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LE STRESS OXYDANT INDUIT PAR VOIE METABOLIQUE (REGIMES ALIMENTAIRES) OU PAR VOIE GAZEUSE (HYPEROXIE) ET EFFET DE LA GLISODIN®

Abstract : MITOCHONDRIA, THROUGH ITS RESPIRATORY CHAIN, IS THE MAIN SOURCE OF REACTIVE OXYGEN SPECIES (ROS). TWO ESSENTIAL PARAMETERS CAN MODULATE THAT PRODUCTION: THE NATURE OF REDUCED EQUIVALENTS (NADH, H+ AND FADH2) AND THE SUPPLY IN OXYGEN. IN THE PRESENT STUDY, WE EXAMINED THE EFFECTS OF DIETS (MODIFYING THE PROPORTION BETWEEN NADH,H+ AND FADH2) AND OF HYPEROXIA (MODIFYING THE SUPPLY IN O2) ON THE PRODUCTION OF H2O2 BY SKELETAL MUSCLE AND/OR LIVER RAT MITOCHONDRIA. IT APPEARS THAT FAT INTAKE REVERSES THE BENEFICIAL EFFECTS OF CALORIC RESTRICTION ON ROS PRODUCTION. HIGH FRUCTOSE DIET INCREASES OF H2O2 RELEASED BY MITOCHONDRIA, THAT CAN BE PREVENTED BY GLISODIN® A VEGETABLE SUPEROXIDE DISMUTASE (SOD) SUPPLEMENT. HYPEROXIC PRECONDITIONING (4 DAYS AT 50% OF O2 FOLLOWED BY 5 DAYS AT 80% OF O2) WOULD REDUCE THE ROS PRODUCTION BY ENHANCING CYTOCHROME C OXYDASE (COX) ACTIVITY.
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https://tel.archives-ouvertes.fr/tel-00120861
Contributor : Blandine Garait <>
Submitted on : Monday, December 18, 2006 - 5:51:47 PM
Last modification on : Friday, November 6, 2020 - 4:12:06 AM
Long-term archiving on: : Monday, September 20, 2010 - 6:06:55 PM

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  • HAL Id : tel-00120861, version 2

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Blandine Garait. LE STRESS OXYDANT INDUIT PAR VOIE METABOLIQUE (REGIMES ALIMENTAIRES) OU PAR VOIE GAZEUSE (HYPEROXIE) ET EFFET DE LA GLISODIN®. Biologie cellulaire. Université Joseph-Fourier - Grenoble I, 2006. Français. ⟨tel-00120861v2⟩

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