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Perturbation de la rythmicité circadienne : impact sur la fonction reproductive de souris femelles

Abstract : In female mammals, cycles in reproductive function depend on both a biological clock synchronized to the light/dark cycle, and a balance between the negative and positive feedbacks of estradiol which concentration varies during ovary maturation. In women, studies report that chronodisruptive environments, notably those experienced in shiftwork conditions, may impair fertility and gestational success. The objective of this study was to explore, in female mice, the effects of shifted light/dark cycles on both the robustness of the estrous cycles and the timing of the preovulatory luteinizing hormone (LH) surge, two hallmarks of mammalian reproductive health. When mice were exposed to a single 10 h-phase advance or 10 h-phase delay, the occurrence and timing of the LH surge and estrous cyclicity were recovered at the third estrous cycle. By contrast, when mice were exposed to a chronic shift (successive rotations of 10 h-phase advance for 3 days followed by 10 h-phase delay for 4 days), they exhibited a severely impaired reproductive activity. Most mice had no preovulatory LH surge already at the beginning of the chronic shift. Furthermore, the gestational success of mice exposed to a chronic shift was reduced since the number of pups was two times lower in shifted as compared to control mice. In conclusion, this study reports that female mice exposure to a single-phase shift has minor reproductive effects whereas exposure to chronically disrupted light/dark cycles markedly impairs the preovulatory LH surge occurrence, leading to reduced fertility
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Submitted on : Wednesday, September 2, 2020 - 10:15:08 AM
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  • HAL Id : tel-02927922, version 1

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Thibault Bahougne. Perturbation de la rythmicité circadienne : impact sur la fonction reproductive de souris femelles. Neurosciences [q-bio.NC]. Université de Strasbourg, 2020. Français. ⟨NNT : 2020STRAJ001⟩. ⟨tel-02927922⟩

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