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Interactions entre CoCrMo et milieu cellulaire : De la corrosion à la tribocorrosion

Abstract : The long-term durability of joint replacements is based on their corrosion resistance and wear behavior. Whatever the materials used, degradation products (metal ions and wear debris) are formed due to the aggressiveness of body fluids and the biomechanics of the joints. Generally, these products are associated with post-operative complications and, as a result, their effects are critical clinical concerns. In this respect, tribocorrosion is a serious consideration in the performance of joint replacements. This work aims to contribute to the improvement of the understanding of the degradation mechanisms of a CoCrMo alloy, used as a joint prosthesis, by understanding the coupling of mechanical loads and cellular activity. This thesis has been structured according to a progressive approach, which begins with the study of the electrochemical behavior of a simulated physiological environment conducive to cell culture (RPMI-1640). Metal alloys and cells were successively added to the study system. The tests revealed that the oxidation of CoCrMo is accelerated in the presence of carbonaceous species and organic compounds, and that the cells are involved in the release of metal ions. A biotribocorrosion device has been developed to evaluate the influence of degradation products on cellular metabolism. This comprehensive multidisciplinary study combined experimental techniques from electrochemistry, biology and tribology to highlight the importance of biomaterial surface chemistry on tribocorrosion resistance and cytotoxicity. Finally, an experimental methodology was proposed in this work, in order to better understand the interaction between simulated physiological fluids and biomaterials.
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Submitted on : Friday, October 2, 2020 - 2:47:40 PM
Last modification on : Saturday, October 3, 2020 - 3:59:20 AM


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  • HAL Id : tel-02956183, version 1


Amandine Impergre. Interactions entre CoCrMo et milieu cellulaire : De la corrosion à la tribocorrosion. Matériaux. Université de Lyon, 2019. Français. ⟨NNT : 2019LYSEI060⟩. ⟨tel-02956183⟩



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