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Pupillométrie dynamique : approches fondamentales et cliniques

Abstract : The first study conducted shows that the modulations of pupil diameter present during visual exploration of the environment, related on the one hand to the heterogeneity of the pupil response as a function of the location on the retina of the light stimulation, and on the other hand to the attentional and cognitive load, have no influence on visual performance during a visual discrimination task of spatial frequencies, despite the effect of pupil size on the optical quality of the eye. However, we show that pupillary dynamics related to cognitive load are a marker of memory encoding. The second chapter presents our clinical study using pupillary dynamics in innovative, objective, simple and rapid tests aimed at detecting deficient visual field locations (Stargardt's disease, pigmentary retinitis, Leber's hereditary optical neuropathy) compared to a group of control subjects; and details preliminary experiments conducted in healthy subjects and patients with optic neuritis to develop two new pupillometric tests with low sensitivity to sympathetic (cognitive) modulation. The first test uses the endogenous oscillation cycle of the pupil and the second the frequency tagging method. While much work needs to be done to democratize these new dynamic pupillometry perimetry methods, our study shows very encouraging results in discriminating patients with pathologies by comparing their pupillary behaviour to that of healthy control subjects.
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  • HAL Id : tel-02935896, version 1

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Suzon Ajasse. Pupillométrie dynamique : approches fondamentales et cliniques. Sciences cognitives. Sorbonne Université, 2019. Français. ⟨NNT : 2019SORUS006⟩. ⟨tel-02935896⟩

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