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Etude de l'implication de la fonction vestibulaire dans la rythmicité biologique chez l'Homme

Abstract : The main objective of this thesis was to test if the vestibular stimulation can impact the circadian biological rhythms in human. We have evaluated the effects of two vestibular stimulation methods (rotatory chair, Galvanic Vestibular Stimulation/GVS) on the motor activity rhythm of young healthy adults. This project also evaluated tolerability of the stimulation protocols. The similarities between GVS and transcranial Direct Current Stimulation (tDCS) used in the treatment of depression, and the links between biological rhythms disorders and mood disorders, have led us to assess the effects of vestibular stimulation on the anxiety level.Effects of vestibular stimulation induced by a rotatory chair at the end of the afternoon has been tested in the first study. We observed a decrease in motor activity level after the vestibular stimulation, and a phase advance effect two days after the stimulation. The second study demonstrated no significant effects of the GVS applied in the middle of the day on the motor activity rhythm, and the wake/sleep transition. Finally, the third study showed that GVS can decrease the anxiety level. This effect depends on the stimulation parameters (duration). GVS method was well tolerated by the participants. On the contrary, the rotatory chair induced motion sickness symptoms.These results confirm the influence of vestibular stimulation on biological rhythms and mood in human. However, the observed effects depend on the stimulation parameters (technique, time of the day). These results promote studies about the use of vestibular stimulation in the regulation of biological rhythms, and the GVS in the treatment of the biological rhythms and mood disorders.
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Submitted on : Tuesday, August 25, 2020 - 10:13:16 AM
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Florane Pasquier. Etude de l'implication de la fonction vestibulaire dans la rythmicité biologique chez l'Homme. Education. Normandie Université, 2020. Français. ⟨NNT : 2020NORMC201⟩. ⟨tel-02921377⟩

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