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Acetylated lignin nanoparticles as a new photosensitizer's vehicle for Photodynamic antimicrobial chemotherapy (PACT)

Abstract : Antibacterial resistance is a threat to the developments of modern medicine, representing an economic, and social burden in years to come. This crisis is enhanced by a belittled pipeline of novel antibacterial drugs, due to the high research costs and low profitability. Furthermore, the development of new, specific molecules is not guarantee that antibacterial resistance will not arise against any new molecule, and then there is a growing tendency to look for antibacterial alternatives with unspecific molecular targets. In this aspect, Photodynamic Antimicrobial ChemoTherapy achieves bacterial disinfection through the use of a photosensitizing molecule which is only active upon light irradiation, adding another level of control to the process. In this work, we present a biopolymeric delivery system for photosensitizing molecules, as acetylated lignin nanoparticles. The preparation, physical characterization and photophysical characterization are discussed along this project, exploring the effects of the encapsulation towards the photosensitizer. Finally, these nanoparticles were tested against bacteria, finding that they were able to efficiently eradicate them only upon light irradiation, demonstrating low dark toxicity, and stability over time and light exposure. Then, this formulation for photosensitizing molecules has proven to be an efficient antibacterial formulation, fulfilling its purpose, while tackling antibacterial disinfection and valorizing a highly abundant biopolymer.
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https://tel.archives-ouvertes.fr/tel-03565910
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Submitted on : Friday, February 11, 2022 - 11:48:09 AM
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  • HAL Id : tel-03565910, version 1

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Nidia Maldonado Carmona. Acetylated lignin nanoparticles as a new photosensitizer's vehicle for Photodynamic antimicrobial chemotherapy (PACT). Organic chemistry. Université de Limoges; Universidade de Coimbra, 2021. English. ⟨NNT : 2021LIMO0106⟩. ⟨tel-03565910⟩

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