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Diabète de type 1 du modèle ... à la boucle fermée

Abstract : For people living with type 1 diabetes, today’s treatment consists of a number of daily insulin injections in order to have a limited glycemic excursion. Poorly controlled glycemia leads to long term complications. In patient’s everyday life, functional insulin therapy helps patients to adjust insulin doses. The artificial pancreas could significantly improve glycemia equilibrium by means of an automated insulin infusion using continuous glucose monitoring. The first contribution of this thesis is a new model of the metabolism for type 1 diabetic. The interpretation of this model allows to compute the tools for the functional insulin therapy. Thus it becomes possible to advise the patient on how much insulin to inject. The ongoing clinical study will evaluate the impact of the model. The second contribution is a control-law that guaranties both hypoglycemia avoidance and positivity of the injection for the first time. It is inspired from the clinical practice. The theoretical proof makes use of the theory of positively invariant sets. The Hypo-Free Hyper-Minimizer is designed to regulate glycemia in a hybrid closed-loop whereas the Dynamic Bolus Calculator is designed for the fully-automated artificial pancreas. This control-law gathers clinical practice, artificial pancreas hard constraints, and theoretical proof and is being protected through a patent.
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Submitted on : Wednesday, October 28, 2020 - 10:57:12 AM
Last modification on : Wednesday, April 27, 2022 - 3:45:58 AM
Long-term archiving on: : Friday, January 29, 2021 - 6:22:35 PM


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  • HAL Id : tel-02981686, version 1


Nicolas Magdelaine. Diabète de type 1 du modèle ... à la boucle fermée. Automatique / Robotique. École centrale de Nantes, 2017. Français. ⟨NNT : 2017ECDN0034⟩. ⟨tel-02981686⟩



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