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Preparation of etoposide nanocrystals suspension by co-precipitation for enhanced targeting and sustained release in cancer therapy

Abstract : Solubility enhancement of poorly water-soluble drugs is a major challenge in the pharmaceutical field since 70% of the drugs exhibit low solubility. Nanocrystal (NC) formulations is one of the recent techniques developed to improve dissolution rate, solubility and, therefore bioavailability of active ingredients. Moreover, nanocrystal formulations can be administered through several routes and provide a better performance in term of safety, targeting efficiency, pharmacodynamics and pharmacokinetics. Etoposide is derived from the podophyllotoxin. It is an inhibitor of the topo-isomerase II which inhibits the mitosis of tumoral cells. Etoposide is active in pulmonary, testis and ovarian cancer.
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  • HAL Id : tel-03626758, version 1

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Brice Martin. Preparation of etoposide nanocrystals suspension by co-precipitation for enhanced targeting and sustained release in cancer therapy. Pharmacology. Université Paris Cité, 2019. English. ⟨NNT : 2019UNIP5044⟩. ⟨tel-03626758⟩

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