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Rétrovirus endogènes humains et réponse immunitaire de l’hôte suite à une agression inflammatoire

Abstract : Following inflammatory injury, like a septic shock, severe burn or important trauma, the immune system responds by a massive modulation of its transcriptome in the blood. We propose to explore another repertoire than gene expression and to focus on repeated elements, especially on HERVs. They represent more than 8% of the human genome. HERVs are expressed in similar settings (cancer or auto-immune diseases) and impact immune response. In this project, we describe and aim to better understand the HERV contribution in host immune response, following inflammatory aggression. To bring elements of response, we developed specifically dedicated tools to describe the HERVome, either at genomic or transcriptomic level. We show HERVs are expressed in blood in these settings, modulated in patients and could play a role on nearby gene expression. We also evaluate the polymorphism of presence of HERV loci on more than two thousands individuals, grouped into human populations. We show an important HERV polymorphism, that it is population-specific, and that some loci are absent in the majority of the analyzed genomes.Finally, with different approaches, we identify associations between immune-response genes and HERVs, suggesting these elements can play a role in host immune response following inflammatory aggressions
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https://tel.archives-ouvertes.fr/tel-02918174
Contributor : Abes Star :  Contact
Submitted on : Thursday, August 20, 2020 - 10:51:33 AM
Last modification on : Tuesday, October 20, 2020 - 11:30:13 AM

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  • HAL Id : tel-02918174, version 1

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Olivier Tabone. Rétrovirus endogènes humains et réponse immunitaire de l’hôte suite à une agression inflammatoire. Bio-informatique [q-bio.QM]. Université de Lyon, 2019. Français. ⟨NNT : 2019LYSE1015⟩. ⟨tel-02918174⟩

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