, Sélection des alcynes à synthétiser par modélisation moléculaire
, Synthèse des alcynes fonctionnalisés avec le mime du NADPH
, Evaluation biologique des alcynes sur la DXR purifiée d'E
, Synthèse de triazoles bisubstrats : de potentiels inhibiteurs de la DXR
The Biological Formation of Cholesterol from Acetic Acid, J. Biol. Chem, vol.143, pp.297-299, 1942. ,
Nobel Lecture: The Biological Synthesis of Cholesterol, 1964. ,
Biosynthesis of Terpenes : Isopentenyl Pyrophosphates Isomerase, J. Biol. Chem, vol.235, issue.2, pp.326-333, 1960. ,
Biosynthesis of Terpenes. V. Formation of 5-Pyrophosphomevalonic Acid by Phosphomevalonic Kinase, Arch. Biochem. Biophys, vol.83, pp.259-267, 1959. ,
Enzymes of the Mevalonate Pathway of Isoprenoid Biosynthesis, Arch. Biochem. Biophys, vol.505, pp.131-143, 2011. ,
Prokaryotic Hopanoids: The Biosynthesis of the Bacteriohopane Skeleton. Formation of Isoprenic Units from Two Distinct Acetate Pools and a Novel Type of Carbon/carbon Linkage between a Triterpene and D-Ribose, Eur. J. Biochem, vol.175, pp.405-411, 1988. ,
A Mevalonate-Independent Route to Isopentenyl Diphosphate, Compr. Nat. Prod. Chem. Isoprenoids Incl. steroids carotenoids, vol.2, issue.2, pp.45-68, 1999. ,
Glyceraldehyde 3-Phosphate and Pyruvate as Precursors of Isoprenic Units in an Alternative Non-Mevalonate Pathway for Terpenoid Biosynthesis, J. Am. Chem. Soc, vol.118, issue.11, pp.2564-2566, 1996. ,
, Compr. Nat. Prod. Chem. Isoprenoids Incl. steroids carotenoids, pp.367-400, 1999.
, Isoprenoid Biosynthesis in Bacterial Pathogens. Microbiology, vol.158, pp.1389-1401, 2012.
Distribution of Mevalonate and Glyceraldehyde 3-Phosphate/pyruvate Routes for Isoprenoid Biosynthesis in Some Gram-Negative Bacteria and Mycobacteria, FEMS Microbiol. Lett, vol.164, pp.169-175, 1998. ,
Diversity of the Biosynthesis of the Isoprene Units, Nat. Prod. Rep, vol.20, pp.171-183, 2003. ,
Biosynthesis as a Novel Target for Antibacterial and Antiparasitic Drugs, Curr. Opin. Investig. Drugs, vol.5, issue.2, pp.154-162, 2004. ,
Development of Inhibitors of the 2C-Methyl-D-Erythritol 4-Phosphate (MEP) Pathway Enzymes as Potential Anti-Infective Agents, J. Med. Chem, vol.57, pp.9740-9763, 2014. ,
,
Identification of a Thiamin-Dependent Synthase in Escherichia Coli Required for the Formation of the 1-Deoxy-D-Xylulose 5-Phosphate Precursor to Isoprenoids, Thiamin, and Pyridoxol, Proc. Natl. Acad. Sci, vol.94, pp.12857-12862, 1997. ,
Cloning and Characterization of a Gene from Escherichia coli Encoding a Transketolase-like Enzyme That Catalyzes the Synthesis of D-1-Deoxyxylulose 5-Phosphate, a Common Precursor for Isoprenoid, Thiamin, and Pyridoxol Biosynthesis, Proc. Natl. Acad. Sci. USA, vol.95, pp.2105-2110, 1998. ,
Biosynthesis of Vitamin B6 : The Oxidation of 4-(Phosphohydroxy)-L-Threonine by PdxA, J. Am. Chem. Soc, vol.120, pp.1936-1937, 1998. ,
Biosynthesis of Vitamin B6 : Enzymatic Conversion of 1-Deoxy-D-Xylulose-5-Phosphate to Pyridoxol Phosphate, J. Am. Chem. Soc, vol.121, pp.7722-7723, 1999. ,
Structure-Activity Relationships of Compounds Targeting Mycobacterium tuberculosis 1-Deoxy-D-Xylulose 5-Phosphate Synthase, Bioorg. Med. Chem. Lett, vol.18, pp.5320-5323, 2008. ,
Properties and Inhibition of the First Two Enzymes of the Non-Mevalonate Pathway of Isoprenoid Biosynthesis, Biochem. Soc. Trans, vol.28, issue.6, p.792, 2000. ,
The Herbicide Ketoclomazone Inhibits 1-Deoxy-D-Xylulose 5-Phosphate Synthase in the 2-C-Methyl-D-Erythritol 4-Phosphate Pathway and Shows Antibacterial Activity against Haemophilus influenzae, J. Antibiot, vol.63, pp.583-588, 2010. ,
Antimicrobial N-(2-Chlorobenzyl)-Substituted Hydroxamate Is an Inhibitor of 1-Deoxy-D-Xylulose 5-Phosphate Synthase, Chem. Commun, issue.49, pp.5535-5537, 2013. ,
Revealing Substrate Promiscuity of 1-Deoxy-D-Xylulose 5-Phosphate Synthase, Org. Lett, issue.20, pp.4748-4751, 2009. ,
5-Hydroxypentane-2,3-Dione (Laurencione), a Bacterial Metabolite of 1-Deoxy-D-Threo-Pentulose, Tetrahedron Lett, vol.39, pp.6185-6188, 1998. ,
, ChemBioChem, vol.2013, issue.11, pp.1309-1315
Selective Inhibition of E. coli 1-Deoxy-D-Xylulose-5-Phosphate Synthase by Acetylphosphonates, Med. Chem. Commun, vol.2012, issue.1, p.65 ,
,
Targeting DXP Synthase in Human Pathogens: Enzyme Inhibition and Antimicrobial Activity of Butylacetylphosphonate, J. Antibiot, vol.67, pp.77-83, 2014. ,
Chemical Science DXS Guided by Spin-Diffusion-Based NMR spectroscopy, Chem. Sci, vol.5, pp.3543-3551, 2014. ,
Rhodobacter Capsulatus 1-Deoxy-D-Xylulose 5-Phosphate Synthase : Steady-State Kinetics and Substrate Binding, Biochemistry, vol.42, pp.1140-1149, 2003. ,
A 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase Catalyzing the Formation of 2-C-Methyl-D-Erythritol 4-Phosphate in an Alternative Nonmevalonate Pathway for Terpenoid Biosynthesis, Proc. Natl. Acad. Sci, vol.95, pp.9879-9884, 1998. ,
Structure of 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase in a Quaternary Complex with a Magnesium Ion, NADPH and the Antimalarial Drug Fosmidomycin, Acta Cryst, vol.63, pp.466-470, 2007. ,
Etudes in Silico et Expérimentale de La DXR et Synthèse de D-et L-GAP Énantiomériquement Purs, 2016. ,
The Crystal Structure of E.coli 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase in a Ternary Complex with the Antimalarial Compound Fosmidomycin and NADPH Reveals a Tight-Binding Closed Enzyme Conformation, J. Mol. Biol, vol.345, issue.1, pp.115-127, 2005. ,
Crystal Structure of 1-Deoxy-D -Xylulose-5-Phosphate Reductoisomerase , a Crucial Enzyme in the Non-Mevalonate Pathway of Isoprenoid Biosynthesis, J. Biol, vol.277, issue.7, pp.5378-5384, 2002. ,
Crystal Structure of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase from Zymomonas mobilis at 1.9-Å Resolution, Biochim. Biophys. Acta, vol.1698, pp.37-44, 2004. ,
The 1.9 Å Resolution Structure of Mycobacterium tuberculosis 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase, a Potential Drug Target, Acta Cryst, vol.62, pp.807-813, 2006. ,
URL : https://hal.archives-ouvertes.fr/inserm-00670601
Structures of Mycobacterium tuberculosis 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase Provide New Insights into Catalysis, J. Biol. Chem, issue.27, pp.19905-19916, 2007. ,
Mechanism and Inhibition of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase, Bioorg. Chem, vol.57, pp.171-185, 2014. ,
Structure of 1-Deoxy-D-Xylulose Reductoisomerase Complexed with Cofactors : Implications Flexible Loop Movement upon Substrate, J. Biochem, vol.131, pp.313-317, 2002. ,
Isoprenoid Biosynthesis via the Methylerythritol Phosphate Pathway. Mechanistic Investigations of the 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase, Eur. J. Biochem, vol.269, pp.4446-4457, 2002. ,
Synthesis and Evaluation of 1-Deoxy-D-Xylulose 5-Phosphoric Acid Analogues as Alternate Substrates for Methylerythritol Phosphate Synthase, J. Org. Chem, vol.70, 1978. ,
Mechanistic Studies with 2-C-Methyl-D-Erythritol 4-Phosphate Synthase from Escherichia coli, Biochemistry, vol.44, pp.8360-8368, 2005. ,
The Chemical Mechanism of D-1-Deoxyxylulose-5-Phosphate Reductoisomerase from Escherichia coli, Angew. Chem. Int. Ed, vol.46, issue.26, pp.4926-4929, 2007. ,
A Secondary Kinetic Isotope Effect Study of the 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase-Catalyzed Reaction: Evidence for a Retroaldol-Aldol Rearrangement, J. Am. Chem. Soc, vol.131, pp.2048-2049, 2009. ,
Stereochemistry of the Reduction Step Mediated by Recombinant 1-Deoxy-D-Xylulose 5-Phosphate Isomeroreductase, Org. Lett, issue.6, pp.921-923, 1999. ,
Stereochemical Course of the Reduction Step in the Formation of 2-C-Methylerythritol from the Terpene Precursor 1-Deoxyxylulose in Higher Plants, Chem. Commun, pp.1127-1128, 1999. ,
Biosynthesis of Terpenoids : 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase from Escherichia coli Is a Class B Dehydrogenase, FEBS Lett, vol.465, pp.157-160, 2000. ,
Substrate Analogs for the Investigation of Deoxyxylulose 5-Phosphate Reductoisomerase Inhibition: Synthesis and Evaluation, Bioorg. Med. Chem. Lett, vol.14, pp.5309-5312, 2004. ,
Study of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase: Synthesis and Evaluation of Fluorinated Substrate Analogues, Org. Lett, vol.6, issue.20, pp.3625-3628, 2004. ,
3R,4S)-3,4,5-Trihydroxy-4-Methylpentylphosphonic Acid, an Isosteric Phosphonate Analogue of 2-C-Methyl-D-Erythritol 4-Phosphate, a Key Intermediate in the New Pathway for Isoprenoid Biosynthesis, Tetrahedron Lett, vol.45, issue.3, pp.519-521, 2004. ,
Synthesis of ( 3 R , 4 S ) -3 , 4-Dihydroxy-5-Oxohexylphosphonic Acid , an Isosteric Analogue of 1-Deoxy-D -Xylulose 5-Phosphate , the Substrate of the 1-Deoxy-D -Xylulose 5-Phosphate Reducto-Isomerase, Org. Biomol. Chem, vol.1, pp.4367-4372, 2003. ,
Synthesis and Evaluation of 1-Deoxy-D -Xylulose 5-Phosphate Analogues as Chelation-Based Inhibitors of Methylerythritol Phosphate Synthase, J. Org. Chem, vol.70, pp.9955-9959, 2005. ,
Structure of 4-Diphosphocytidyl-2-C-Methylerythritol Synthetase Involved in Mevalonate-Independent Isoprenoid Biosynthesis, Nat. Struct. Biol, vol.8, issue.7, pp.641-648, 2001. ,
Structure of a Tetragonal Crystal Form of Escherichia coli 2-C-Methyl-D-Erythritol 4-Phosphate Cytidylyltransferase, Acta Crystal. -Sect. D Biol. Crystallogr, vol.59, pp.607-610, 2003. ,
Kinetic Analysis of Escherichia Coli 2-C-Methyl-D-Erythritol-4-Phosphate Cytidyltransferase, Wild Type and Mutants, Reveals Roles of Active Site Amino, Biochemistry, vol.43, pp.12189-12197, 2004. ,
Structural and Functional Studies of Mycobacterial IspD Enzymes. Acta Crystal, pp.403-414, 2011. ,
Druggability of the Enzymes of the Non-Mevalonate-Pathway, Drug Discov. Today, vol.2013, pp.1-7 ,
Functional Expression and Characterization of EryA , the Erythritol Kinase of Brucella abortus, and Enzymatic Synthesis of L-Erythritol-4-Phosphate, Bioorg. Med. Chem. Lett, vol.13, pp.737-739, 2003. ,
, Inhibitors of the Herbicidal Target IspD : Allosteric Site Binding, vol.50, pp.7931-7935, 2011.
,
Synthesis and Evaluation of Hydroxyazolopyrimidines as Herbicides ; the Generation of Amitrole in Planta, Pest. Manag. Sci, vol.72, pp.2254-2272, 2016. ,
Agrochemicals Against Malaria, Sleeping Sickness, Leishmaniasis and Chagas Disease, PLoS Negl. Trop. Dis, vol.2012, issue.10, p.1805 ,
Pseudilins : Halogenated , Allosteric Inhibitors of the Non-Mevalonate Pathway Enzyme IspD, Angew. Chem, vol.53, pp.2235-2239, 2014. ,
A Second Target of the Antimalarial and Antibacterial Agent Fosmidomycin Revealed by Cellular Metabolic Profiling, Biochemistry, vol.50, pp.3570-3577, 2011. ,
A Chemical Rescue Screen Identifies a Plasmodium falciparum Apicoplast Inhibitor Targeting MEP Isoprenoid Precursor Biosynthesis, Antimicrob. Agents Chemother, vol.59, issue.1, pp.356-364, 2015. ,
Plasmodium IspD (2-C-Methyl -D-erythritol 4-Phosphate Cytidyltransferase), an Essential and Druggable Antimalarial Target, ACS Infect. Dis, vol.1, pp.157-167, 2015. ,
, Molecular Mechanism of Action of Antimalarial Benzoisothiazolones : Species-Selective Inhibitors of the Plasmodium Spp. MEP Pathway Enzyme, pp.1-12, 2016.
Identification and Validation of a Novel Lead Compound Targeting 4-Diphosphocytidyl-2-C-Methylerythritol Synthetase ( IspD ) of Mycobacteria, Eur. J. Pharmacol, vol.694, pp.45-52, 2012. ,
Molecular Functions of Conserved Aspects of the GHMP Kinase Family, Biochemistry, vol.43, pp.14594-14601, 2004. ,
GHMP Kinases -Structures, Mechanisms and Potential for Therapeutically Relevant Inhibition, Curr. Enzym. Inhib, vol.3, pp.77-94, 2007. ,
, Biosynthesis of Isoprenoids : Crystal Structure of 4-Diphosphocytidyl-2C-Methyl-D-Erythritol Kinase. Proc. Natl. Acad. Sci, vol.100, pp.1-6, 2003.
Synthesis and Biological Evaluation of Pyrazolopyrimidines as Potential Antibacterial Agents, Bioorg. Med. Chem. Lett, vol.25, pp.5699-5704, 2015. ,
,
Non phosphonate Inhibitors of the IspE Protein, a Kinase in the Non-Mevalonate Pathway for Isoprenoid Biosynthesis and a Potential Target for Antimalarial Therapy, ChemMedChem, vol.2, pp.806-810, 2007. ,
, Inhibitors of the Kinase IspE : Structure -Activity Relationships and Co-Crystal Structure Analysis, vol.6, pp.2719-2730, 2008.
5-Substituted ( 1-Thiolan-2-Yl ) Cytosines as Inhibitors of A. aeolicus and E. coli IspE Kinases : Very Different Affinities to Similar Substrate-Binding Sites, Eur. J. Org. Chem, pp.880-887, 2013. ,
Exploring the Ribose Sub-Pocket of the Substrate-Binding Site in Escherichia coli IspE : Structure-Based Design, Synthesis, and Biological Evaluation of Cytosines and Cytosine Analogues, Eur. J. Org. Chem, pp.3278-3287, 2012. ,
Bioconjugates to Specifically Render Inhibitors Water-Soluble, Soft Matter, vol.6, pp.88-91, 2010. ,
Imidazole-and Benzimidazole-Based Inhibitors of the Kinase IspE: Targeting the Substrate-Binding Site and the Triphosphate-Binding Loop of the ATP Site, Eur. J. Org. Chem, pp.1068-1079, 2013. ,
,
Identification of 1, 3-Diiminoisoindoline Carbohydrazides as Potential Antimalarial Candidates, ChemMedChem, vol.7, pp.151-158, 2012. ,
Synthesis and Characterization of Cytidine Derivatives That Inhibit the Kinase IspE of the Non-Mevalonate Pathway for Isoprenoid Biosynthesis, ChemMedChem, vol.3, pp.91-101, 2008. ,
Bernet, B. 8-Substituted , Syn -Configured Adenosine Derivatives as Potential Inhibitors of the Enzyme IspE from the Non-Mevalonate Pathway of Isoprenoid Biosynthesis, Eur. J. Org. Chem, pp.7276-7286, 2015. ,
Bioorganic & Medicinal Chemistry Identification of Novel Small Molecule Inhibitors of 4-Diphosphocytidyl-2-C -Methyl-D -Erythritol ( CDP-ME ) Kinase of Gram-Negative Bacteria, Bioorg. Med. Chem, vol.19, pp.5886-5895, 2011. ,
IspE Inhibitors Identified by a Combination of In Silico and In Vitro High-Throughput Screening, PLoS One, vol.7, issue.4, pp.1-16, 2012. ,
Expression and Characterization of Soluble Kinase from Bacterial Pathogens, Chem. Biol, vol.16, pp.1230-1239, 2009. ,
Crystal Structure of 4-Diphosphocytidyl-2-C-Methyl-D-Erythritol Kinase ( IspE ) from Mycobacterium tuberculosis, FASEB J, vol.2017, issue.5, pp.1577-1584 ,
Studies on the Nonmevalonate Pathway : Formation of 2-C-Methyl-D-Erythritol 2, 4-Cyclodiphosphate from 2-Phospho-4-(Cytidine 5'-diphospho)-2-C-Methyl-D-Erythritol, Tetrahedron Lett, vol.41, pp.3395-3398, 2000. ,
Biosynthesis of Terpenoids: YgbB Protein Converts 4-Diphosphocytidyl-2C-Methyl-D-Erythritol 2-Phosphate to 2C-Methyl-D-Erythritol 2,4-Cyclodiphosphate, Proc. Natl. Acad. Sci. USA, issue.6, pp.2486-2490, 2000. ,
Structure of 2C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Synthase Involved in Mevalonate-Independent Biosynthesis of Isoprenoids, J. Mol. Biol, vol.316, issue.1, pp.79-88, 2001. ,
Structure and Mechanism of 2-C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase: An Enzyme in the Mevalonate-Independent Isoprenoid Biosynthetic Pathway, J. Biol. Chem, issue.10, pp.8667-8672, 2002. ,
Structure of 2C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase: An Essential Enzyme for Isoprenoid Biosynthesis and Target for Antimicrobial Drug Development, Proc. Natl. Acad. Sci. USA, pp.6591-6596, 2002. ,
Structure and Catalytic Mechanism of 2-C-Methyl-D-Erythritol 2,4-Cyclodiphosphate (MECDP) Synthase, an Enzyme in the Non-Mevalonate Pathway of Isoprenoid Synthesis, vol.59, pp.23-31, 2003. ,
Structure of 2C-Methyl-D-Erythrol-2,4-Cyclodiphosphate Synthase from Haemophilus influenzae: Activation by Conformational Transition, Proteins Struct. Funct. Genet, vol.49, pp.135-138, 2002. ,
Structure of 2C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Synthase from Shewanella oneidensis at 1.6 Å: Identification of Farnesyl Pyrophosphate Trapped in a Hydrophobic Cavity, Acta Crystal, vol.60, pp.1949-1957, 2004. ,
The Identification of Isoprenoids That Bind in the Intersubunit Cavity of Escherichia coli 2C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Synthase by, Complementary Biophysical Methods. Acta Crystal, vol.61, pp.45-52, 2005. ,
2C-Methyl-D-Erythritol 4-Phosphate Enhances and Sustains Cyclodiphosphate Synthase IspF Activity, ACS Chem. Biol, vol.7, pp.1702-1710, 2012. ,
Crystal Structures of IspF from Plasmodium falciparum and Burkholderia cenocepacia: Comparisons Inform Antimicrobial Drug Target Assessment, BMC Struct. Biol, vol.14, issue.1, pp.1-12, 2014. ,
Fluorescent Inhibitors for IspF, an Enzyme in the Non-Mevalonate Pathway for Isoprenoid Biosynthesis and a Potential Target for Antimalarial Therapy, Angew. Chem, vol.45, pp.1069-1074, 2006. ,
Structure-Based Design and Synthesis of the First Weak Non-Phosphate Inhibitors for IspF, an Enzyme in the Non-Mevalonate Pathway of Isoprenoid Biosynthesis, Helv. Chim. Acta, vol.90, pp.1043-1068, 2007. ,
Thiazolopyrimidine Inhibitors of 2-Methylerythritol 2,4-Cyclodiphosphate Synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparum, ChemMedChem, vol.5, pp.1092-1101, 2010. ,
Synthesis and Evaluation of Stable Substrate Analogs as Potential Modulators of Cyclodiphosphate Synthase IspF, Med. Chem. Commun, vol.4, pp.130-134, 2013. ,
Synthesis of Methylerythritol Phosphate Analogues and Their Evaluation as Alternate Substrates for IspDF and IspE from Agrobacterium tumefaciens, J. Org. Chem, vol.79, pp.9170-9178, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-02064012
Aryl Bis-Sulfonamide Inhibitors of IspF from Arabidopsis thaliana and Plasmodium falciparum, ChemMedChem, pp.2090-2098, 2015. ,
Identification of gcpE as a Novel Gene of the 2-C-Methyl-D-Erythritol 4-Phosphate Pathway for Isoprenoid Biosynthesis in Escherichia coli, FEBS Lett, vol.488, pp.170-173, 2001. ,
Isoprenoid Biosynthesis through the Methylerythritol Phosphate Pathway: The (E)4-Hydroxy-3-Methylbut-2-Enyl Diphosphate Synthase (GcpE) Is a, Angew. Chem. -Int. Ed, issue.22, pp.4337-4339, 2002. ,
Iron-Sulfur Clusters : Nature's Modular, Multipurpose Structures, Science, vol.277, pp.653-659, 2007. ,
Isoprenoid Biosynthesis in Plant Chloroplasts via the MEP Pathway: Direct Thylakoid/ferredoxin-Dependent Photoreduction of GcpE/IspG, FEBS Lett, vol.580, pp.1547-1552, 2006. ,
URL : https://hal.archives-ouvertes.fr/hal-00091768
Structure of the E-1-Hydroxy-2-Methyl-but-2-Enyl-4-Diphosphate Synthase (GcpE) from Thermus thermophilus, FEBS Lett, vol.585, pp.447-451, 2011. ,
Biosynthesis of Isoprenoids: Crystal Structure of the, Cluster Protein IspG. J. Mol. Biol, vol.404, pp.600-610, 2010. ,
Structure of the GcpE (IspG)-MEcPP Complex from Thermus thermophilus, Biochem. Biophys. Res. Commun, vol.458, pp.246-250, 2015. ,
Atomic-Resolution Structures of Discrete Stages on the Reaction Coordinate of the [Fe4S4] Enzyme IspG (GcpE), J. Mol. Biol, vol.427, pp.2220-2228, 2015. ,
Organometallic Mechanism of Action and Inhibition of the 4Fe-4S Isoprenoid Biosynthesis Protein GcpE (IspG), Proc. Natl. Acad. Sci, pp.11189-11193, 2010. ,
Biologically Related Iron-Sulfur Clusters as Reaction Centers. Reduction of Acetylene to Ethylene in Systems Based on, J. Inorg. Biochem, vol.11, pp.213-227, 1979. ,
Raman Spectra of the Adducts of Reduced Species of [Fe4S4(SPh)4] 2-and [Mo2Fe6S8(SPh)9] 3-with Acetylene, Chem. Lett, pp.613-616, 1987. ,
Function and Inhibition of the Two-and Three-Domain 4Fe-4S IspG Proteins, Proc. Natl. Acad. Sci, vol.109, pp.8558-8563, 2012. ,
Characterization of 4-Hydroxy-3-Methylbut-2-En-1-Yl Diphosphate Synthase ( IspG ) from Plasmodium vivax and It 's Potential as an Antimalarial Drug Target, Int. J. Biol. Macromol, vol.96, pp.466-473, 2017. ,
Isoprenoid Biosynthesis via the Methylerythritol Phosphate Pathway: The (E)-4-Hydroxy-3-Methylbut-2-Enyl Diphosphate Reductase (LytB/IspH) from Escherichia coli Is a, Protein. FEBS Lett, vol.541, pp.115-120, 2003. ,
Structure of Active IspH Enzyme from Escherichia coli Provides Mechanistic Insights into Substrate Reduction, Angew. Chem. -Int. Ed, vol.48, pp.5756-5759, 2009. ,
Structure of (E)-4-Hydroxy-3-Methyl-but-2-Enyl Diphosphate Reductase, the Terminal Enzyme of the Non-Mevalonate Pathway, J. Am. Chem. Soc, vol.130, pp.17206-17207, 2008. ,
IspH Protein of Escherichia coli: Studies on Iron-Sulfur Cluster Implementation and Catalysis, J. Am. Chem. Soc, vol.126, pp.12847-12855, 2004. ,
Bioorganometallic Mechanism of Action, and Inhibition, of IspH, Proc. Natl. Acad. Sci, pp.4522-4527, 2010. ,
Crystal Structures of Mutant IspH Proteins Reveal a Rotation of the Substrate's Hydroxymethyl Group during Catalysis, J. Mol. Biol, vol.416, pp.1-9, 2012. ,
Discovery of Acetylene Hydratase Activity of the Iron-sulphur Protein IspH, Nat. Commun, vol.3, pp.1-8, 2012. ,
Inhibition of the 4Fe-4S -Cluster-Containing Protein IspH ( LytB ): Electron Paramagnetic Resonance , Metallacycles , and Mechanisms, J. Am. Chem. Soc, vol.132, pp.6719-6727, 2010. ,
Insights into the Binding of Pyridines to the Iron-Sulfur Enzyme IspH, J. Am. Chem. Soc, vol.136, pp.7926-7932, 2014. ,
Synthesis of Analogues of (E)-1-Hydroxy-2-Methylbut-2-Enyl 4-Diphosphate, an Isoprenoid Precursor and Human ?? T Cell Activator, J. Org. Chem, vol.73, pp.1365-1370, 2008. ,
Biosynthesis of Isoprene Units: Mössbauer Spectroscopy of Substrate and Inhibitor Binding to the, Angew. Chem, vol.50, pp.11976-11979, 2011. ,
Inhibition of IspH, a [4Fe-4S] 2+ Enzyme Enzyme Involved in the Biosynthesis of Isoprenoids via the Methylerythritol Phosphate Pathway, J. Am. Chem. Soc, vol.135, pp.1816-1822, 2013. ,
Inhibition of the 4Fe-4S Proteins IspG and IspH: An EPR, ENDOR and HYSCORE Investigation, Chem. Sci, vol.5, pp.1642-1649, 2014. ,
Structures of Fluoro, Amino, and Thiol Inhibitors Bound to the [Fe4S4] Protein IspH, Angew. Chem. -Int. Ed, vol.52, pp.2118-2121, 2013. ,
Are Free Radicals Involved in IspH Catalysis? An EPR and Crystallographic Investigation, J. Am. Chem. Soc, vol.134, pp.11225-11234, 2012. ,
Isoprenoid Biosynthesis : Ferraoxetane or Allyl Anion Mechanism for IspH Catalysis ?, Angew. Chem, vol.52, pp.6522-6525, 2013. ,
Isoprenoid Biosynthesis in Pathogenic Bacteria: Nuclear Resonance Vibrational Spectroscopy Provides Insight into the Unusual, Angew. Chem, vol.54, pp.12584-12587, 2015. ,
Isoprenoid Biosynthesis via the Methylerythritol Phosphate Pathway: GcpE and LytB, Two Novel Iron-Sulphur Proteins, Comptes Rendus Chim, vol.10, pp.748-755, 2007. ,
Bioorganometallic Chemistry with IspG and IspH: Structure, Function, and Inhibition of the [Fe4S4] Proteins Involved in Isoprenoid Biosynthesis, Angew. Chem. -Int ,
, , vol.53, pp.4294-4310, 2014.
Microbial Isoprenoid Biosynthesis and Human ?? T Cell Activation, FEBS Lett, vol.544, pp.4-10, 2003. ,
Human Neutrophil Clearance of Bacterial Pathogens Triggers Anti-Microbial ?? T Cell Responses in Early Infection, PLoS Pathog, vol.7, issue.5, pp.1-13, 2011. ,
, Stratégie de l'OMS pour mettre fin à la tuberculose, OMS, 2017.
, , 2016.
In Vitro and in Vivo Antibacterial Activities of FR-31564, a New Phosphonic Acid Antibiotic, J. Antibiot, vol.33, issue.1, pp.36-43, 1980. ,
FR-31564, A New Phosphonic Acid Antibiotic:bacterial Resistance and Membrane Permeability, J. Antibiot, vol.33, issue.1, pp.44-48, 1980. ,
, Studies on New Phosphonic Acid Antibiotics. III. Isolation and Characterization of FR-31564
Studies on New Phosphonic Acid Antibiotics. IV. Structure Determination of FR-33289, FR-31564 and FR-32863, J Antibiot, vol.33, issue.1, pp.29-35, 1980. ,
Studies on New Phosphonic Acid Antibiotics. I. FR-900098, Isolation and Characterization, J. Antibiot, vol.33, issue.1, pp.13-17, 1980. ,
Inhibition of Bacterial Isoprenoid Synthesis by Fosmidomycin, a Phosphonic Acid-Containing Antibiotic, J. Antimicrob. Chemother, vol.24, pp.131-145, 1989. ,
Specific Inhibitor of 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase in the Nonmevalonate Pathway for Terpenoid Biosynthesis, Tetrahedron Lett, vol.39, pp.7913-7916, 1998. ,
, Steady-State Kinetic Analysis and Substrate Binding, vol.41, pp.236-243, 2002.
Inhibitors of the Nonmevalonate Pathway of Isoprenoid Biosynthesis as Antimalarial Drugs, Science, vol.285, pp.1573-1575, 1999. ,
, Fosmidomycin for Malaria. Lancet, vol.360, pp.1941-1942, 2002.
, In Vitro and In Vivo Synergy of Fosmidomycin , a Novel Antimalarial Drug , with Clindamycin. Antimicrob. Agents Chemother, vol.46, issue.9, pp.2889-2894, 2002.
,
,
Fosmidomycin-Clindamycin for the Treatment of Plasmodium Falciparum Malaria, J. Infect. Dis, vol.190, issue.9, pp.1534-1540, 2004. ,
Fosmidomycin Resistance in Adenylate Cyclase Deficient (Cya) Mutants of Escherichia coli, Biosci. Biotechnol. Biochem, vol.67, issue.9, pp.2030-2033, 2003. ,
Dxr Is Essential in Mycobacterium tuberculosis and Fosmidomycin Resistance Is due to a Lack of Uptake, BMC Microbiol, vol.8, issue.78, pp.1-9, 2008. ,
,
Cloning of a Gene from Escherichia coli That Confers Resistance to Fosmidomycin as a Consequence of Amplification, Gene, vol.175, pp.83-87, 1996. ,
Resistance of the Burkholderia cepacia Complex to Fosmidomycin and Fosmidomycin Derivatives, Int. J. Antimicrob. Agents, vol.38, issue.3, pp.261-264, 2011. ,
Isoprenoid Biosynthesis as a Target for Antibacterial and Antiparasitic Drugs: Phosphonohydroxamic Acids as Inhibitors of Deoxyxylulose Phosphate Reducto-Isomerase ,
, Biochem. J, vol.386, pp.127-135, 2005.
Modifications around the Hydroxamic Acid Chelating Group of Fosmidomycin, an Inhibitor of the Metalloenzyme 1-Deoxyxylulose 5-Phosphate Reductoisomerase (DXR), Bioorg. Med. Chem. Lett, vol.22, pp.6563-6567, 2012. ,
Coordination Chemistry Based Approach to Lipophilic Inhibitors of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase, J. Med. Chem, vol.52, pp.6539-6542, 2009. ,
Substitution of the Phosphonic Acid and Hydroxamic Acid Functionalities of the DXR Inhibitor FR900098: An Attempt to Improve the Activity against Mycobacterium tuberculosis, Bioorg. Med. Chem. Lett, vol.21, pp.5403-5407, 2011. ,
A Fragment-Based Approach to Understanding Inhibition of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase, ChemBioChem, vol.6, pp.1866-1874, 2005. ,
Evaluation of Fosmidomycin Analogs as Inhibitors of the Synechocystis Sp. PCC6803 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase, Bioorg. Med. Chem, vol.14, pp.2375-2385, 2006. ,
Inhibition of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase by Lipophilic Phosphonates: SAR, QSAR, and Crystallographic Studies, J. Med. Chem, vol.54, pp.4721-4734, 2011. ,
Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/lipophilic Phosphonate Complexes, ACS Med. Chem. Lett, vol.2, pp.165-170, 2011. ,
Binding Modes of Reverse Fosmidomycin Analogs toward the Antimalarial Target IspC, J. Med. Chem, vol.57, pp.8827-8838, 2014. ,
From Zn to Mn: The Study of Novel Manganese-Binding Groups in the Search for New Drugs against Tuberculosis, Chem. Biol. Drug Des, vol.77, pp.117-123, 2011. ,
Functionalized Phosphanyl-Phosphonic Acids as Unusual Complexing Units as Analogues of Fosmidomycin, Eur. J. Org. Chem, vol.2012, pp.3237-3248 ,
URL : https://hal.archives-ouvertes.fr/hal-00993938
Fosmidomycin Analogues with N-Hydroxyimidazole and N-Hydroxyimidazolone as a Chelating Unit, p.23770 ,
URL : https://hal.archives-ouvertes.fr/hal-01100662
, Propylphosphonic Acid (FR-900098), vol.3, pp.111-118, 1982.
Synthesis of Alpha-Substituted Fosmidomycin Analogues as Highly Potent Plasmodium Falciparum Growth Inhibitors, Bioorg. Med. Chem. Lett, vol.16, pp.1888-1891, 2006. ,
Synthesis and Biological Evaluation of Cyclopropyl Analogues of Fosmidomycin as Potent Plasmodium Falciparum Growth Inhibitors, J. Med. Chem, vol.49, pp.2656-2660, 2006. ,
Synthesis of ?-Aryl-Substituted and Conformationally Restricted Fosmidomycin Analogues as Promising ,
Synthesis and Evaluation of ?-Halogenated Analogues of 3-(Acetylhydroxyamino)propylphosphonic Acid (FR900098) as Antimalarials, J. Med. Chem, vol.53, pp.5342-5346, 2010. ,
, D. Preparation of Gem-Difluorinated Retrohydroxamic-Fosmidomycin. Arkivoc, vol.4, pp.117-126, 2015.
Alpha-Heteroatom Derivatised Analogues of FR900098 as Antimalarials, J. Med. Chem, vol.56, pp.376-380, 2013. ,
Synthesis and Bioactivity of ?-Substituted Fosmidomycin Analogues Targeting 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase, J. Med. Chem, vol.58, pp.2988-3001, 2015. ,
Targeting an Aromatic Hotspot in Plasmodium Falciparum 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase with ?-Arylpropyl Analogues of Fosmidomycin, ChemMedChem, vol.11, pp.1-14, 2016. ,
Synthesis and Antimalarial Activity of Chain Substituted Pivaloyloxymethyl Ester Analogues of Fosmidomycin and FR900098, Bioorg. Med. Chem, vol.14, pp.5121-5135, 2006. ,
Arylmethyl Substituted Derivatives of Fosmidomycin: Synthesis and Antimalarial Activity, Eur. J. Med. Chem, vol.41, pp.1385-1397, 2006. ,
Conformationally Restrained Aromatic Analogues of Fosmidomycin and FR900098, Arch. Pharm, vol.340, pp.339-344, 2007. ,
Synthesis and Antiplasmodial Activity of Highly Active Reverse Analogues of the Antimalarial Drug Candidate Fosmidomycin, ChemMedChem, vol.5, pp.1673-1676, 2010. ,
Reverse Fosmidomycin Derivatives against the Antimalarial Drug, J. Med. Chem, vol.54, pp.6796-6802, 2011. ,
Substituted ?-Oxa Isosteres of Fosmidomycin: Synthesis and Biological Evaluation, J. Med. Chem, vol.55, pp.6566-6575, 2012. ,
IspC as Target for Antiinfective Drug Discovery: Synthesis, Enantiomeric Separation, and Structural Biology of Fosmidomycin Thia Isosters, J. Med. Chem, vol.56, pp.8151-8162, 2013. ,
Isoprenoid Biosynthesis via the Methylerythritol Phosphate Pathway: Structural Variations around Phosphonate Anchor and Spacer of Fosmidomycin, a Potent Inhibitor of Deoxyxylulose Phosphate Reductoisomerase, J. Org. Chem, vol.75, pp.3203-3207, 2010. ,
The Effect of Chain Length and Unsaturation on Mtb Dxr Inhibition and Antitubercular Killing Activity of FR900098 Analogs, Bioorg. Med. Chem. Lett, vol.24, pp.649-653, 2014. ,
Antimalarial and Structural Studies of Pyridine-Containing Inhibitors of 1-Deoxyxylulose-5-Phosphate Reductoisomerase, ACS Med. Chem. Lett, vol.4, pp.278-282, 2013. ,
Synthesis of Functionalized Cinnamaldehyde Derivatives by an Oxidative Heck Reaction and Their Use as Starting Materials for Preparation of Mycobacterium Tuberculosis 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase Inhibitors, J. Org. Chem, vol.76, pp.8986-8998, 2011. ,
Carboxylic Acid Analogues of Fosmidomycin, J. Chem. Sci, vol.58, pp.457-461, 2003. ,
Studies Addressing the Importance of Charge in the Binding of Fosmidomycin-like Molecules to Deoxyxylulosephosphate Reductoisomerase, ChemMedChem, vol.3, pp.1232-1241, 2008. ,
Acylated Sulfonamide Congeners of Fosmidomycin Lack Any Inhibitory Activity against DXR, Bioorg. Med. Chem. Lett, vol.25, pp.1577-1579, 2015. ,
Synthesis of Tetrazole Analogues of Phosphonohydroxamic Acids: An Attempt to Improve the Inhibitory Activity against the DXR, Bioorg. Med. Chem. Lett, vol.23, pp.1643-1647, 2013. ,
Diaryl Ester Prodrugs of FR900098 with Improved in vivo Antimalarial Activity, Bioorg. Med. Chem. Lett, vol.11, pp.833-835, 2001. ,
Acyloxyalkyl Ester Prodrugs of FR900098 with Improved in Vivo Antimalarial Activity, Arch. Pharm, vol.13, pp.2163-2166, 2003. ,
Alkoxycarbonyloxyethyl Ester Prodrugs of FR900098 with Improved in Vivo Antimalarial Activity, Arch. Pharm. Chem. Life Sci, vol.338, pp.305-314, 2005. ,
Double Ester Prodrugs of FR900098 Display Enhanced in-Vitro Antimalarial Activity, Arch. Pharm. Chem. Life Sci, vol.340, pp.667-669, 2007. ,
Prodrugs of Reverse Fosmidomycin Analogues, J. Med. Chem, vol.58, pp.2025-2035, 2015. ,
Antibacterial and Antitubercular Activity of Fosmidomycin, FR900098, and Their Lipophilic Analogs, Bioorg. Med. Chem. Lett, vol.21, pp.6973-6976, 2011. ,
Lipophilic Prodrugs of FR900098 Are Antimicrobial against Francisella Novicida In Vivo and In Vitro and Show GlpT Independent Efficacy, PLoS One, vol.7, issue.10, pp.1-12, 2012. ,
Growth Inhibition of Mycobacterium Smegmatis by Prodrugs of Deoxyxylulose Phosphate Reducto-Isomerase Inhibitors, Promising Anti-Mycobacterial Agents, Eur. J. Med. Chem, vol.51, pp.277-285, 2012. ,
Synthesis and Antimalarial Evaluation of Prodrugs of Novel Fosmidomycin Analogues, Bioorg. Med. Chem. Lett, vol.25, pp.2112-2116, 2015. ,
Novel Deoxyxylulosephosphate-Reductoisomerase Inhibitors: Fosmidomycin Derivatives with Spacious Acyl Residues, Arch. Pharm. Chem. Life Sci, vol.340, pp.483-490, 2007. ,
Towards New Antimalarial Drugs: Synthesis of Non-Hydrolyzable Phosphate Mimics as Feed for a Predictive QSAR Study on 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase Inhibitors, Chem. Biodivers, vol.5, pp.643-656, 2008. ,
Synthesis and Evaluation of Phosphonated N -Heteroarylcarboxamides as DOXP-Reductoisomerase ,
, Bioorg. Med. Chem, vol.19, pp.1321-1327, 2011.
Exploring DOXP-Reductoisomerase Binding Limits Using Phosphonated N-Aryl and N-Heteroarylcarboxamides as DXR Inhibitors, Bioorg. Med. Chem, vol.21, pp.4332-4341, 2013. ,
Design of Potential Bisubstrate Inhibitors against Mycobacterium Tuberculosis (Mtb) 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase (Dxr)-Evidence of a Novel Binding Mode, Med. Chem. Commun, vol.4, pp.1099-1104, 2013. ,
Seleczvely Targezng Prostate Cancer with Antiandrogen Equipped Histone Deacetylase Inhibitors, ACS Chem Biol, vol.8, pp.2550-2560, 2013. ,
Alpha-Heteroatom Derivatised Analogues of FR900098 as Antimalarials, J. Med. Chem, vol.56, pp.376-380, 2013. ,
Cis-Trans Isomerism in Monoalkylhydroxamic Acids by 1 H, 13 C and 15 N NMR Spectroscopy, Magn. Reson. Chem, vol.26, pp.970-973, 1988. ,
Conformational Behaviour of Hydroxamic Acids : Ab Initio and Structural Studies, J. Chem. Soc. Perkin Trans, vol.2, pp.2673-2679, 1996. ,
1 H and 13 C NMR Studies of Isomerism in Hydroxamic Acids, Magn. Reson. Chem, vol.29, pp.40-45, 1991. ,
Conformational Behavior of Some Hydroxamic Acids, Org. Biomol. Chem, vol.1, issue.12, pp.2200-2206, 2003. ,
Structural Metrics Relationships in Covalently Bonded Organic Azides. Acta Crystal, vol.55, pp.807-809, 1999. ,
Isoprenoid Biosynthesis as a Target for Antibacterial and Antiparasitic Drugs: Phosphonohydroxamic Acids as Inhibitors of Deoxyxylulose Phosphate Reducto-Isomerase ,
, Biochem. J, vol.386, pp.127-135, 2005.
Alkylation of N-Benzyloxyureas and Carbamates, Tetrahedron Lett, vol.30, pp.31-34, 1989. ,
, Chem. Ber, vol.94, pp.3260-3275, 1961.
Many-Membered Carbon Rings. VII. Cyclooctyne, J. Am. Chem. Soc, vol.75, pp.2153-2154, 1953. ,
Second-Generation Difluorinated Cyclooctynes for Copper-Free Click Chemistry, J. Am. Chem. Soc, vol.130, pp.11486-11493, 2008. ,
Bioorthogonal Click Chemistry: Covalent Labeling in Living Systems, QSAR Comb. Sci, vol.26, pp.1211-1219, 2007. ,
A Simple Model for Substituent Effects in Cycloaddition Reactions. I. 1,3-Dipolar Cycloadditions, Tetrahedron Lett, vol.12, pp.2717-2720, 1971. ,
Substituent Effects in 1, 3-Dipolar Cycloadditions of Phenyl Azide, Angew. Chem. Int. Ed, vol.I, pp.838-840, 1972. ,
The Frontier Molecular Orbital Theory of Cycloaddition Reactions, Acc. Chem. Res, vol.8, p.361, 1975. ,
Transition States of Strain-Promoted Cycloadditions of Phenyl Azide and Cyclooctynes, Org. Biomol. Chem, vol.10, pp.1633-1636, 2008. ,
, Sletten, E. M. Compositions and Methods for Modification of Biomolecules, 2016.
Chemical Synthesis , Biological Evaluation and Structure -Activity Relationship Analysis of Azaisoindolinones , a Novel Class of Direct Enoyl-ACP Reductase Inhibitors as Potential Antimycobacterial Agents, Bioorg. Med. Chem, vol.19, pp.6225-6232, 2011. ,
Synthesis of 5-(7-Hydroxyhept-3-Enyl)-1,2-Dithiolan-3-One 1-Oxide, a Core Functionality of Antibiotic Leinamycin, Tetrahedron, vol.59, pp.833-839, 2003. ,
Regio-and Stereochemical Studies on the Nitroso-Diels-Alder Reaction with 1,2-Disubstituted Dienes, Chem. Eur. J, vol.19, pp.15604-15614, 2013. ,
, Stereoselective Intramolecular Haloamidation of N-Protected 3-Hydroxy-4-Pentenylamines and 4-Hydroxy-5-Hexenylamines
, like Protein-Capture Agents, Angew. Chem. Int. Ed, vol.53, pp.4944-4948, 1988.
Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for akt1, J. Am. Chem. Soc, vol.133, issue.45, pp.18280-18288, 2011. ,
Optimising in Situ Click Chemistry: The Screening and Identification of Biotin Protein Ligase Inhibitors, Chem. Sci, vol.2013, issue.9, p.3533 ,
Rational Design of a Fluorescent NADPH Derivative Imaging Constitutive Nitric-Oxide Synthases upon Two-Photon Excitation, Proc. Natl. Acad. Sci, vol.109, pp.12526-12531, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-00748999
Rapid Assembly of Matrix Metalloprotease Inhibitors Using Click Chemistry, Org. Lett, vol.8, issue.17, pp.3821-3824, 2006. ,
Design of Phosphonate Analogs of Short Peptides by "click, Chemistry. Russ. Chem. Bull, vol.64, issue.9, pp.2172-2177, 2015. ,
Catechol -Rhodanine Derivatives : Specific and Promiscuous Inhibitors of Escherichia Coli Deoxyxylulose Phosphate Reductoisomerase ( DXR ), Bioorg. Med. Chem, vol.22, pp.3713-3719, 2014. ,
Flavonoids: True or Promiscuous Inhibitors of Enzyme? The Case of Deoxyxylulose Phosphate Reductoisomerase, Bioorg. Chem, vol.59, pp.140-144, 2015. ,
, , vol.2, p.3
Growth Inhibition of Mycobacterium smegmatis by Prodrugs of Deoxyxylulose Phosphate Reducto-Isomerase Inhibitors, Promising Anti-Mycobacterial Agents, Eur. J. Med. Chem, vol.51, pp.277-285, 2012. ,
Biosynthesis as a Target for Antibacterial and Antiparasitic Drugs: Phosphonohydroxamic Acids as Inhibitors of Deoxyxylulose Phosphate Reducto-Isomerase, Biochem. J, vol.386, pp.127-135, 2005. ,
A rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding, Anal, Biochem, vol.75, pp.248-254, 1976. ,