Skip to Main content Skip to Navigation
Theses

Evaluation, prévention et perception des risques en santé environnementale - Réflexions à propos de l'exposition des femmes enceintes aux phtalates et substituts

Abstract : In utero exposure to chemicals, especially endocrine disruptors, is increasingly documented in the scientific literature. This thesis is illustrated through the example of phthalates and substitutes. Phthalates, commonly used as plasticizers to soften polyvinyl chloride (PVC), are present in many consumer products (food packaging, toys, floor and wall coverings, clothing, etc.). They are also used in cosmetics, household products, DIY and gardening. In utero exposure to certain phthalates has been associated with some effects (fetal hormonal alteration, malformations of the male reproductive system, prematurity) [Article 1]. This toxicity has led manufacturers to use alternative plasticizers. However, these substitutes are still little investigated in terms of exposure and toxicity. Part 1 of this thesis is part of the health risk assessment process. It concerned the use of PVC medical tubing, source of exposure to plasticizers little studied for pregnant women. The objectives were to identify and quantify the plasticizers (phthalates and substitutes) present in the medical devices used for hospitalized pregnant women and to describe the use of these medical devices (number, duration of use and medicines in contact) [Article 2]. These data combined with migration studies (to quantify plasticizers migrating from the tubing to the drug solution) can be used to estimate the theoretical exposure of pregnant women from the use of medical tubing. Part 2 focuses on environmental health prevention and promotion. Several international organizations have recently issued recommendations for health professionals and recognize their essential role in the prevention of pregnant women. The objectives were to assess the risk perception and preventive measures in environmental health, including exposure to phthalates, recommended by perinatal health professionals [Articles 3 and 4], and adopted by pregnant women [Article 5]. These data allowed to identify the levers and obstacles to the prevention of exposure to chemical substances in France. Keywords: , , ,
Document type :
Theses
Complete list of metadatas

https://tel.archives-ouvertes.fr/tel-02925877
Contributor : Abes Star :  Contact
Submitted on : Monday, August 31, 2020 - 9:34:25 AM
Last modification on : Tuesday, September 1, 2020 - 3:30:24 AM

File

2017CLFAS019_MARIE.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-02925877, version 1

Collections

Citation

Cécile Marie. Evaluation, prévention et perception des risques en santé environnementale - Réflexions à propos de l'exposition des femmes enceintes aux phtalates et substituts. Médecine humaine et pathologie. Université Clermont Auvergne, 2017. Français. ⟨NNT : 2017CLFAS019⟩. ⟨tel-02925877⟩

Share

Metrics

Record views

53

Files downloads

16