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Towards new means of performing multi T1-weighted contrast imaging and T1 mapping with the FLAWS magnetic resonance sequence

Abstract : The FLAWS brain magnetic resonance imaging sequence provides two coregistered T1-weighted contrasts characterized by a suppression of the white matter and cerebrospinal fluid signals, respectively. The computation of the minimum between these two images provides a GM-specific contrast. The contrasts provided by the FLAWS sequence are of interest for deep brain stimulation surgery planning applications and for brain lesion detection. When this thesis started, the FLAWS sequence was only available for 3T imaging. The work presented in this thesis proposes an optimization method based on the maximization of a profit function under constraints and prior information about the brain tissues T1 relaxation times to determine FLAWS sequence parameters. This method was used to propose sets of FLAWS sequence parameters for 1.5T and 7T imaging. A new combination of the FLAWS signals is proposed to generate T1-weighted images characterized by a reduced sentisitivity to the B1 magnetic field inhomogeneities. In addition, this new combination of FLAWS signals was used to generate T1 maps of the brain tissues. We show that the FLAWS T1 maps are characterized by a reduced sensitivity to the transmitted magnetic field inhomogeneities. The methods presented in this thesis were validated by performing experiments on a phantom at 3T and on healthy volunteers at 1.5T and 7T.
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Submitted on : Thursday, June 24, 2021 - 4:38:09 PM
Last modification on : Friday, June 25, 2021 - 3:36:56 AM

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  • HAL Id : tel-03270328, version 1

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Jérémy Beaumont. Towards new means of performing multi T1-weighted contrast imaging and T1 mapping with the FLAWS magnetic resonance sequence. Signal and Image processing. Université Rennes 1; Commonwealth scientific and industrial research organization (Australie), 2020. English. ⟨NNT : 2020REN1S106⟩. ⟨tel-03270328⟩

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