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Ecotoxicité directe et transgénérationnelle du glyphosate seul ou associé à des co-formulants sur la santé de la truite arc-en-ciel (Oncorhynchus mykiss) : reproduction, immunité et défenses antioxydantes

Abstract : Glyphosate is the most used herbicidal active substance (AS) worldwide and is ubiquitous in surface waters. Evaluation of the ecotoxicity of this AS and its commercial formulations called "Glyphosatebased herbicides" (GBHs) is complex and controversial.Glyphosate and its co-formulants could be toxic for fish and little is known about their interactions.The vertical transmission of this toxicity among generations is also poorly studied. We investigated the direct and generational toxicity of environmentally relevant concentrations of glyphosate on several generations of rainbow trout chronically exposed to the AS or two GBHs. Fish health status was evaluated by measuring biometric, compartmental and reproductive parameters. Immunity was considered during experimental viral infections. Energetic metabolism and antioxidant system were followed up using different biochemical markers. Direct exposure of F0 generation to contaminants did not impact fish physiology or reproduction. F1 and F2 offsprings showed a disturbed embryo-larval development associated to direct, inter and transgenerational exposures; with a suggested effect of a re-exposure to parental compounds.Even if most of the changes observed on early stages were not detected on juvenile trout, their viral susceptibility was significantly affected. Comparisons between glyphosate and GHBs seem to demonstrate a role of the co-formulants in the modulation of the toxicity of the AS. However, further studies will be required to better understand the complex mechanism of glyphosate toxicity transmission and its modulation by co-formulants.
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https://tel.archives-ouvertes.fr/tel-03614998
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Submitted on : Monday, March 21, 2022 - 11:31:30 AM
Last modification on : Thursday, April 28, 2022 - 3:48:02 PM

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Jessy Le Du-Carrée. Ecotoxicité directe et transgénérationnelle du glyphosate seul ou associé à des co-formulants sur la santé de la truite arc-en-ciel (Oncorhynchus mykiss) : reproduction, immunité et défenses antioxydantes. Biologie animale. Université de Bretagne occidentale - Brest, 2021. Français. ⟨NNT : 2021BRES0016⟩. ⟨tel-03614998⟩

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