivo du module de Young local des plaques d'athérosclérose. Mécanique [physics.med-ph]. Université Joseph-Fourier - Grenoble I, 2009. Français. ⟨tel-00424972v2⟩

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