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PERTURBATION DE LA DYNAMIQUE DE L'HETEROCHROMATINE PAR
DES LIGANDS SYNTHETIQUES DU PETIT SILLON DE L'ADN

Abstract : The satellite III sequences (SATIII) composing the pericentric regions of the X
chromosome are the only alphoïd sequences found in Drosophila melanogaster.
They are similar to those found near the centromeres of mammalian cells. Their
structural characteristics, based on their biased, A•T rich, nucleotidic composition,
make them good targets for different types of artificial and natural molecules. We
propose to use the SAT III sequences as a model to study the histone code, the
function of pericentric regions and as a tool to evaluate the pharmacological
potential of diamidines. Our work with minor groove binding agents, allowed us to
shed light on the functional role of topoisomerase II, a major target in anticancer and
antiparasitic therapies, in the heterochromatin assembly process and in the antiproliferative mode of action diamidines
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https://tel.archives-ouvertes.fr/tel-00107105
Contributor : Chantal Michel <>
Submitted on : Friday, March 23, 2007 - 11:04:52 AM
Last modification on : Wednesday, January 20, 2021 - 3:26:04 PM
Long-term archiving on: : Tuesday, September 21, 2010 - 12:38:57 PM

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  • HAL Id : tel-00107105, version 2

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Guillaume Susbielle. PERTURBATION DE LA DYNAMIQUE DE L'HETEROCHROMATINE PAR
DES LIGANDS SYNTHETIQUES DU PETIT SILLON DE L'ADN. Biochimie [q-bio.BM]. Université Paul Sabatier - Toulouse III, 2006. Français. ⟨tel-00107105v2⟩

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