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Journal articles
Mitochondrial reactive oxygen species regulate the induction of CD8+ T cells by plasmacytoid dendritic cells
Abstract : Cross-presentation allows exogenous antigen presentation in association with major histocompatibility complex class I molecules, a process crucial for the priming of CD8+ T-cell responses against viruses and tumors. By contrast to conventional dendritic cells (cDC), which cross-present antigens in the steady state, plasmacytoid dendritic cells (pDC) acquire this ability only after stimulation by Toll-like receptor (TLR) ligands. The intracellular pathways accounting for this functional difference are still unknown. Here we show that the induction of cross-presentation by pDCs is regulated by mitochondria through a reactive oxygen species (ROS)-dependent mechanism, involving pH alkalization and antigen protection. The reduction of mitochondrial ROS production dramatically decreases the cross-presentation capacity of pDCs, leading to a strong reduction of their capacity to trigger CD8+ T-cell responses. Our results demonstrate the importance of mitochondrial metabolism in pDC biology, particularly for the induction of adaptive immune responses.
Cited literature [48 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-01899394
Contributor : Laurence Langlais <>
Submitted on : Friday, October 19, 2018 - 2:26:03 PM
Last modification on : Monday, December 14, 2020 - 5:26:04 PM
Long-term archiving on: : Sunday, January 20, 2019 - 3:06:39 PM
Contributor : Laurence Langlais <>
Submitted on : Friday, October 19, 2018 - 2:26:03 PM
Last modification on : Monday, December 14, 2020 - 5:26:04 PM
Long-term archiving on: : Sunday, January 20, 2019 - 3:06:39 PM
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Distributed under a Creative Commons Attribution 4.0 International License