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Synthèse, caractérisations structurales par spectroscopie et mise en forme d'hydroxyapatites dopées au cuivre ou au fer

Abstract : Hydroxyapatite (HA), with formula Ca10(PO4)6(OH)2, is one of the most used material in bone reconstruction. The improvement of its biological properties, in particular by doping with trace elements present in the body, is the subject of recent studies. Therefore, this work deals with the elaboration, structural characterizations from spectroscopy and shaping of copper- or iron-doped hydroxyapatite. Two synthesis routes have been considered: syntheses by aqueous co-precipitation led to the elaboration of pure HA phases doped with copper(II) or iron(III) stable at low temperature (≤ 600°C) while high temperature solid-state reactions led to the elaboration of pure HA phases doped with copper(I), iron(II) or iron(III) stable above 1100°C. These phases have been characterized by XRD and various spectroscopic techniques: FTIR, NMR, UV-vis-NIR, XPS, EPR, XANES-EXAFS and Mössbauer in order to evaluate the influence of the incorporation of the different transition elements into the apatitic structure and to determine the location of the doping element, its degree of oxidation, its coordination, as well as its local environment. The influence of copper and iron on the sinterability and densification of ceramics obtained by solid-state reaction and on the granular growth has been then established. In the case of copper-doped HA ceramics, the biocompatibility of the materials has been verified over a 5-day culture time using MC3T3-E1 cell line and the presence of copper does not seem to affect the cell differentiation onto the ceramic surface (up to 5.3 wt%). Finally, pre-sintered 2D films of the HA phase containing 0.8 wt% of copper have been shaped by selective laser sintering.
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Submitted on : Friday, September 23, 2022 - 1:02:37 AM
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Tiphaine Bazin. Synthèse, caractérisations structurales par spectroscopie et mise en forme d'hydroxyapatites dopées au cuivre ou au fer. Matériaux. Université de Bordeaux, 2020. Français. ⟨NNT : 2020BORD0118⟩. ⟨tel-03784315⟩

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