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Etude de la nano-organisation dynamique de la protéine Gag du VIH-1 à la membrane plasmique des Lymphocytes T CD4+ au cours de l'assemblage viral

Abstract : HIV-1 presents a threat for the public health because either no vaccine or no effective antiviral therapy still exists targeting the late stages of their replication. During my thesis, I chose to be interested in the mechanisms of assembly of this burgeoning retrovirus of the plasmic membrane of the infected cells. In a cellular context, I would study the late stages of the replication of the HIV 1, in particular, in the regulation of the dynamics membranaire modulated during the assembly of the HIV-1 thanks to state-of-the-art techniques in microscopy of high-resolution fluorescence. So, we shall try to understand the molecular mechanisms and the cellular, protein or lipid factors, involved in the assembly and the budding of the HIV-1 in hosts cells, the lymphocyte T CD4 +
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Charlotte Floderer. Etude de la nano-organisation dynamique de la protéine Gag du VIH-1 à la membrane plasmique des Lymphocytes T CD4+ au cours de l'assemblage viral. Médecine humaine et pathologie. Université Montpellier, 2016. Français. ⟨NNT : 2016MONTT075⟩. ⟨tel-02987639⟩

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