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Etude de nouvelles architectures de laboratoires sur puces hyperfréquences intégrées sur CMOS pour les applications biomédicales

Abstract : The proposed work presented in this thesis concerns the design and the implementation of an original and innovative architecture of an active RF biosensor dedicated to microwave dielectric spectroscopy. The developed sensor is based on capacitive detection. It is able to detect, analyze and discriminate biological samples, such as cancer cells, suspended in a microfluidic channel, according to their dielectric properties. It is capable of measuring the existing differences between them with a very high sensitivity. A detection system, based on two LC injection locked oscillators (ILOs) operating at a frequency close to 5 GHz and integrated on a silicon substrate using a BiCMOS SiGe: C 0.25 μm technology, was designed. The concept was at the first validated with electrical and post-layout simulations. The detection system is capable of achieving, in low injection mode, the required performance regarding the detection sensitivity (in the order of 2 ppm), which makes it possible to detect and characterize with precision the dielectric properties of biological cells. A dedicated measurement bench have been developed once the prototype manufactured in order to characterize the circuit. Experiments have demonstrated that the proposed circuit presents promising measurement results with a good agreement with simulations. This demonstrates the high potential of the proposed approach, which make it possible to detect and measure differences between biological elements in a non-invasive way.
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Submitted on : Thursday, September 10, 2020 - 10:40:10 AM
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Meissa Babay. Etude de nouvelles architectures de laboratoires sur puces hyperfréquences intégrées sur CMOS pour les applications biomédicales. Electronique. Université de Limoges, 2020. Français. ⟨NNT : 2020LIMO0016⟩. ⟨tel-02935203⟩

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