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MRI analysis of brain connectivity in a mouse model of Alzheimer’s disease

Abstract : Alzheimer’s disease (AD) is the most widespread dementia in the world, presenting progressive memory impairment. Using resting-state MRI, in both human and animal studies, has opened a new window into the brain and its connectome, proposing abnormal functional connectivity as a candidate biomarker of brain pathologies such as AD. We investigated the connectome’s affectation over time in vivo in a longitudinal study, to follow-up and characterize a transgenic mouse model of AD, combining both functional and structural approaches and evaluating possible network signatures of pathological states. We associate behavioral assessment and histological staining of neurotoxic protein to the MRI approach, in order to relate pathological mechanism, at both network and cellular level, to memory dysfunction. We found remarkable structural and functional modifications, mediating prodromal alterations of the memory system, before the beginning of memory impairment. Considerable changes in the septal connectivity particularly towards limbic centers but also involving communication with the Default Mode Network were highlighted over time. These vulnerable circuits represent biomarkers of the disease and potential targets for future treatment.
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  • HAL Id : tel-02918203, version 1

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Laetitia Degiorgis. MRI analysis of brain connectivity in a mouse model of Alzheimer’s disease. Neurons and Cognition [q-bio.NC]. Université de Strasbourg, 2019. English. ⟨NNT : 2019STRAD025⟩. ⟨tel-02918203⟩

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