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Développement d'une thérapie matricielle associée ou non à une thérapie cellulaire pour le traitement des dommages cérébraux et les déficits fonctionnels après une ischémie cérébrale chez le rat

Abstract : Stroke is the leading cause worldwide of adult severe disability. The limited available treatments for ischemic stroke, which accounts for 87% of strokes, makes it necessary to develop new therapeutical approaches. Stroke is a complex pathology and chronic hypertension (CAH) represents the first aggravating risk factor for ischemic stroke. At the present time, the only two available treatments for ischemic stroke, thrombolysis and thrombectomy, present several side effects limiting their clinical use. Here we evaluate the effect of a molecular RGTA (ReGeneraTing Agent) based therapy combined or not to a cellular therapy based on the use of mesenchymal stem cells (MSCs) for the treatment of ischemic stroke in normo- and hyper-tensive rats. The results demonstrate that the evaluated therapies confer a long lasting neuroprotection accompanied by animals’ functional recovery. Further analysis suggest that RGTA enhances brain plasticity (angiogenesis, and neurogenesis), protects the extracellular matrix structure, and potentiates MSCs’ beneficial effects. In conclusion, our studies demonstrate the efficacy of a molecular and cellular combined therapy conferring a persistent neuroprotection and functional recovery for the treatment of ischemic stroke.
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Submitted on : Friday, September 18, 2020 - 11:49:12 AM
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  • HAL Id : tel-02942782, version 1

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Yacine Khelif. Développement d'une thérapie matricielle associée ou non à une thérapie cellulaire pour le traitement des dommages cérébraux et les déficits fonctionnels après une ischémie cérébrale chez le rat. Médecine humaine et pathologie. Normandie Université, 2018. Français. ⟨NNT : 2018NORMC416⟩. ⟨tel-02942782⟩

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