Skip to Main content Skip to Navigation
Theses

Synthèse de nouveaux agents anticancéreux

Abstract : Cancers represent a major public health problem hence the need to use new classes of medicines. Among the opportunities for developing new treatments, two have caught our attention and that of our collaborators: the modulation of splicing by compounds such as NVS-SM2, and the inhibition of the oncogene KRAS by derivatives of natural products, the flavaglines.In this context, we have developed the first robust synthesis of NVS-SM2, which can satisfy the global demand of this agent to examine in detail its therapeutic potential in different types of disorders. In addition, the synthetic strategy reported here could be extended to new analogues of this compound. Furthermore, we have synthesized new flavaglines that have been examined for their effects on KRAS inhibition. During this study, we discovered new reactions, including a dimethylcarbamoyl chloride-induced amine inversion of configuration.
Document type :
Theses
Complete list of metadatas

Cited literature [225 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-02918197
Contributor : Abes Star :  Contact
Submitted on : Thursday, August 20, 2020 - 10:57:23 AM
Last modification on : Wednesday, September 23, 2020 - 3:10:09 PM

File

Abou-Hamdan_Hussein_2018_ED222...
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-02918197, version 1

Collections

Citation

Hussein Abou Hamdan. Synthèse de nouveaux agents anticancéreux. Sciences pharmaceutiques. Université de Strasbourg, 2018. Français. ⟨NNT : 2018STRAF012⟩. ⟨tel-02918197⟩

Share

Metrics

Record views

47

Files downloads

69