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Bases cellulaires et moléculaires de la régénération chez la méduse Clytia hemisphaerica

Abstract : The hydrozoan jellyfish Clytia hemisphaerica displays very efficient wound repair mechanisms after different types of injury. During my PhD, I investigated in the medusa the cellular and molecular processes involved in the regeneration of the feeding organ, called ‘manubrium’, ensuring the function of the mouth and stomach. I could define three successive phases during the wound response: wound healing, remodeling of the umbrella allowing the rapid recovery of the circular medusae shape, followed by the regeneration of some of the missing organs. Manubrium regeneration relies on local proliferation as well as cell migration from the gonads. Structural elements, especially the muscle fibers, play a key role in the repatterning process of the umbrella and the site of manubrium regeneration. I also generated transcriptomic data covering the early steps of regeneration. These data allowed the identification of markers of different cell types of the manubrium and documentation of their sequential reappearance during regeneration. They also revealed dynamic expression profiles for Wnt/β-catenin pathway components in the regenerating manubrium, strongly suggesting important roles for this pathway during regeneration. This work confirmed the potential of Clytia medusae as an experimental model for studying regeneration, allowing conserved cellular and molecular mechanisms to be uncovered, and our knowledge about the evolution of regeneration mechanisms in metazoans to be expanded.
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  • HAL Id : tel-03139846, version 1

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Sophie Peron. Bases cellulaires et moléculaires de la régénération chez la méduse Clytia hemisphaerica. Biologie cellulaire. Sorbonne Université, 2019. Français. ⟨NNT : 2019SORUS325⟩. ⟨tel-03139846⟩

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