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Apport d'une approche translationnelle dans l'étude du lien entre flexibilité cognitive et compulsion : une étude comportementale trans-espèces

Abstract : Obsessive-compulsive disorder (OCD) is characterized by obsessions (intrusive ideas) and compulsions (repetitive behaviors performed through rigid rituals). This phenomenological observation has led to explore the idea that OCD patients have an impaired cognitive flexibility (i.e. ability to change one’s behavior according to contextual cues). Thus, our objective was twofold: to test the hypothesis of an impaired cognitive flexibility underlying compulsive behaviors and to explore their neurobiological bases in patients and an animal model of compulsion, the Sapap3 KO mice. We thus developed a similar reversal learning task in both species, and observed that only a subgroup of compulsive subjects in both species were impaired. This impairment did not result in a greater perseveration after reversal, but in a greater response lability in reversal condition. Moreover, this impairment did not correlate with the severity of compulsive behaviors. The next step in this work was to explore the neural bases of cognitive flexibility and its link with compulsion by modulating cortico-subthalamic circuits in both patients (by deep brain stimulation) and Sapap3 KO mice (by pharmacological modulation and optogenetic stimulation) during task completion. Although still preliminary, the first observations are suggestive of a cognitive flexibility impairment, as measured in our task, as an independent trait.
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  • HAL Id : tel-02932149, version 1

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Nabil Benzina. Apport d'une approche translationnelle dans l'étude du lien entre flexibilité cognitive et compulsion : une étude comportementale trans-espèces. Neurosciences [q-bio.NC]. Sorbonne Université, 2019. Français. ⟨NNT : 2019SORUS183⟩. ⟨tel-02932149⟩

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