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Etude numérique des paramètres de contrôle du couplage entre l'hémodynamique artérielle et le stent à élution médicamenteuse

Abstract : Cardiovascular disease has been strongly threatening people's life leading to heart attacks, stokes and even deaths especially in western countries. Confronting the generation of stenosis blocking the blood flow, stent implantation has been a significant progress currently for the treatments. However, the complications following stent implantation require the optimization of stent necessarily. Therefore, in the present study, the computational fluid dynamics is carried out aiming to better acknowledge the physical and mechanical characteristics of blood flow as well as mass transfer from drug-eluting stent (DES) in order to improve the stent performance. Considering the complex physics related in artery, the modeling characteristics of blood flow in coronary artery have been discussed and determined in numerical and mathematical views. Modeling validation has been carried out with the preliminary studies regarding blood flow in stenotic artery coupling the main arterial geometrical characteristics: bifurcation and tortuosity separately. Both hemodynamic and practical diagnostic analysis have been conducted to evaluate the stenosis development, potential stenosis sites and give guidance to practice treatment. With the purpose of stent optimization, the following research were carried out focusing on the blood flow in stented coronary artery aiming to investigate the interaction between the blood flow and stent performance with different geometrical design factors. Furthermore, considering the drug transfer from DES, the physical coupling between flow and mass transfer has been established in order to better acknowledge the drug transport process numerically and experimentally. The results reveal that less intrusion of stent in flow domain is beneficial to reduce flow disturbance and prolong drug retain time in tissue. A good comparison of drug release from polymer has been achieved between numerical and experimental results.
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https://pastel.archives-ouvertes.fr/tel-03407901
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Submitted on : Thursday, October 28, 2021 - 5:06:14 PM
Last modification on : Saturday, October 30, 2021 - 3:22:12 AM

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  • HAL Id : tel-03407901, version 1

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Jianfei Song. Etude numérique des paramètres de contrôle du couplage entre l'hémodynamique artérielle et le stent à élution médicamenteuse. Biomécanique [physics.med-ph]. HESAM Université, 2021. Français. ⟨NNT : 2021HESAE010⟩. ⟨tel-03407901⟩

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