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Unraveling the genetic architecture of traits in natural yeast populations

Abstract : Understanding the rules governing the astonishing diversity existing between individuals belonging to the same population has been one of the central role of biology. Recent years have seen the advent of genome-wide association studies to link genotype and phenotype at a population level. However, in most of the cases, an important amount of phenotypic variance remains unexplained and is called missing heritability. By combining the powerful model Saccharomyces cerevisiae, an elegant design borrowed to classical genetics and high-throughput strategies of genotyping and phenotyping, this work focused on increasing knowledge on the genetic architecture of traits and more precisely on some putative causes of this missing heritability at a species-wide level. Thus, we could quantify the effect of low frequency variants, obtain a global view of the genetic complexity spectrum as well as the impact of the genetic backgrounds on this complexity. Lastly, by using cutting edge long read sequencing strategies, a strong foundation for the identification of structural variants in natural population has been laid and allowed to a first view of their phenotypic effect.
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Téo Fournier. Unraveling the genetic architecture of traits in natural yeast populations. Genetics. Université de Strasbourg, 2019. English. ⟨NNT : 2019STRAJ073⟩. ⟨tel-02950439⟩

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