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Theses

Les allergènes cutanés réagissant au travers de processus radicalaires : de la molécule au tissu

Abstract : Skin allergy is a major public health problem. It is the most important immunotoxic reaction in humans. Understanding all mechanisms leading to allergic-inflammatory reactions is essential in order to evaluate the sensitization potential of molecules for risk assessment purposes. Hydroperoxides derived from autoxidation of odorant terpenes used in cosmetics cause skin sensitization. The objective was to study the involvement of radical mechanisms in the formation of the antigenic entities of these compounds. An integrated approach of three actions was proposed: - "in chemico" : reactivity studies with amino acids to establish a complete reactivity profile via radical reactions ; - "in situ" : formation and behavior of radical intermediates in a reconstructed human epidermis 3D model ; - "in cellulo" : ability to activate the innate immune system, namely dendritic cells in their natural keratinocyte context
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Fatma Sahli. Les allergènes cutanés réagissant au travers de processus radicalaires : de la molécule au tissu. Chimie organique. Université de Strasbourg, 2019. Français. ⟨NNT : 2019STRAF023⟩. ⟨tel-02968432⟩

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