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Analyses génomiques et épigénomiques pour le développement d’une médecine de précision dans le myélome multiple

Abstract : Multiple myeloma (MM) is the second most common hematological malignancy after lymphoma. Recent advances in treatment have led to an overall survival of intensively-treated patients of 6-7 years. However, patients invariably relapse after multiple lines of treatment, with shortened intervals between relapses, and finally become resistant to all treatments, resulting in loss of clinical control over the disease in association with drug resistance. Treatment improvements will come from a better comprehension of tumorigenesis and detailed molecular analyses to develop individualized therapies taking into account the molecular heterogeneity and subclonal evolution. In this purpose, we analyzed the exome, transcriptome and epigenome of primary MM cells from patients and human MM cell lines. Our results have highlighted new mechanisms involved in the pathophysiology of MM as well as potential new therapeutic targets, prognostic signatures and theranostic biomarkers. The data and results of our studies represent an important resource to understand the mechanisms of tumor progression and drug resistance and develop new ways to diagnose and treat patients.
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Veronika Vikova. Analyses génomiques et épigénomiques pour le développement d’une médecine de précision dans le myélome multiple. Cancer. Université Montpellier, 2019. Français. ⟨NNT : 2019MONTT031⟩. ⟨tel-02985577⟩

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