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, .' @t· OE)il<:*..mttat km~ found t-n thü bio:ro, t~y BBfJI((I and lbe witd ryp.0 wew. ûtnllJt und11:t büth gtü'lï<tb ('Ondittvns

, Sks we~ pKb.:tNy doe to til$ low l.>nrstion r~n.J uoed. in tb~ t<iomEJCK)ts in '-~<i'"l' ro limir hquid l'xttaoiun t'Y k'-'aaü~, Thh ti!su1red in k1Wii2t t-"«Y;eu ua-nsf?t c~Jmpated w th?t in <h? ""'11-a;itat<Xl !bots >nil th Q; in a wduc.d ruk of p:rr>ducf.ion uf llpop:Jpüdes ~il.lo.Ji' illE? syntbe:.:.i~ .;,f tbef, >2 rnc4e-cuilè:S if. .r~~.:ftitfw:.ty illftilmKed b'\1, pp.1-8

, This Wllt iollo""'d ey a o< lltmluati-tü ~lot<ft durfng dte-OO(Otld g,rctMb pba~ :rolamd tü ru& éüU·· :5-tJOEf'lk?n cdrhese a(·Msaad t'Y J ;s;light alMHnL":atli..m doi< rot'he u~ vf ~!umrok:' J.ciJ ffi a c;lil:.h' th>t BBGJOQ nad a physiok'\\iOEl t,--bavk..,r ~imilat f(, tha t of tf-x< vrl:ld tj'f* Analysi> cd li[''P"I''id? pr>:.;iu<liou dutim~ tbe fim B b o! ,g::ttYwrh in tbi> -biüoe-anüt r-i'Vi'!aled Barly ~mtb, Juring th!(:o 72 h .;:::d grt-:AA1h tn th~ f61'fllOOlO:f'S V.'fi:ro a lw wuy 'bimitar-fur rbt? rwn ar-ain~. Typka1ty. a.;·~ifioubn of rte ü1i!Jiut1.1 W'.aB .:t.oorred durlng tbe +:arly e

. Wj!t&quot;t!-tw, DOEpit~ a ~1:!11ihu IJIJ)fll~ lewJ, nryDJ~Ubillin pK-ducrtc-u tyy tbe wikl l'ffM wm; not ob%'1\-"tl-IJ dudag the; fi-oet 8 'h~ as 12' Zf-ro?U:<0d ~S-iu, ~ the SflUll&.sb of rucb compou ndi. ir. knnwn to OC{..ùf on !y a1 l.ht~ OOgin11 ing nf rhe >t<ttior:my fÎ'""' ~ MattiX-â$ÎS:eJ ta:wt d~~-:.tptJOn Wt1t.mt:btl-t Îtnf.' of ftigbt Olfi. ~'llj{'lfttffiBtfy ;:Jfi.1l:f~lli of ~~\Jf?ptJj~ BlttOCU. albw

_. Lli@tt-~pe&lt;-;-f-\\, Ï\'!2? ro diroa~ d.:<'.>'01opaH2nL Hüw-veL ia:<Ku1atk:t1 wi1h thé 1ipo~septide·O'l~tptt)dudu% dcliva-[ive priot to rtaming (.Qd 1:0 i't.lh~lJJCt>-d Hirliing e1Ue~~nc~ tb a! wm; t:xrnàswoi:Jy c:b~tvOO îo font lod?pe ndem 21l:J?0rlnwntt, tra ·~~r bpop1~ptid<m:. pr~>il.l~ lry !1. tûht.IM·ATCC ti6SJ tA) <Utd BBl-:il(il(~ lB?-pmhosys1001 w wmparo rh<' at"l i<y of Ynlct-cype main Arec th33 wltb tbiU iA BB(ll!)J fot t.:d»~Îr:tg S>bi'dli1\~ tnfoc1hm. As ~bown i11 Tabl~t 5, poettüllffil.?.'tlH cd H)Wlatf-.) ~ttd5 wltb Vi>g&tatW~ -cdh: nf rt:w witd-~ ~tra1n fail!J--d m b illt> any pror<t>ttiYW> ~ffec{ but appt.:<:JJ~·oo tD bv .:orrl'!K'

, 11:nd ~ BBiJ 1')) et.·w:.rpctOOuôn.g 00-r.~tft;·e, J

, Mft'.:~S>~M.illn c"1%

. My&lt;, oot!b-.tilin CH M'yc«>uhtdî.n Cll' liK~&S to, p.10575

. Atcc-m, As my<:<?rubtitin disrla:f' arong ardîfi.mg,tJ ?lC liviry ffi vir.ro agaimn P &pkàflidtttm,@tf.~Nro, ir. Ùl ot~·J:)U~ mat tfiB L~~îot!l-bigh.Bt tate of 1-nvitrü ptfdUt:tk-.n of this c<::<1lf'O<md is in'Kilv?<l in th? ptJ:?t.octive 'II,.;r devdop?ld in vivo by tb? moo i:llOO srain. Ea t.ty and lli_llbw proouuion ohtw lff,.)P-(tf(:kl~:s pK~t.ahly enb.w.:e~ LM bki<, ~k-ai P).ffu(:r llf lt.tù s:rJ:hl by· iuht18diaw-ty f('dllcHlg p-:liun p-atllo.gea gp:: .. Pt:h. Tht oote pl~d by th.;:~ m{::-.t

. S$i, YV<2<l1 d iSi'af~ suppr'*'si:..n du>t to lndw:--tion ~il v.:,;;ù;t-:ulK-e i11 tbt-tw,st plam try l:'drt~:.>ti.:t Ho1o\l?'v-er, notw ?.:<f th~ ;;u~tn~ h-ld à pn:-te:ltvf.' o&.lfu-(t unôu th~· -tond tuoos, &bcM>·1ng tha[ tll2"y .:k::. O.Jl tta>;;'l!' any pt1nt t'i'si~tatx:~-indtKtfi% dtth-lry, tye:OEubtll·lfl ("'i"&tp-oc:ducu. Tbli' sl:ze ood K-bU$iU1?f.OE of p1illlts tOEXltbud with the modlfkl<i ;~:r3111 Wfro great et t.llan !l:>t siw and tot>u>r-ll>t:M of d.S::~a.m {()fHKd!i< Jtild ~,~ w:rt si n::dlm w rh~ siz~ and -rot-JJMMSCS of tunreatOO control!> wbt~n they w~ g::n:)Wfl Îfl a sotl nüt

. !k-dfeas-Ç?h, Il"<'' ol sup?ro<~taots fra11 B. su/J!li.is ATCC 6633 &.nd BBG!((I rowa.IBd thé pmo<ot? of 1WT? main roül.e<-uJ at k'Efl~ .:omspct3dj ng w d:IB boru.olc~~,}Ui<-ut~ü:.:~Subti-1i fU> witil C 1 "' or ( 17 fatty .add c-h:ü~ Th~ b:)mdhJ.guts :!.te' ·~onSdeM w t~· moru biol-fJ,f:kT:!.tly a?~t ~·e tb au tM iruri1l5, whkh hJV.!) oootwt h;>ltoea!IJDD ?kt~ d:min; 1:C,. and C ,.) (Il) llha:i~~en s.l:l:~·n ffi a( fungikJA.kicy îna~~wh:b tb~ llUfnbvr of cath:-i1 .en),~ ln tf)? futty &cid chain, wi1d·type 'tt?w ATCC tt6J3 dld nQ 118\~e arry Pf(~roelfve e:iiee1 nn WffiâJù ~dl ingl\ Siltprisioglv. <ttaill ATCC 663J ?w,n ?PP'l?rod w be

, OWt1 by tb~ jJoülati-ry of ltl~ ill 'rÜw a11~.:agoniMK at~tfvjry Df BB(iJùO Jild rt:l2 ln t;!rro ~ota~oot?:tk a-edv-1~1 of orller R.u-iN~ts &traim

, Sunorutrs ni iruri11 i.e l.':ütupou nds witb ~:obott~r fan:y .:tcid .:bain~ (16~ 35:t TM "'etpioilunklll of J1llfec-,.ubtilin by tl~< B001(1) detir?-tWBwag ~ü.so .u:compM.1t&-dbyqu>1Ht:at.Wecha:nge~ în r.he partem üîllfûf:"*Ptid~s. lnroteHJogly. à ~jgnaLtt m/.1 1137.7 was o:karty <nlhl~ù<>J. TliB ;mHspooding o::mpJ<~nd is p<cl:>ably .rructiltally f.imiht tl) iwtins SÎflfB lis J.Pt-~aran

, _'>f rll-2> (l@W ptü

, Thu~ ü't(<t~ expro$tklü of hKillomycm t.~fntbo:rt~ l$ Cl::i"ri:iusty not in-voh·t!d. Tll.6: signal t.'fJUJd th os be f.ltttibur0d te .l rtK'difieij myro:tübt:tHn wllh efthé:t l)c C 1~ fauy, it a peptf:î.:: mOOry coma:tfling a Thr ioskad of a S~t. In botb o~e$., thf. mdRG!le OOf!ftlS"RU a n?w fmrn of mytOEubiilin.lndoed, ruch a. :bo.g farry add rha1n -w~s ne\'i<r tnK(?Um('re.d in ltü:tiü-liki:· 11~plld~s., iil:Od aU:Uflf

, ~ nuîn.s aNl' w acüv-;;nw di:ff0t'(q1 r an:ti llO J..:·ld h'!Sidtli{S Wltb sitnilat sil2 chaJoe (18). Simi1ut1y, tb$ mycot>?ctin symheww contatns ~m idvnytatk'fl doma:in that may Mttt,~i1:0 hn_h tooritw and I-tnoecuin~ (6), en oem(t'fttJated wirh irutin defivat:ivf's . . Hc#irB\'tit. r.llt> IJst ph~flVOl?il~:.71 -ma~ t.X:-a:ur~ as :t'!1JWU in tb~ (..rJSE' o! t:.be no.nribt.)-n:naJ :iudactill ~~ntbet~ ·wlli~:h }X:1W<~%'t:s aJenytalkt.o di

&. Thb and . Ori, re--;t<iv~ ftna:ncUl ~Ypfi«1 (rom. ~ ·vu~t;-~uité &~ &i~ en.;~ '!!'i T~hoob~mo d~ l.Jlk~ trn-Rkskm N.mi-l\, ~S> ·.:lt-Ci:!li1:h., ùw

, Pond~ Eur~n p::nn le ~dtf!p(!:mt:<l'tl 00 kt R~:lwr{'bf!', and the Nm:kln..1l Furu% f?i' &in

?. K. Alpfi, «. Wjuh~, and . U-p!qlm,

M. ,

L. Blfbmoakl, .. T. Iülibr, &. Stinjid~u, and K. Ii, urt~tw:Dt 1%5. ~btU~n A, .a -oc?· <utl1ml: p<>ptk~

J. , &. Jt, and . .-n-wt~, W:iltf"tl~·. t·XJ;. Euo:t.o.:oria rvr t4(lbgl

$. Mm,

R. J\-il, Flill. mHi j. ~t. \l'f!H.:'(I. :li011. BJ..:.:~ollll't.'i or i.\~c-ilt'·, p.1

!. Jab&lt; and . Mi,

~. Lnrf-;--jarti, Wi~ Ntoll ~ ~~Vûüf; ~~a" ts hdllsae:ù try l:lbiJm h..Tma:tltm wrl s;wtoctln pl\, docthm. Vbm f!~o.d, l34:.~H-JJ')

P. .. :&apos;î.-lmbdfll and . S. Id, K.f:IIS!1-I'}Jj'_.)V.\-.jl$:~-UW0-~1 bblt:igic

, Mkt'OOhll Bl?~toclnoL 19:11l,t...l i'l. iO. n~llk r~. L. 1. R~vcl. Juil A. f~M'IlUiltt 1(.0.1 Ptl!drstl-;:-. Hrll.l.urettasoo: IOOdt>l?;.f.am!fl!~hl r-oo, mmro r:t"00Ut.1. rnr mpp~i:lo f:i"f v.:tl-Wr·fl:.'! p.lim pat~oes o.f ?::?

!. Jillb and . L~-»&gt;:!t:-i&apos;fblil)n-di, 21 1~:2,._, .. coocy. w. M .. n. mt.uttnn. D. lL t..tM "'rtd :r. ZUbbr. lÇ-"~. Ait~~ mf erpNWblln!A'n:-&ks~$ ff, vol.7

, JK d~P:t:-p('-rmca:<.o:' aoc tbc O::mc;v.: ~N""m Qf &tm:ôitJJbr ?XliDpYUOElli, J. Jna.~f

!. J. Mycost&apos;iitllln-0\&apos;erprüductiün-ln and . Jvjffjus, J R &toul&. j. J,. m)j P.A. ~~, vol.5

;. !!;-rt-llwitl&apos;uiif-bit, E. Mby, and . Pf, 00 f('rmlO'()I.··:(9ïflmt>. '<,'<;,i, t:l. HUIWDil f'l'(~ ltr

. ~&gt;~&apos;.&apos;! and . &apos;;-ar&apos;c-m, Sô'tUftN·. r. P4:m:Mn:U_ M. Sdtmldl. cv lrk'-, 'f. 56.-.ln. :t'. .I..oe"OEitrn. ~oo ,J. ·vmn. hl<':tc~. Th::: illf':(GJbtiJln qn::b!'moe or !ik'MM '$

. Iq-b~b, l1ftB.J. ütiJ I:.Y.:-4.tbtt. 1':-#~ .. fl'!.:il.:'ollrd M~il00mr.-plil111 fmhc'" ll.!':IU

, tL Hb*:t, c 1W6c Pb.D.l~h unr~ooy o!lk.~, u~e, Mghm

&. Hht and . J~, \L S. lmrmM. K lVxdtm_ ruui :r·. Ca-ull:lk.. 1 OOJ. lille alfocn =e!::a~~

. !!~~~~~t~=«~e~al~~rm-tn-toe-mtn~~re,

». , lf. s., in-4 ~. (u*ff:&.ry. J~L A mp» tdurç man tu! wr rb!.' p~ amü

, Hla_pHP}Olws:::uuXt-Plltill. N., Il

, ~b;::mtie tl :J ::il.ug~ ~-~~a~ in thto &dt, BiWI'i:!tmena.l l:»nùtiau l1f(<l !mres..~rl.ptic-ff ?A lb.:: ~~1ituw ~um (1[ F.v~ <:~;h?.id ~~~;. 1. BH't~f~. l'T4?007--ThUit 15. lmp;. M._ K. &jli1ü a1.:t 1. 1aw.b~ t?:k.f::O. A 11\'\

J. Ot~ujd, Ofithni:rn:litHl ,;:;f ttwuJf, WJt Upv~vuoe pro. ~~~a!:i:t!'::f~~~!~~1~W ~ ~ockett~&Jnrnn ~sn-Af'r~·

, Prnoloe:. f. lint«. trtd JL ~mu. ~l'(l;... ~1rucwrnl md filrt:liüml cb, tm::t.:-rî.:m:tivfi d IK ~ .. -b:l·~~ OKB 1 r.e. 1. Cbllo·ld ln:e.rnt?:t< Sci

W. K. L&lt;t, W. L. Dtff, . A. Rapp, and . Li, J:ra, ~;~&d C . .fUR$ !'#;.). RhttoctCiJ! A, an amlfnngal ~a<Jfl(Jfl!l-o?·~~p.kt.-c d ffoe:t."l~ ,"f<Yb

. H\-i,

. ~&apos;\in, &. Ubhni, and . Rl\,

;. Pfl and F. !!odnli, t;'?:::'iJ':L.S·H. ~ a lM

T. H. Stt&gt;k, . J. Jlla, !. Fnmkl, and ~. J. Vam, lî,li)>.). llapilf ~r~ orJJu:'iid.o, flW:fJ toej~bolltc;wine nunü: :l~j;Ué l~f.t~j'îtiofil(lrltmlilln ~ ~px1mroeUJ M trm.a oelk IW:fJ~ C001mm. r..:b~ Spocm

.. Ltlkn, .. S. C-u.lj.-k-cbldbum, and .. Wtumn, Appt axtefl(ll, rp:i(!ll. ;;m.d A. Baro<rur. 1.995. ~!IHmi: ptx:>dü:1lun and bko-:mud il.::li'1ty ~· ?hl:illi~ hi't'M'>; C1,~7 Hld AKJ.'M ~~' Cl.-45. 1, vol.4, p.11

H. Oi&apos;j:sf and &. F. , 0~, K jf:iUfl:bn. T, S:.:lili-udty, 1 {. Jllt1:hl J.IM~ aDd P

. Tiiiui and . Tij:..-j&apos;i,

$. Dan, F-:o;q.~~ f~tlrw,;q è. ?$iÇ-.:f,u:OO, <to1UI :i!~~it~~~:~~1~~0C:1n:!'rx~~7:~~ r:t!a~nk &.Jwk,mc< n Pail<. s. n~ A. ctot~tb~rm. ood J. x. Ba~ J~R Moet!fi.:a oo >tOC: clum.:u::limr~:c l):ftbe nru.:mrul am tmr~r::ncr~t1tti'W rM. ~m!toe d:lenit.ul ;wd bic

-. P. 1&amp;-piui and . Iirailf!l_,

S. , D. Pimlt, &. L. Aklll, and P. D«ln.-l-!\~, ft:I:Bil-1-ibi~ !mlf, Mu~. 1~"1$. B

I. Ull~fi~ and . Uoyhllllhin!o, -l' pt"illdlt ~!bf');{s proJu:.:>!ct

. Tci,

~. Pltwiv-l-g-..-~-sb, ~ a. .m1 li Kllbi'U.. 1?.»)_ SUfPfOOI\"'<è! ~focs d !bi:Jtoe:s ~.ëx>1r .uK: 1h pr<X.OC~ ?)fi fb~lr4f.!ni:: nl.cnmrwrntJm. J. r~rnrB

, Iit'i;ooos.~l<

&. W. Lila:uparb.-c.-s.-..-:mrt, J. , and W. Kuppctr,

, M.lllrure5 o)f t1illl g~~Wih

, 41:ng ftlîJX1l"OEI~JI1l elfHilO~ b.li:!?::tgbl ~oo1rct ~r mulllpk' a~rumts>~r pa1ù1~r.'m. Rqtopath(îby~ll5:?.-llri4

. ~1 and . Sambrooi, JHnuL .zon Mt~h:ulolr dotliltj: ~ J~f:!,:omi>Jf} muaul. Jl'd cd. Cdd Splif% Hutor.Llt:Pruory. C(Jid ~f'~S Hafbtir. 1'-Vf

, itM!n.. ).-l J):t.!. lloi.>:l.c:f'liJI a:t~tml tl phm d&~~~-J. &\:t(l. fUiR-lW. :e&: :01>-5, p.1

!. Ji, . Cltifj, and . Al,

!. &lt;j and . T. Swi:u,

S. O. Ttdw~ and . Slrnli, f:otln:. ID'\4. l'\Ul.Hft'...d!l j:t'(~ duo:liùlil"t11WOSirif,\lS/iAM'il;;ub::iX~I>.-~;afli1'itliiUlt, e<:it1b~::.~.:tnlc.r. At-'"fll. Eti.rtroa. Ml..:rt:obl?:<l. 'tl::l:M-?)

. A. Eu!-&apos;&gt;w and . __-~m, , vol.4

. Thrlloet and . Th}, Sct:re1bn. l~i:mtlmt. ai'"IJ! iill:lluaerttl OO:Mif

J. Jrci/!&apos;&apos;ii, !. S. , and L. , Jf&-~ :'f!OW~Iiirt<d pr:m~iL 1. fWlf.<l'kt Jail:l«A~hi

~. Y. ~t-ol!f.iw.-j&apos;.-}jquu and P. Tmiuiirt, lü !!fi..%ili!. Gti. 1 IJI the rcèltcth!n of ~rey lOOU!d Ill'~ OE~l.1 ty PtKf'if~ r:b.~ .;.n llfJF4r:·. J. _Afi::t. Mi::-1\."ti\il. ~: IJ51--1Jhi'J ?<6. =rà~~tm~u:!~tu~~ Â~p;~:i ~~1 it:~~"ll:~~:i~:ms-lntt J:. \\o'l:ljlll. J. M. 2"~{11 Mt:rubb! lmt-r

S. ~-&apos;f~ubll&apos;b, T. S.-furntboo, and T. ,

K. I. Uuiii(ti!j and . Ft,

, Arnirnk:ro!Jbl ~IMI~' <tf ~u/rure illtmtt: M Jk..citl'gx M~L"<~u~<:ib.:. RG~ Mlitk::!l fr,;.m fflllt.f.:.rcy k~~·~-PhJ'IVp.llh?)bgy lrll, p.8

~. , C. Y. , and J. W. ,

!. Prv and . Oci!(rll-o, f t11H'ki A l:ty &~i:;~~ .:J.l'lil;;~::t'ti$,oi)'ir.i&d %tffi~ll, §.R-00iX':t~M ::.~:t~\l. Sdl Il.h>l. ~ocbém. M:)::>;:'L?eJ

R. L. L-m-mupwa and .. B. , om:tt. 11. 1i1jtm, u al. 1'47. OEll.:~n iiflr.l i:ltyC!Jlj;=jilln: IH~d btt?.aé ~'o;trum am1tocoefiàl .lDiibkd, IJ:ilûll, la:«.~·~lrfJ ..tllit otmi-McJe-rtal <rll'iÙ, p.7

P. ?. Tnl-;-r, . Nw!iti-;-f!?-, and . Pq, amit<lotk:$, p. wn~~ 16. h A. L &'.flWf!.tk:in. J. A. tfudl, 'if!\!' R. ~li:k ~~ 1, ~"ti"J/ll(.~ J1tP.·{~ .md ull~r.gnrn-pom'tt, o:X<ftid.trlt?Jf tll2' line~n nK.~lofhiamwstooü:m traJ:i-on in ~ fc\

.. Prr~-..;l-ovcrflc, ing: >'Xf'?~IIH>Iially fed-bntdi culture rO-EFBC'J. 31nce (be pro-ce~s c:.p-eratoo wi!.:h .J tt)Imlntù Yc~lutni', ir. fouJd 00 relnteJ to-o::mtinucus cu.liJ.tro?s., E'Or tb~ .culture--s~ the hiomass Gc:ooeutrm:ion in e, bi~s S:.(JDC1?'otratkn in th~-biorea.tb.)I. i\n.:.d y.sis of b~::::.ma.ss conrentration Jll tbe forun coll<>c

, Ouly a part ofthe biomass is extr.a;:tedfrom th..;-fo-anl foJJowinga lineill' r?la lionship. Wlllt!ewer th<' nl!k<lion

, -e-i);mr, fÜr~~ thê b:Jn-:n& h 1o-wttr tltao u., Lltt<!'f. th? 0-EFBC' l>eo?fits fh'm tho oJvam?ge of tlli' i n.zri'a.te-,_)f tbë bic-.rnliSJ canaetltratiùn Ln the bkrea.ctX)t", This pro-(&\SCOU!d!Je tlluswn!ik'k!re, cflcli?mration ln fon m a.nd iu bloe

\. &lt;&lt;iv, A dynornicalmodd is neMèd k? :<imulaiB !l'ft emlutirn of tlli' 'l"f'Ci:fic @''"w!h FM dur ing !lw ~><p.,tim.mrs. ~-~tton :2 of th~ ankJe J.'?fCJYidtts. th~ dB'St.::-r~ption ?Jf li\Y..pl>ri-mi'ntid ((\fi-dltions ;mdofJ.:ltJ (.?::dloc-tlon, se...~tkzrd addoe.s.ws. tt~ mo4oll1ng fr~rrewc:rt Jlld th<>x~tki!l """"''cl> !br id?mifkaticn iJf the P,.îfdflli'k'rs s)f thot mcrdd, \V.hilto the-()ptim:i~itth>n stJ:aOOgy 239 îs giv~n in Section ·L SKtion 5 Pf'?,)vid~s a discOENion of eA-peximenilll r<!sults anJ üf ih<' d;.>ign of the m<xlil It <':thibits th<' f~Jatit..'t1th1p tdWOOtl Ehe Jnt-ij.Il Sf~·cific ,g.TüWtb I'..'t(?-S esti.nt.lted t<y tb<~ modcll!lld tho rny<"O<ut<ilin ~>r>:<:iuulvity 2. L &Je! erna! srraù!. arA.1 g-.r~Ytt'ût .;:o'lkfùlo-tw in jfask aJ!-d bioreci'C &u The ~train BBGHO, bromnss rec)'>cling. th~ :s-r~ific gtowth r;;.te hl no m'Jrli' c'.:neta.nt e-w:o with. ~-:xr.oo.al ti~l food llüw nue

B. Swrfli, Aer ùf d1e my--.:x\M:tbtilin ::;j11th~ cperco by a rromc?Lii"r c-cl_g:inat-1ng from the rep!ka.tkYJ gene repU ()f :Jîapkvlact"K:UJS ~ti!rt'fH koo:pful of cdhs .;:on~rvl3d Jt --&J ~c in a rt.._;t n1êJJum. 1)-Attl.iniug 4JY-~-gly,;:-erùL CdJs u-w:·e @'OVtTI nt 14(}rpm and. 30-:--{, ATO:' 6633 by repla!~ent ~:.·f (00 n.:ltive pn::-m~, p.1

. J~ii-urn-illt, JS f,:-Uows: ghJ(\:t

, ya1~t extr

&. Kzhf, 4,1.QgL -1 cMgSO~.(· 5 g L-1 .KCU!, pp.5-6

L. , Lê mg L -l :MrtS04. 0.4rngL -l A 5-L Bbflow 3<}01) bJorei.Klcr iN<m>-Bnmswick, NJ, USA) WJW lnücula!i'd with mld-k>gdtithmk grown t~ll>

J. Litera, lbe pll w;w <?mtroll<'d m the ViJlue of 65 wifb Jdding Kf)-H Dr H.~S(lt s.oh1tion.s._ Tem-{X"fllhlnè was ?ontn-:aliM at Jü ''C. Tbe a-era.tioo raw wJs fixed ar 0,25 Y\-11!-i and the dis:solved oX}·gen o:::toeC:<nt.ratkn "'!tB O.)fr trôU.oct .ctbü~ 1(1-q:.. of thé ~aturatlon C'!)noentraü~)n tha.n.ks co tbè adaptiw stlrrer 'l""'d ranging from Xü t1 ~>:<:?rpm. Th& f?ed medium

, to e--tb--Ltre thi" stü-rit~g a~j the ?>:xygen ""'"'fere Th<! UPJ.';<l' ünt""ll;,r Wib unusually ilxoo JUst abYre tlm initial hetght or the hquid hrnb, ifi<. way Thot k.t'W"& on?" w~ Îltll1Ë"rse-d în tbe l"Tc)t.b_ M it :Ï$ doue c lamic:.ally in a cuh!l.:W" ~:-~oees...s

, The cbviüm dl'oot of tbb k~.:ùed surf oK'<' impdler wos tv jncr-Ent~~ dnwticalty the {r;~uuiug ''~lty at tb2 gas hquld Jmerf;y:J?, The '-:)ff-ga, Aîog d-e-vices Wi2:tiB {J'Ii~Iztd ln order to gpt a, pp.3-4

. Usi&quot;d-f-t, tr tünuolling (he pnx~~ ,lnd acquirllJ_g druu wmg AFS Fiowmman:l iNé'W· Bnmsvdck. NJ. liSA)

, I1k~ <":A't:?fl'O-t>-·i~g e.'l.'f.>O!!eJ<t~i:.:tlfi!d~bct

-. Titi&apos;-tdirnn-s-;-p, ntil the oHlin t:.;trb)n ~Kt..uce wus: depJet0d. Il is to [l(dC:.E< that -EhB Ie-:cnruu1plion of Clfg;.tnic o.dd by-products liLJ2 ncot?tatf: wn:s o~wd. ln pha;,e f. the ·,x:olurne V ?>f cr?:-lh ill Ill~ biCUJlKK?r docr&'lsro t:.ox.lllW of Ille foam overtkrw .1ppe:>rlog in the early str, r>J the vç~Jumc 1l incr~~d {l{'{'Qrding (() th.z. exp)-oontially f~OO ftow r<.~te, A~nl.fl WilS alkUl>l.ted X:Cl)tding to tJlt. fùllowing fbnunl? &rived from ülll'bort-limhro EFilC: \li

?. D&gt;-!hé-mithl-bb~ujiss-quantlty-i&apos;))x&lt; and .. , 1997). s., i!nd So tltf:! gJw:.,~ \:'(:tnr:etltmtit>n~ in tht f~d mediurn, 4û g L-l. ;md ln the bh:tie.:x-tor ru: !.toe fuOO bBg.iuning._ ckoe to Otf!L and 1/r is tlw éXp?ttd growth mte tn>:ler tl:>2 "'"umptv m of a p>euoo sbNtdy-i, 10 cakula!Q the fé<Jd moo, UJü HCL, do?e to th~ wlcw of lLIJ gg-1 r

, During phat<% Il an, ?gr.-ivdy wft.cti.t\~ 1he oxygon dmmmd of the j\1\:<Wit\g eells. The k11gths 240 6f lh~?e ph-?

&. Li, Tl}? O:)tuïd:.:'11lt volume \f or:~tatiat çt:;.uJd na W é11surthl for .h.igh f~OO EU<i'S becw.1se .tin OOc-atm bigbe than 1~~:' Etglu 0-EFf!C ~xperimi'-nts cq;rentte:J at ditTerent. feed ra(er> tfr mngine ftomü.f(.S w ü, ! l3llld th" food rat? llr

C. Jud, ~. , and B. , OO fünJn imnpks w-er-o0 c-'>!nttifug, ?ugh Cl/\ M~:<l-Ckan crutridge

. Alltef&apos;b.-i:n!erti&lt;!-id and . Usa!, The duu:gro. oelumn was ,.·aslwd with 8 rnL ofwawr ;mdS mL of n 51:X5<'waror and rn?ilim.;:.l rolutkc. The lipor.,ptidi>t "'"'"' theo elu led witb /\mL of l?)J% nwlh 1111ol (HPLC gmk, ACJos ()rgz~ok s. GooL B"'Jgium). The extrod was t<v:m;;:bt K' dryn~ss oofa:o dls-o.:4ulion in 20) ,.L !'lWthilllol. Tite W!mpl? ls th"n .iu }<>:-ted ;yld analyzod by h.igh-f"rforrnaoeel!quid chr-omalographyustnç .<tC1So:Aumn!5 j.UU.,., 25Jmm x 4,6 mm_ 21.s TP. \"YDAC1. The tn}'<cOEub:ilins, p.5

, /vi\:)_ Th-2 llrAA' rate" ww l.mL rnJn-l ,deJ?ctkm w;n<Biength it, 114n~, PurlftN my"'l:~t,.~ubtilint and su:tf~dtm u~J J'!>: standards '"''i"rü from 5~ma. Tht rotmttkn thn~ and &C:4:'Ctld dé"rlv~uiw ùJ ltté ab~otytion ~trum ootwwn 20:1 aoJ 40ümn tDkdo Array l'DA 91ft

. Tm, <ligllt was d>~<Nrminro Jfti'r dryiog 48h at llO ''C J W~$h00 pi<ll<!! .;,;fa IOrnf. ?mnpli'. nw ~·ptiral dE<nsity at OO:J nm

J. Shlnmdzu~ and . Rtpnn, J\n t-'Çtktll démit, p.1

, Wre T1Mpoctivcly üb>ero;ed in the phcoe U i!ndllluf the&p<.ritiWllll~. A ""'ITIIUIIK tT>.xli!l basrocc !:trc?m, Jt<eentrat!on of 0.33 gD. Vi

, Mcfocd's fuu:tion. 'lbr rnas.s baktw::>t" in rbe k..:un -.~oll.i-:(1!-:)r ü< givenby: ln lhi? part. tM mo®l inwlves forn pill\lln.,ooro (?oo Nt?m<>n-.;;.laùJJ'o? fcr the de.finitlonst tirttu~ Ks~ ms znd lX·s r.r?b!tOO tc~ llhysl?:dogjc:al .z-hara..:.t?-ri, f both its parnm"t""' and vanablt·z. ln the rest of the pre?ru~<>li>:>n, üll tM \<'.Jriab:le-~ are fu:nctions: f>f tirnEL Für .t.itnplkjry~ thi-t n:.enti.on 1~ avtd.doË

, Uétl b:) the O:)O.<:entmtioll in bh..:-.re-a.vlct X, HoW(;<'liBL for f.:mlHJve<rtlrriotlng pllXX'&3eiL oo coly J pm:t of blomJ~s is e:xtract~d. tbe: btmn;tw >Jon.centratkm in ~ drJg._ged foam Xoot c:an M .;:oxpr-2'ss.:>d ti}' h Un&îf relation wheru oe aud ft c.oeffidiftlt.l} are rwo t.ldditiüwJl paramett~r8 of tt~ m<Kii<l, 11-üs roloticn a.lk~· & handlîng Iwo main :as6umptk~ns, X .:out is rmportlùlli!l tox (/3 =0) !.hll! oenespond> k?. partial

. Oo?id«rro.-t.-;-r?:..&lt;l-tha?-le and C. Id-toe-?.-;-c?tlim-vl-wbere, 3 Li~ a uXI31-rêllltro te> the very 1ilrutll overftowing ?)i fl;::.um thar r~n1alns in phMü II Thls fonn also guJ.rant~s tho? \\Jlmne \:'ln the bi.t:xe,rtor to be cüll3ttlnt ln rta~ m mrl equal ~J ~riiiD-c POOiltni'ter astimaticn ü)USiz:ts in tînrling a S?.l1 üf <lppfq,Tia.!Jt ''""''" for tho> nK.:lêl pil!illllli)fers using the avoihibl<> experimiln-t~ll data. POEJ,Jm.o?Mr idendfkati~Jnof ncnli.noclfd~mt11.1lknJ mod-é'b ..:.:~n lx-crpphOO to bi.fAo.gk:al ntltur(2: pnxess<GJ.l,>et al. 2005). A ..:h-o~en Ob.ta.J,:tive functi.:tn., ·tttbje.ct tc~ the constr.rri:nts I?!pt~nt~d 241 b;; tl'k' d.y1t;,mk.:,l m.odd h c~ptimi~d a.::cording b:. -l.b;: P'lramto?E. v·JJues. The ct<9~rh-"{' functiau n1:locts th.? di~Tf<P.Jn?,j.?s l:>erwoen dlè BXJRrimenlal d,1ta lUid th.. ou tpuw of th<· mnl<>L lt can bf' ('(J-flSidt!ro?d -ZJj;;. ~1 Jlle;)SUfemE«nt of the quaJity (?f the fitting Op?fJtÜf)D brtwwn th~ ~\J dataSi'ts, oditkm; .km= 0 Lh-1 . ·l'he brüth ""l.)lun1e in bîrt'~a~t<)f. tt. is a functiw uf time aud d<>pends "" tb.. fooding Jkrv;· ral>l fm In pha9& Ill. th:! pn...-<c~BSSüperate:tata<:otlst~nt volt.1nl.t? Th~ré tore. th.. ioam (?Wrllowilw: llDW mlq rn ust oo "'l'Ml b:? th? f"-'d tlüv. ralot Ut,:u lltfa.ds h:.? tfp C(n.Jition_ In croer t

, andO 40h-1 forth? ma:xînml<roeitk !'R""ih.mre,l'orc~wappli cu.tton,. the quad:rntic objocth---e funçüon is ca.kubwd fr()ffi throo .exp~rim~ntal dalawN \Ve c:ho(?te n gr.zrl~nt-l

, Sine# the ;:unoun t ·:Jf bic?ma.oe in the foarn coll~ëCJor ü: mea--surw by th~ dry wclgtlt 1i>êbnique whicb r"quir<-s ? minimum of . . ;;)J.fi"<?çt~d Yl;)h.Imil:'~ tb? blomastCQJK>2'mrcttJo-n. i..u tt~ foamXou: i~ not dir,ctly av:tibbk Un:lar !he a??urnptiml. thw: Xout remaim ..:on~t.tnton a sb, whkh ts ünpkntenWd in bo-1-zttlat~TM tüftwaw by fnün.<:=tHl fun(-tiur.t tü&:..'tl""i? {.üfl3rmin..c-d n·Jnhn2~I optimi-saüon problem_ ln this functiün~ iUI estimale rd' the He~..,j,:Jn (~f the L.Jgmn_v,ian functJ,)n is ur.:!ated ateochironti<:<l. Simulink:? athiewz tl>?·simula!iou proc'èdur-e

. Xo.n:-can-be&gt;:j&apos;sümo,

, h e:s:ümt1t?rl a8 l;l ratio of tbe v&i<lti(:->11 c4 biomasr. qu4lllity <trd tbe w.riatiorc; of vulmoo drning tb>?, tim-e pe.fi..:d bet't*'oen tw.(' rnea'RlfBmtluts. (~) 7J :-.:, ~ c~ ~ fî~ . .3 . .Me;c,ured l:i0mam m roe btüt:.:v->lC~ otOO ln th>:< .;:>')floc lor eflpte~d irt gL··?. wfwt-~Y.:o.i :is thé bît)1011S.S .JüflO>)nttation in Ü't.i> o-:dloctor iJI1d v~

, MtHWih~ quMtl-tiN; tf1 w h<tor~~fi<t" t_ai,l wbJJ dl~ Ùi ~ f<..ôi'IJO roll~wr uo.~ <b;;h~_l. foji' th~ tbrt<<:'! >!:lpt"fiDt~ftl:i ;~ro(t'-d >ltdifu!-r~n: ~dr, Jté& lir-('if-f':',2(1A:t rJf'L Hr--0.071 (k:ft n::fddl<:':-!>lftJ il: -(tO~~(~fi ,J-~n~e~~~~ mh~1

. M~·, J. Uur, and . Ûidm, l\)t>l;; (l,f ';.'(lluU.V. m tb:~ t.ldt'.l<:kt I5,Â! '>ll)bdJ iu ~ tb >:tt <'<l>l:»!f-Ümnh·

, ~rl!ht mt.ddk) <tnJ lh-t).C~{:riprtdo'WR) ~~>:tm h-1 ,Thw-1:Jioet,'<!.t:~ c:-:tktd

, a ;;:ubYJt of perrin~nt pacm1oe~~ t.ba~ cau 00 nzl1.-ably ~stim21t<i'd from rlk avallabl~ Jara hM mt.; ?d;;ctêi As tbf> prc~~~%iii ope.ratt.>S at c~"Jrbon lirmted...grouth at Jo'!.\ gwvr1b n.t~ :;;:m-d :rJ:I;·ünling t0 thê ùtap0 of setu, 2.1)1 !L"" 1 ~rurru.wd ~1tb~-CID65g:Ç 1 b-~t J.nd K~-üü15;g_L~1 . In our f:XJ'X"T.iments~ the snl.lll nLmlOOr of smnpl0& für o?.::,;h txperirn~m m1ght nct aJktw tb.e pr-oper esthmdkm of ali p:wt~m eten of th~ mcool "'hkh Jr< ~

~. Strbset-ks and .. Pn.x--tl.~-for-tontinuous-pn, The tina! ...::.;__vtci!l1lr(ttion of lip:tpé<ptkits in the bk)reoctcf ond in the foam wlk<ètnr 'n givfn in l:?bk J. Roth .. mycosubtillin anJ Stllfaetin "'"'"' fn1nd ?s e'P"':ted but wwluSlvcly in tite fo;,m coll.,.:ted 0Utside Lb@ bit.."'f!eactü.r. 1110 ~iosurJ~Ktaut r.oeo~r)' pN.ren? was thus ab:'-ll 1001(, S-imil.;u-re?,.;::çever:y into r.l"ie ft"'1rn waa-pr~ viou8lydtsuired for surfaotin (Davi? et aL 2001) but 00'\<'<lf for any iturlrtk mrnp)unds, 1tw e.sti.matton of the bi~:Jntal'JS <JAl>:::e"ntrntion in tbe (oJm ü expresSi'd a.s a fun-ction of th~ m~an C(}U.C·OOtnnion "ul tbe b.lorrill, ootnp has!ld nn an 0-EFBC. Thri!i! i':Y.p!'1iment< wer<: f"IT<:.nn<>dat different foo:l rat;:,? !lr

. Villut, ll: of v-indioews th;tl the bion, JI$."S

X. Lot and C. , ow:::e-nir.-rtif.:OE -*myt:Q.~Iiuoodr;urfa.;Jlno:.:qR~-diu ms L"' 1 IR dY b-b_'ft'~

, ~-tor~ ln. th~ W.m .:cl~ fo.r {)

. Efrc-~-!red--jt-&amp;ffie, .amo::ifl«lor Bi«·~·::tn }Ay.;'v:mbtihn Smf...:ua Myo~ubti.Un Sutfu

, rns ofO.l-:! gg-1 b-1 ~thor Y,j,lue I.Jfjlobt:ai.n~dis...zqu.J:l tü 1 70gL _J ,A8-m3 b~'cm>Zs U]Ull ID C>/)65g,!,C 1 b-1 the y;rlt., üf (:1 reaDh"-' 2.ûlgl ~l g?'ttinl!' mom dr, Tt')2: optimis.atl.co strnf.egy r~rmit~ the e:stimation of thi< f<aram?'tenurn<>ll' m~m. Y:'VS A> and{!, Result5 ru:~ gimn in Tahle ::' for beth ms lK,unda.ry v.alu~, \\<'ith

, ,dl)tt.>:J ruprc-·t ;,rrul fccd ut~ J/r ?:Oi,oalrd l'U:r'>"é'~ bt lb~ thr~ c-.qxcnm>t!"nh< o~.1LOO at diffe:r"i!Bifoedmtc.»J!l:·-O,I)fJ.2~gN, lh --(UJ71 (un.ifk)<1nd ür-0.(~6 '~'t(> ~:ropoe-~ in b~1, Th~ Villoe{:) =~

, !i-ü2üsg·?, a-o ;)bdfl-:Hil tL~~ ~inHuJ =iih '·~· -ox~s a:g-1 tt ~l l)nJ K, ~t rtm!ll-û-~3b~1

!. , ). , and P. K. Dod:j&apos;, >Jtye-~re~ m ~ oJ' mymmbtilm8~t h~ l, w.. fuoctL"l~of mem e'JQW<'Û1-nt>! .u--Ji ~·wrew.,.,.rdin.b--1 (riglï). Me-m~t

J. ~. Ùjoct, ioo d r;b;-fc<td rie ~:pre~d ill t.··· ? ~ ~ft

T. T&gt;k·,

, oel fOEôJue t'r» e~ÛlliliNB tf.~. Y~

J. (. and X. The--w,.?;.due, of ?J33h-1 is abo very d.(?Bt': ln tli;,·alu? ê!f ?L'5 h-1 ~nkula!M during pbawl uf the f'lüC

. Ccms, . Equootly, and . Ms, Loo e,;d .? 19'-'7) to 0.46gg 1 (Sou?1'<>1 nL 19\16}. Tb& k>W~<llueof th.;, gm"'1h ykld on gloeoee is synouymous wilh a k?w en>~trgy ~ffiden;:y. In om cJ;;o, lbü pb<>noma:~on oeold oo ~xplmn.d by twe< foctc?rs. Hrut, xetmt.o hM bé&n d, /OJJ65 gg-1 h-l was. rhcmnln tlk' > ~quel of the urtkl? fcr furth~r sinru1atictlfi' Th~ }'":ys V>lh» h ~quai tc1 û 2(! s, g-i wtüdt h sHg.htly lov.<~r tb.;ul ~locted .)(:(o)rding to the bfbliography, ln ça~ a)( 8_ tubtilis @ff.tVif:t.lw oe ,g.lut·ose.. outhors g.ei'J'l<nlly rep::.vt vaJJk.s roogtng fn.:tm 031

, AJtl"' a ms of ü,J~ g.g-· 1 b-1 .;c-ufir.ming~)-wçh.,.·)k.rc?f.;:1fn~ cif0,ù65gg 1 b~l Tl-., eK?lutkn ?:>f ll:re meMuroo volum? in Ute bkceador b <~pr<Metttéd ln Fig. 4 (riglll? ;ut>l fits witb th<> estiJn,;,ted valoes 244 5A. Ct:.")..'~"'"-rtr'latlt.i!J beti.-.r-ee!t t.tuYm spb~(ti' g.'~tYwth mtfün...t prorftinb:;ry Tm gm\'tth mté si mu lotioo is drue and th, 1~ higt.ii'.r in d:Jo@ caoo of roe.uJts ~im u k1t~d witb <l f~ït<llneteu: subtets ?<-.~ti:n:ult

;. Rg, H whut 6:<..11nit>g i? OE:gli,gibk, th!> >r<>-dtîri gn, vol.5

;. !!lm-=-lir.-111&lt;?-brginnlng-e&lt;f-tb, J. :. Am, and C. , iii pllllllê fli in<lih::e> m itta'f!a.s.? of the >lope <?f the p curw. ln Appendix A. Wû demon<>tri!le thal th? limit mue of the 'l"!"':ific g;rov?tb rnte < 1111 be re,;::hOO and b gre<

, tM/ YX)$5m) + ( S,n :' X~111t) -1l/ .fx_>S' J Re--mùts s

. ~!te, #pf'ci.fic gtowtb ratot~~ jf-tr.;>at JI

. J~·er, <A.peri.m<!tlt Tbem:dol wa, extrap:Jli!!oo t.::?Jiv~ Jddltiülll!le"!'oerlm, p.1
URL : https://hal.archives-ouvertes.fr/in2p3-00743070

;. 06~-h-1.-s:imublim»-wcre and V. -. , 4 WE'Ie .:t}S>.) r\.."'1f<::m."floiild iJ.n?j W"Wi! corre la lOO to pv:xlutli,ily. Fig. 6 (kft dd*.' sltow? thal lM meon valu>? of s-pedfi<c gH.·"Nf·th ratB was a l.it1e<1r functic:o vf (hi:!> food rul?. This reoult conùrrn>!ld the mmarl; *, the r>ngê [1.09 g, 1..43 eJ . . Th" SIIf.lli' simulatÎOOB -il.> ÎU Fi

, Thenfom~ the lllit1tirn um mycç.-su btllin :p.rodudJVlty oorresponds to the rna:timurn gwwtb mw. The ?P"""ilk prcdoetivily in 11\Y0Y. mbùlin wa. rnaxim1ll 1\:.r f""':lrale of O.OS6h-1 lt oe3:hed ùtë v{lLU>2 r::~f 1 -~7 mg cl

, Js-tibtilin leJj v~~ J: roc:ovmy pen:.;mtage Jpprmx::btng H)ü~-. FcAunmg ~rflctY~-· al.s-(1 loads b:) the k;s~ of J. blo-rn ats cc(ncentr, Prodt.KtiDU of bkHmrfackmts by aerobic m.kro:.r_g,anhtru 10 bictedotml; is fr~<IU<'ntly limhed by !lw fvatning 0-EF&C b; a DlCf'FJC""' in which tbbywbkm t.?wrn<>s an ad,'dlllii~W bK·> US<' üf tht? high :oe~::;t)very _p5:rc enta.giè:' of lhe bJogurfaa.:::t.ant in tht ü::!('Jm, In uur sttrly. ·tb~ (f.uHnuou~ re1noval cd· the :myr

A. \$llftd, Th:is Iê'Stllt WJf. (t;mfinned tron.1 an original modd th> t f"Crn:irs tlli> haudling eof d-w c""'? <Jft.:.lh exponentiall0d-baoeh 3nd avt'rflowing ''IX'"'mial fed-batüb 1l1e

U. ). Vztl and _. Th, xperitoont:L this NTor roowiood ac<:ept,bk lt sltowtd th<' gc.cù at<illty of tb? mede! lü p-~dk t th? l'"'"'"''; b?ba?ionr a>t dlff<'I~nt food rotes> Basi'd con thü lrn""'kdg~-mnst~nt-food:irtg strat~g.ies ZtUc~vrîng ·the grovAh of the rnktoQl1FtULs:m nt .SLtslJtinabk md (()nf.it.lrrl: s~dbr :;v.)'""i.h r~tlê~ as j t is (kl-lR in :~-xuüal Il2fTdm~ _prvcess ~'-mid ·oe const-OEre=d ff?r furth>Yr ptws-k""~ll)_f(l\'-J.I $ludies requinng ? ?texly-lltaoe> Fmm this mede!. a qum-bnOElf rdati(Jnsltip OOt~wn prüductlvtty and the m~au spe-(;ifi( ~fCt\tlt.h rate obtam~d fro, Thb prc>~Spect oJUld oe rft:rchOO hy go?U.lng .1 mor..:> effic.ient kMruîng using a.n.olh-t?:r t>1:t0 of trnpdler thJJI wou Id hùld up ? corutant vcAmne ofbroth during th0 0-EFBC' > Ho?wwr. th"' pi1.xltwtlvity of L~7 Illfl of myrosubtitin g-l <Jf t.iomJss b-L obtainoo with tbi' hi~t teste<J foed rn tc

, Univêt1!i!é d?s Sdenoe~ et T~ctin:::llüg1t?s de, Lllle~ the k.! gion Nord Piis oe ·, Jprni>nL UUJ At timemstano=fJ.. befurethefEd-t\rt..:.,h~c-w..S::::::c~.., then If=')~ Fer a .steady s.-tate of the :fud-hlKh ~·ulturf3' ff(

, cëwn l' lim = f.,.l'lt: 1/r In til~ fournmg pbJoo nf tb~ p-oc-. frcAfl Eq, 1 3). we bave V~=-~VX+l:S18 -5\fm-fnslFX, ?lt !Jfr-=0 LùDklog f;:)f the ste

, pt1d~; 1!1.nin$ a:d~dm~_.ActP:llY--Uf:ll.(lf.UX': rehtJ>:t.Ehip$ u

!. Jn, M. Y. Toj-c.-;-t.-d, and C. R. D~ltl, S% Cbnt.l1L Murnlfdl:", [1}4_ kttfl>! UWly G.fL 198L ln ~iru mb.:.t.i<ll Ni»n<:eaoto;~il r.tK(?~rv, vol.2, p.1

D. , A. Lfnch, . Hc, . K. V{lr, and .. .. Oc, .'\tr:f d ~urb.r<:tin llr-An

T. .. and ~. , , pp.6-11

. C. G~v, . ~b@&apos;.-e, &. L. Jlao, and . Xiu, hr.ut~t.m id->$rul6aati:.n ptobl~m t>f the· oonli:oe-~r dyr.tm:irnt ~:~tem u

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. A. Roll-l-n~wtl, l~, L 1tQ5. t-boti:oeoc-~em idew:iU ... <Kioo vü .::tire<t ~·~i@.bt '-T"Iirnibltioo, ~rna:k,:J: .oU !)~~ 4, pp.15-490

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