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Un nouveau type de substitut vasculaire obtenu par tissage de fils issus de la membrane amniotique humaine

Abstract : In response to the poor performance of synthetic prostheses for small-diameter revascularizations (≤ 6 mm), a great deal of research has focused on the development of biological vascular substitutes. Although promising results have been obtained, the production of these grafts mainly relied on expensive tissue engineering methods. Consequently, our objective was to inexpensively produce a small diameter human biological vascular substitute. Thus, the human amniotic membrane (HAM) and a cell-free assembly method based on weaving were associated. First, to improve our knowledge of this tissue, a detailed study of the mechanical properties demonstrated that the placental HAM is a mechanically strong area that should not be neglected during our yarn production. Then, cutting the HAM allowed the production of yarns that were characterized and assembled by hand weaving to produce vascular substitutes. In vitro, these grafts had mechanical properties (burst pressure, suture retention, transmural permeability) compatible with a clinical use, justifying the translation to arterial implantation in animals.
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Submitted on : Thursday, October 22, 2020 - 2:33:08 PM
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Agathe Gremare. Un nouveau type de substitut vasculaire obtenu par tissage de fils issus de la membrane amniotique humaine. Médecine humaine et pathologie. Université de Bordeaux, 2020. Français. ⟨NNT : 2020BORD0060⟩. ⟨tel-02975171⟩

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