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Microbiote intestinal chez le porc, facteurs de variation et relations avecles performances des animaux

Abstract : Improving feed efficiency (FE) is a major preoccupation for pig production. The FE is a complex trait dealing with lots of functions in pig. The intestinal microbiota is known to play a key role in host metabolism and health with subsequent impact on its performance. The PhD program aimed at studying the modifications of the intestinal microbiota composition on pigs exposed to several environmental perturbations and to evaluate the relationships between digestive microbiota composition and the host performance. Data from three experimental studies conducted on growing-finishing pigs (60 to 1.200 depending on the study) which were exposed to different perturbations [high fiber diet, diet contaminated by mycotoxin (DON), or exposed to acute or chronic heat stress] have been used. The microbiota analysis was based on fecal samples collected before and after the perturbations. Phenotypes directly or indirectly related to FE were measured to evaluate and to quantifythe relationships between the host performance and its microbiota. A detailed bioinformatic and statistical analysis of the microbial data demonstrated that the environmental perturbations affect the fecal microbiota composition but these effects were generally transient. Depending on the nature of the challenge (standard or high fiber diet, exposition to a chronic or acute heat stress, or DON-contaminated diet), the impact on fecal microbiota composition seemed to differ. In this PhD program, the relative abundance of the OTU does not allow to implement quantitative prediction models of pig performance. Functional
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Submitted on : Wednesday, October 14, 2020 - 9:48:16 AM
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  • HAL Id : tel-02966534, version 1

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Mathilde Le Sciellour Hazon. Microbiote intestinal chez le porc, facteurs de variation et relations avecles performances des animaux. Biologie animale. Agrocampus Ouest, 2019. Français. ⟨NNT : 2019NSARB323⟩. ⟨tel-02966534⟩

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