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Control of the cerebral cortex plasticity through the non-cell autonomous function of OTX2 homeoprotein

Abstract : During postnatal development, the cerebral cortex has limited temporal periods of high plasticity, called critical periods (CPs). These windows, which allow neural circuitry to be shaped by external stimuli, are found in many cortical regions and are regulated by several factors that influence the balance between excitation and inhibition. The most studied CP is that of ocular dominance in the visual cortex, and the OTX2 homeoprotein transcription factor plays an essential role. OTX2 is transferred from extra-cortical sources into a specific class of interneurons, the parvalbumin (PV) cells, and this transfer controls CP onset and closure in several cortical regions. The aim of my thesis was to reveal the mechanisms underlying OTX2 non-cell autonomous activity implicated in CP regulation. Altogether my work extends our current understanding of cortical plasticity and the role of OTX2 during CPs. I have shown that non-cell autonomous OTX2 regulates cortical postnatal plasticity through direct transcriptional mechanisms and epigenetic modifications.
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  • HAL Id : tel-02931839, version 1

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Jessica Apulei. Control of the cerebral cortex plasticity through the non-cell autonomous function of OTX2 homeoprotein. Neurons and Cognition [q-bio.NC]. Sorbonne Université, 2019. English. ⟨NNT : 2019SORUS451⟩. ⟨tel-02931839⟩

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