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Modélisation paramétrique de l'hyperémie fonctionnelle en IRMf ASL comme un mélange de sources

Abstract : Neural activity leads to an increase in cerebral blood volume and flow by vasodilatation of the small cerebral blood vessels. This is the phenomenon of functional hyperaemia, which is induced by neurovascular coupling. Functional hyperaemia is directly measurable with the ASL fMRI imaging technique. Impaired functional hyperemia has been observed in some neurodegenerative diseases such as CADASIL arteriopathy. The aim of this thesis is to propose a model of the functional hyperaemia measured in an ASL fMRI voxel and a suitable method to its identification. We propose the Fast-Slow parametric model. It models a flow response to neuronal stimulation as being induced by two temporally and spatially distinct "fast" and "slow" vasodilatory mechanisms. This model depends on dynamic parameters characterising the shape of the response for each mechanism per brain region and on parameters characterising the contribution of the two mechanisms per voxel. In a first step, we developed and validated several estimation strategies adapted to the problem of identifying the parametric model from simulated relative flow data. In a second step, based on the best strategy, we validated the use of the model on real ASL fMRI data measured in CADASIL patients and Control subjects in order to differentiate the data of these two groups. The Fast-Slow model also allows the construction of maps of spatial distributions of voxel parameters. This thesis shows that our model allows the extraction of spatial and temporal information from ASL fMRI data in order to improve the understanding of neurovascular coupling.
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Submitted on : Monday, February 7, 2022 - 6:15:10 PM
Last modification on : Wednesday, April 27, 2022 - 4:54:52 AM
Long-term archiving on: : Sunday, May 8, 2022 - 7:25:37 PM


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  • HAL Id : tel-03560852, version 1


Diane Mornas. Modélisation paramétrique de l'hyperémie fonctionnelle en IRMf ASL comme un mélange de sources. Ingénierie biomédicale. École centrale de Nantes, 2021. Français. ⟨NNT : 2021ECDN0027⟩. ⟨tel-03560852⟩



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