Pipecolate and taurine, rat urinary biomarkers for lysine and threonine deficiency

Dalila Azzout-Marniche (1) , Joanna Moro (1) , Gaëtan Roisné-Hamelin (1) , Nadezda Khodorova (1) , Douglas N Rutledge , Jean-Charles Martin , Pierre Barbillon , Daniel Tomé (1) , Claire Gaudichon (1) , Catherine Tardivel , Delphine Jouan-Rimbaud Bouveresse (1, 2, 3)

1 PNCA (UMR 0914) - Physiologie de la Nutrition et du Comportement Alimentaire
2 IAQA - Ingénierie Analytique pour la Qualité des Aliments
3 GENIAL - Ingénierie, Procédés, Aliments

Pipecolate and taurine, rat urinary biomarkers for lysine and threonine deficiency Materiel and Methods Chemometric Analysis LC-MS Discriminant Component Mass Spectra 24h urine Portal and vena cava plasma 15 % 170% Lysine deficiency Threonine deficiency Biomarker Detection 3 weeks The quality of dietary protein sources became a particularly sensitive issue in the current debates on a rebalancing between animal and plant food sources. The ability of a protein to meet the nutritional requirements of essential amino acids (EAA) is the basis for assessing the quality of protein. The objective of this study was to develop metabolomic approaches to identify specific biomarkers for an EAA deficiency, such as lysine and threonine.

Keywords: Nutrition; Nutrition

Domains: Food and Nutrition

Dalila Azzout-Marniche, Joanna Moro, Gaëtan Roisné-Hamelin, Nadezda Khodorova, Douglas N Rutledge, et al.. Pipecolate and taurine, rat urinary biomarkers for lysine and threonine deficiency. International Symposium on « Dietary Protein for Human Health », Sep 2023, Utrecht, Netherlands. . ⟨hal-04311408⟩