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Synthèse orthogonale de poly(triazole amide)s contenant des séquences codées synthétiques ou naturelles

Abstract : Poly(triazole amide)s are a class of sequence-defined polymers synthesized via a chemoselective iterative “AB+CD” approach on a solid support. This strategy allows to perfectly control the sequence of monomers, since the building blocks are added one by one. Moreover, the chemoselectivity of the coupling reactions enables to avoid the use of deprotection steps and to save time. In addition, the use of a solid support also minimizes the experiment time and facilitates the cleaning steps, thus reducing the total synthesis time. This synthesis pathway was used for the synthesis of different types of functional polymers. First of all, several oligomers such as structures based on alkyl or PEG chains were prepared, containing sequences of non-natural monomers that form a binary code. Those products were analyzed with two sequencing techniques: tandem mass spectrometry and nanopore single-chain analysis. A copper-free synthesis of this type of oligomers was also considered. Then, a new class of xeno nucleic acids (XNAs), peptide triazole nucleic acids (PTzNAs) was synthesized and studied. In particular, the hybridization properties of those natural sequence-containing polymers were investigated.
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https://tel.archives-ouvertes.fr/tel-02946969
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Submitted on : Wednesday, September 23, 2020 - 3:33:11 PM
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Fiers_Guillaume_2018_ED222.pdf
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Guillaume Fiers. Synthèse orthogonale de poly(triazole amide)s contenant des séquences codées synthétiques ou naturelles. Polymères. Université de Strasbourg, 2018. Français. ⟨NNT : 2018STRAF022⟩. ⟨tel-02946969⟩

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