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-. Chu-bichat, A. Bernard, and S. De-gériatrie,

, Ceux-ci altèrent la qualité de vie des patients et de leur entourage, et peuvent conduire à l'institutionnalisation des malades. L'objectif de ce chapitre est de décrire les altérations du sommeil observées dans plusieurs maladies neurodégénératives. Ainsi, nous nous intéresserons aux deux principales démences avec synucléinopathies, à savoir la démence parkinsonienne, et la démence à corps de Lewy, Les patients atteints de maladies neurodégénératives se plaignent très fréquemment de troubles du sommeil

. Hely, La démence Parkinsonienne Il s'agit d'une démence à prédominance sous-corticale qui survient au cours de l'évolution à long terme d'une maladie de Parkinson. Selon les résultats d'une méta-analyse (Aarsland 2005) et d'une cohorte de suivi (Sydney multicenter study, 2008.

, 50% à 15 ans et 80% à 20 ans d'évolution. Le syndrome dyséxecutif, les troubles attentionnels et le déficit mnésique d'allure sous corticale prédominent généralement le tableau cognitif et sont à l'origine d'une perte d'autonomie

. Montplaisir, pour une étude mettant en évidence des quantités équivalentes de sommeil paradoxal chez des patients Alzheimer, dont les scores au MMS étaient compris entre 12 et 26, et des sujets témoins) et se traduit par un allongement de la latence d'apparition, une réduction de la durée moyenne des épisodes (Montplaisir et al., 1995) ainsi qu'une fragmentation de ce stade de sommeil (Onen & Onen, Certains troubles sont, en revanche, spécifiques de la pathologie. Ainsi, l'atteinte du sommeil paradoxal est un élément caractéristique de la maladie d'Alzheimer. Toutefois, cette atteinte surviendrait à un stade relativement avancé de la démence, 1995.

L. Enfin and . Beebe, apnées du sommeil est fréquemment associé à la maladie d'Alzheimer, aggravant potentiellement les déficits cognitifs, a rapporté que parmi les individus présentant un déclin cognitif modéré ou une maladie d'Alzheimer, 2003.

. Spira, En revanche, le temps total de sommeil, estimé par actimétrie, ne différait pas entre les deux groupes. Enfin, Spira et collaborateurs ont montré qu'un sommeil de qualité médiocre ou de durée insuffisante (£ 6 heures) était associé à une augmentation de la charge amyloïde (évaluée en Tomographie par Emission de Positons (TEP) et du radioligand PiB) chez des sujets âgés sains, En revanche, le traitement de cette pathologie par une ventilation en pression positive APOE ?4, 2013.

. Ma-(ju, Cette boucle de rétrocontrôle positif ainsi que les facteurs susceptibles d'influer les liens entre sommeil et maladie d'Alzheimer sont illustrés en Figure 1. Ainsi, le syndrome d'apnées du sommeil, Plusieurs auteurs ont tenté d'expliquer les interactions réciproques entre sommeil, 2013.

, Figure 1 : Modèle des interactions entre qualité de sommeil et dépôts amyloïdes dans la MA

D. Ju, , 2013.

. Morton, Par ailleurs, des travaux menés sur un modèle murin de cette pathologie ont montré que l'architecture de patients présenteraient des troubles respiratoires, Maladie de Huntington Les patients atteints de maladie de Huntington présentent des anomalies du rythme circadien qui n'ont été décrites qu'assez récemment, 2005.

. Onen, En pratique clinique, l'évaluation des troubles du sommeil de ces patients présentant une démence peut être aidée par le SDI (Sleep Disorders Inventory) qui permet de repérer les manifestations nocturnes du patient et la gêne occasionnée sur l, Onen & Onen, 2003.

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URL : https://hal.archives-ouvertes.fr/inserm-00864246

J. H. Roh, Y. Huang, A. W. Bero, T. Kasten, F. R. Stewart et al., Disruption of the sleep-wake cycle and diurnal fluctuation of ?-amyloid in mice with Alzheimer's disease pathology, Science Translational Medicine, vol.4, issue.150, pp.150-122, 2012.

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C. Internationales,

A. L. Branger, NEUROBIOLOGY OF AGING FORMATION UNIVERSITAIRE DIPLOMES 2015-2019 Doctorat de Neuropsychologie et Neurosciences Unité Inserm-EPHE-Unicaen 1077

, Modifications du sommeil liées à l'âge : liens avec la cognition et les biomarqueurs du vieillissement et de la maladie d'Alzheimer en neuroimagerie. Co-supervision : Dr Géraldine RAUCHS (unité Inserm U1077) et Dr Gaël CHETELAT (unité Inserm U1237)

, Qualité du sommeil chez des sujets sains et des patients atteints de Mild Cognitive Impairment: comparaison des méthodes objectives et subjectives de mesure du sommeil, et liens avec le déclin cognitif. Co-supervision : Dr Géraldine RAUCHS (unité Inserm U1077) et Dr Gaël CHETELAT (unité Inserm U1237), vol.2, pp.2013-2015, 2015.

, Liens entre le couplage d'oscillations neuronales lors du sommeil et la cognition. Supervision: Dr Thien Thanh DANG-VU, vol.1, 2014.

, Analyse de questionnaires de sommeil, et exploration des liens entre sommeil et mémoire. Supervision : Dr Géraldine RAUCHS, Unité Inserm-EPHE-Unicaen, vol.1077, 2013.

, FORMATIONS COMPLEMENTAIRES 2017 Lecture et analyse de Polysomnographies -niveau 1, Société Française de Recherche en Médecine du Sommeil

, Formation aux techniques de médiation scientifique -niveau 1, Relais D'Sciences

. Production, . Et, . Articles, . Et, and . De-livre,

C. André, S. Rehel, E. Kuhn, B. Landeau, I. Moulinet et al., Association of sleep-disordered breathing with gray matter volume, perfusion, glucose metabolism and ?-amyloid deposition in older adults

C. André, S. Rehel, E. Kuhn, I. Moulinet, B. Landeau et al., Multimodal neuroimaging correlates of NREM and REM sleep EEG spectral power in aging

C. André, C. Tomadesso, R. De-flores, P. Branger, S. Rehel et al., Brain and cognitive correlates of sleep fragmentation in elderly subjects with and without cognitive deficits, Alzheimers Dement (Amst), vol.11, pp.142-150, 2019.

C. Postel, A. Viard, C. André, F. Guénolé, R. De-flores et al., Hippocampal subfields alterations in adolescents with post-traumatic stress disorder, Hum Brain Mapp, vol.40, issue.4, pp.1244-1252, 2018.
URL : https://hal.archives-ouvertes.fr/inserm-02181572

C. André, F. Onen, and G. Rauchs, Démences et Sommeil, du rapport Sommeil, rythmes et psychiatrie. Editions Dunod, pp.221-233, 2016.

G. Chételat, F. Mézenge, C. Tomadesso, B. Landeau, E. M. Arenaza-urquijo et al., Reduced age-associated brain changes in expert meditators: a multimodal neuroimaging pilot study, Scientific Reports, vol.7, issue.1, p.10160, 2017.

P. Branger, E. Arenaza-urquijo, C. Tomadesso, F. Mézenge, C. André et al., Relationships between sleep quality and brain volume, metabolism, and amyloid deposition in late adulthood, Neurobiol Aging, vol.41, pp.107-114, 2016.
URL : https://hal.archives-ouvertes.fr/inserm-01295793

G. Poisnel, E. Arenaza-urquijo, C. F. Klimecki, O. M. Marchant, N. L. Wirth et al., The age-Well randomized controlled trial of the Medit-Ageing European project: Effect of meditation or foreign language training on brain and mental health in older adults, Alzheimers Dement (N Y), vol.4, pp.714-723, 2018.
URL : https://hal.archives-ouvertes.fr/inserm-02798298

A. Lutz, O. M. Klimecki, F. Collette, G. Poisnel, E. Arenaza-urquijo et al., Ageing Research Group, 2018.

, The Age-Well observational study on expert meditators in the Medit-Ageing European project

, Alzheimers Dement (N Y), vol.4, pp.756-764

. Communications-orales-en and . Congres,

?. Alzheimer-;-andré, C. Rehel, S. Kuhn, E. Landeau, B. et al., Obstructive sleep apnea severity and brain integrity in ageing: a multimodal neuroimaging study, Abstract publié dans Alzheimer's and Dementia, 2019.

C. ?-réunion-francophone-sur-la-maladie-;-andré, C. Tomadesso, R. De-flores, P. Branger, S. Rehel et al., Impact de la fragmentation du sommeil sur les atteintes cérébrales et cognitives chez des sujets âgés sains et des patients présentant des troubles cognitifs légers, Alzheimer et Syndromes Apparentés, 2018.

?. Alzheimer-;-andré, C. Tomadesso, C. Mézenge, F. Branger, P. et al., Age-related NREM-sleep fragmentation: relationships with structural and metabolic brain alterations, s Association International Conference, 2017.

C. André, M. Fossey, C. Malle, P. Branger, F. Mézenge et al., Relationships between sleep fragmentation and Alzheimer's disease biomarkers in healthy older adults: a multimodal neuroimaging study, ? 23 th Congress of the European Sleep Research Society, 2016.

, Withdrawal severity is associated with sleep and cognitive alterations in recently detoxified alcohol use disorder patients. Alice Laniepce, Nicolas Cabé, ? 17 th ESBRA, 2019.

?. Alzheimer, Association of perceived memory decline with multimodal neuroimaging at different stages of Alzheimer's disease, s Association International Conference, 2019.

E. Kuhn, V. De-la-sayette, A. Perrotin, C. Tomadesso, C. André et al.,

, Links between circadian rhythm fragmentation, regular physical activity and amyloid burden in healthy older adults, ? 24 th Congress of the European Sleep Research Society, 2018.

S. Rehel, C. André, A. Ourry, V. Mézenge, F. Vivien et al., Abstract publié dans Journal of Sleep Research

C. Postel, C. André, A. Viard, F. Guénolé, J. Baleyte et al., Hippocampal subfields alterations in teenagers with post-traumatic stress disorder

S. ?-réunion-francophone-sur-la-maladie-;-rehel, C. André, A. Ourry, V. Mézenge, F. Chételat et al., Liens entre fragmentation du cycle veille-sommeil, activité physique quotidienne et charge amyloïde chez des sujets âgés sains, 2018.

C. ?-le-congrès-du-sommeil-;-andré, M. A. Rehel, S. Tomadesso, C. Kuhn, E. Moulinet et al., Impact de la durée de sommeil lent profond sur la charge amyloïde, la structure et la perfusion cérébrale au cours du vieillissement, 2017.

J. ?-le-congrès-du-sommeil-;-mutlu, F. Bertran, C. Harand, F. Doidy, C. André et al., Liens entre les performances mnésiques, la structure cérébrale et les paramètres du sommeil chez des sujets âgés sains, 2017.

?. Alzheimer, ;. Ourry, V. Gonneaud, J. Tomadesso, C. Egret et al., Association of self-perceived physical health with amyloid deposition in cognitively normal older adults, s Association International Conference, 2017.

C. André, C. Tomadesso, F. Mézenge, P. Branger, M. Fossey et al., Relationships between NREM-sleep fragmentation and changes in brain structure, metabolism, amyloid burden and cognitive performance in healthy older adults, ? Human Amyloid Imaging Conference, 2017.

J. O'byrne, O. M. Weiner, C. André, E. Debellemanière, S. Boucetta et al., Budapest, Hongrie). A role for spindle-slow wave synchrony in sleep-dependent declarative memory consolidation, ? 1 st International Conference on Sleep Spindling, 2016.

;. ?-alzheimer, P. Branger, F. Mézenge, C. André, D. Flores et al., Difficulties Falling Asleep Are Associated with Higher A? Burden in Healthy Adults, s Association International Conference, 2015.

P. Branger, F. Mézenge, C. André, D. Flores, R. Egret et al., Difficulties to fall asleep are associated with higher amyloid burden in healthy adults, ? 18 th annual meeting of LARC-Neurosciences network, 2014.

, Enregistrements de sommeil : polysomnographie et actimétrie (recueil, scorage et analyse des données)

?. Neuroimagerie, IRM et TEP (prétraitement, contrôle qualité et analyse avec SPM12), sous-champs hippocampiques (traçage manuel avec Anatomist, et segmentation automatique avec ASHS, contrôle qualité et analyse de données)

, ? Évaluation cognitive et comportementale : cotation et analyse des données

R. Spss, ? Statistiques : analyses avec Statistica

?. Langues, Allemand et Espagnol (notions de base), Français (langue maternelle)

. Activites-d'encadrement-et-d'enseignement,

, ? Encadrement de stages de recherche : o 2 étudiants de niveau Master 1 en neuropsychologie et neurosciences

, ? Formation d'une étudiante en thèse (C. Postel) au traçage manuel des sous-champs hippocampiques

, ? 2016 : deux cours (4h) sur Sommeil, mémoire et maladie d'Alzheimer dispensés dans le cadre du DIU de Médecine du Sommeil appliquée à la Gérontologie (Hôpital Bichat

. Financements-obtenus-?, Bourse de thèse (100 k?) cofinancée 50% Inserm et 50% Région Normandie, avec complément en 4 e année par l'École Pratique des Hautes Études, 2015.

?. Bourses-de-voyage-obtenues-dans-le-cadre-de-congrès, Alzheimer's Association International Conference, 2016.

R. Collectives and . Administratives-?, Représentante élue des doctorants au conseil de l'unité Inserm-EPHE-Unicaen U1077. ? 2016, 2015.

, Représentante « sommeil » lors des conférences grand public de recrutement. o Pré-screening des participants

A. De, . Et, and . Scientifique-?, Participation à la Fête de la Science -Conception et animation du stand de l'Unité Inserm-EPHE-Unicaen 1077, 2015.