Interleukins 1? and 6 but not transforming growth factor-? are essential for the differentiation of interleukin 17-producing human T helper cells, Nat Immunol, vol.8, pp.942-949, 2007. ,
Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells, Nat Immunol, vol.8, pp.639-646, 2007. ,
, , 2003.
, Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17, J Biol Chem, vol.278, pp.1910-1914
Lack of Ikaros cripples expression of Foxo1 and its targets in naive T cells, Immunology, vol.152, pp.494-506, 2017. ,
Ikaros is expressed in developing striatal neurons and involved in enkephalinergic differentiation: Ikaros in striatal development, J Neurochem, vol.102, pp.1805-1816, 2007. ,
Thymopoiesis independent of common lymphoid progenitors, Nat Immunol, vol.4, pp.168-174, 2003. ,
Ikaros is required for plasmacytoid dendritic cell differentiation, Blood, vol.108, pp.4025-4034, 2006. ,
URL : https://hal.archives-ouvertes.fr/hal-00165590
Phenotypic and functional features of human Th17 cells, J Exp Med, vol.204, pp.1849-1861, 2007. ,
Sumoylation Inhibits the Growth Suppressive Properties of Ikaros, PLoS One, vol.11, 2016. ,
12, IL-17, and IL-18 in Patients With Active Psoriasis and Correlation With Disease Severity, Serum Levels of TNF-? , IFN-?, pp.273-279, 2005. ,
Ikaros sets thresholds for T cell activation and regulates chromosome propagation, Immunity, vol.10, pp.333-343, 1999. ,
A noninvasive genetic/pharmacologic strategy for visualizing cell morphology and clonal relationships in the mouse, J Neurosci, vol.23, pp.2314-2322, 2003. ,
E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas, Mol Cell Biol, vol.17, pp.4782-4791, 1997. ,
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease, Nat Genet, vol.40, pp.955-962, 2008. ,
A thymic precursor to the NK T cell lineage, Science, vol.296, pp.553-555, 2002. ,
Characterization of the early stages of thymic NKT cell development, J Exp Med, vol.202, pp.485-492, 2005. ,
Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus, Nat Genet, vol.47, pp.1457-1464, 2015. ,
Loss of T-bet, But Not STAT1, Prevents the Development of Experimental Autoimmune Encephalomyelitis, J Exp Med, vol.200, pp.79-87, 2004. ,
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells, Nature, vol.441, pp.235-238, 2006. ,
Lack of natural killer cell precursors in fetal liver of Ikaros knockout mutant mice, Nat Immun, vol.16, pp.137-145, 1998. ,
, , 2012.
, Réponses immunitaires au cours des MICI : implication de l'axe IL-23/Th17, Hépato Gastro, vol.19, pp.446-454
Direct Protein Interactions Are Responsible for Ikaros-GATA and Ikaros-Cdk9 Cooperativeness in Hematopoietic Cells, Mol Cell Biol, vol.33, pp.3064-3076, 2013. ,
A2 T cell subsets and T cellmediated immunity, Principles of Immunopharmacology, pp.15-27, 2011. ,
, , 1997.
, Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin, Cell, vol.91, pp.845-854
The development of inflammatory TH-17 cells requires interferonregulatory factor 4, Nat Immunol, vol.8, pp.958-966, 2007. ,
Computational modeling of heterogeneity and function of CD4+ T cells, Front Cell Dev Biol, vol.2, p.31, 2014. ,
Functional and Phenotypic Plasticity of CD4(+) T Cell Subsets, Biomed Res Int, p.521957, 2015. ,
A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity, Nature, vol.457, pp.722-725, 2009. ,
Stat3 and Gfi-1 Transcription Factors Control Th17 Cell Immunosuppressive Activity via the Regulation of Ectonucleotidase Expression, Immunity, vol.36, pp.362-373, 2012. ,
URL : https://hal.archives-ouvertes.fr/inserm-00821485
Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1-NKT cell population, Proc Natl Acad Sci U S A, vol.105, pp.11287-11292, 2008. ,
, Th17 cells: new players in asthma pathogenesis: T lymphocytes and asthma phenotypes, vol.66, pp.989-998, 2011.
Follicular helper CD4 T cells (TFH), Annu Rev Immunol, vol.29, pp.621-663, 2011. ,
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain, Nature, vol.421, pp.744-748, 2003. ,
IL-4 inhibits TGF-?induced Foxp3+ T cells and, together with TGF-?, generates IL-9+ IL-10+ Foxp3? effector T cells, Nat Immunol, vol.9, pp.1347-1355, 2008. ,
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression, J Exp Med, vol.204, pp.1257-1265, 2007. ,
Dichotomy between naïve and memory CD4(+) T cell responses to Fas engagement, Proc Natl Acad Sci U S A, vol.96, pp.8104-8109, 1999. ,
Ikaros, CK2 kinase, and the road to leukemia, Mol Cell Biochem, vol.356, pp.201-207, 2011. ,
Associations between serum interleukin-23 levels and clinical characteristics in patients with systemic lupus erythematosus, J Int Med Res, vol.42, pp.1123-1130, 2014. ,
IL-17+Foxp3+ T cells: an intermediate differentiation stage between Th17 cells and regulatory T cells, J Leukoc Biol, vol.96, pp.39-48, 2014. ,
Notch Activation Is an Early and Critical Event during T-Cell Leukemogenesis in Ikaros-Deficient Mice, Mol Cell Biol, vol.26, pp.209-220, 2006. ,
URL : https://hal.archives-ouvertes.fr/hal-00187901
Biclonal and biallelic deletions occur in 20% of B-ALL cases with IKZF1 mutations, Leukemia, vol.27, pp.503-507, 2013. ,
CD39 and control of cellular immune responses, Purinergic Signal, vol.3, pp.171-180, 2007. ,
An essential function for the nuclear receptor ROR?t in the generation of fetal lymphoid tissue inducer cells, Nat Immunol, vol.5, pp.64-73, 2004. ,
The encephalitogenicity of TH17 cells is dependent on IL-1-and IL-23-induced production of the cytokine GM-CSF, Nat Immunol, vol.12, pp.568-575, 2011. ,
Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway, Blood, vol.111, pp.1013-1020, 2008. ,
An essential role for the hematopoietic transcription factor Ikaros in hypothalamic-pituitary-mediated somatic growth, Proc Natl Acad Sci U S A, vol.103, pp.2214-2219, 2006. ,
Expansion of Th17 Cells and Functional Defects in T Regulatory Cells Are Key Features of the Pancreatic Lymph Nodes in Patients With Type 1 Diabetes, Diabetes, vol.60, pp.2903-2913, 2011. ,
Regulation of Gut Inflammation and Th17 Cell Response by Interleukin-21, Gastroenterology, vol.134, pp.1038-1048, 2008. ,
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation, J Exp Med, vol.192, pp.1027-1034, 2000. ,
Increased expression of interleukin 17 in inflammatory bowel disease, Gut, vol.52, pp.65-70, 2003. ,
Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation, Nature, vol.523, pp.221-225, 2015. ,
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus, Nat Genet, vol.41, pp.1228-1233, 2009. ,
, Plasticity of Human CD4 T Cell Subsets. Front Immunol 5, p.630, 2014.
The Tumor Suppressor Ikaros Shapes the Repertoire of Notch Target Genes in T Cells, Sci Signal, vol.7, p.28, 2014. ,
Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment, Science, vol.258, pp.808-812, 1992. ,
, , 1994.
, The Ikaros gene is required for the development of all lymphoid lineages, Cell, vol.79, pp.143-156
Generation of pathogenic TH17 cells in the absence of TGF-? signaling, Nature, vol.467, pp.967-971, 2010. ,
Cutting Edge: IL-17-Secreting Innate Lymphoid Cells Are Essential for Host Defense against Fungal Infection, J Immunol, vol.190, pp.521-525, 2013. ,
Evidence for STAT4 as a Common Autoimmune Gene: rs7574865 Is Associated with Colonic Crohn's Disease and Early Disease Onset, PLoS One, vol.5, 2010. ,
A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8-triple-negative adult mouse thymocytes defined by CD44 and CD25 expression, J Immunol, vol.150, pp.4244-4252, 1993. ,
Phosphorylation controls Ikaros's ability to negatively regulate the G(1)-S transition, Mol Cell Biol, vol.24, p.2807, 2004. ,
Frequency and functional activity of Th17, Tc17 and other T-cell subsets in Systemic Lupus Erythematosus, Cell Immunol, vol.264, pp.97-103, 2010. ,
Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model, J Exp Med, vol.204, pp.2803-2812, 2007. ,
Fate mapping of IL-17-producing T cells in inflammatory responses, Nat Immunol, vol.12, pp.255-263, 2011. ,
Plasticity of TH17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses, Nat Immunol, vol.14, pp.372-379, 2013. ,
IL-17 Immunity in Human Type 1 Diabetes, J Immunol, vol.185, pp.1959-1967, 2010. ,
Abnormal hematopoiesis and autoimmunity in human subjects with germline IKZF1 mutations, J Allergy Clin Immunol, vol.140, pp.223-231, 2017. ,
Superenhancer reprogramming drives a B-cell-epithelial transition and high-risk leukemia, Genes Dev, vol.30, pp.1971-1990, 2016. ,
A Th17-like developmental process leads to CD8(+) Tc17 cells with reduced cytotoxic activity, Eur J Immunol, vol.39, pp.1716-1725, 2009. ,
Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow, Immunity, vol.17, pp.117-130, 2002. ,
Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation, Proc Natl Acad Sci U S A, vol.89, pp.1502-1506, 1992. ,
The Orphan Nuclear Receptor ROR?t Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells, Cell, vol.126, pp.1121-1133, 2006. ,
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria, Cell, vol.139, pp.485-498, 2009. ,
Th1, Th17, and Th9 Effector Cells Induce Experimental Autoimmune Encephalomyelitis with Different Pathological Phenotypes, J Immunol, vol.183, pp.7169-7177, 2009. ,
, , 2010.
, Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL, Blood, vol.116, pp.5443-5454
Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo, J Exp Med, vol.165, pp.302-319, 1987. ,
Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo, Nat Genet, vol.44, pp.676-680 ,
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease, Nature, vol.491, pp.119-124, 2012. ,
T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression, Mol Cell Biol, vol.7, pp.4472-4481, 1987. ,
A Molecular Dissection of the Repression Circuitry of Ikaros, J Biol Chem, vol.277, pp.27697-27705, 2002. ,
Identification of clonogenic common lymphoid progenitors in mouse bone marrow, Cell, vol.91, pp.661-672, 1997. ,
Th17 cells: Effector T cells with inflammatory properties, Semin Immunol, vol.19, pp.362-371, 2007. ,
Alagille syndrome: chipping away at the tip of the iceberg, Am J Med Genet, vol.112, pp.160-162, 2002. ,
T-bet is a key modulator of IL-23-driven pathogenic CD4+ T cell responses in the intestine, Nat Commun, vol.7, p.11627, 2016. ,
Endogenous IL-17 contributes to reduced tumor growth and metastasis, Blood, vol.114, pp.357-359, 2009. ,
Loss of B Cells in Patients with Heterozygous Mutations in IKAROS, N Engl J Med, vol.374, pp.1032-1043, 2016. ,
Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr mice, J Immunol, vol.184, pp.4605-4609, 2010. ,
A new analysis of allogeneic interactions, Aust J Exp Biol Med Sci, vol.53, pp.27-42, 1975. ,
, , 2015.
, Foxo1 Is a T Cell-Intrinsic Inhibitor of the ROR?t-Th17 Program, J Immunol, vol.195, pp.1791-1803
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation, J Exp Med, vol.201, pp.233-240, 2005. ,
Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation, Immunity, vol.26, pp.371-381, 2007. ,
Induction and molecular signature of pathogenic TH17 cells, Nat Immunol, vol.13, pp.991-999, 2012. ,
Developmental plasticity of Th17 and Treg cells, Curr Opin Immunol, vol.21, pp.274-280, 2009. ,
, T Cell-Produced Transforming Growth Factor-?1, 2007.
, Controls T Cell Tolerance and Regulates Th1-and Th17-Cell Differentiation, vol.26, pp.579-591
Ikaros isoforms: The saga continues, World J Biol Chem, vol.2, pp.140-145, 2011. ,
A high-resolution map of transcriptional repression, ELife, vol.6, p.22767, 2017. ,
T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1, Proc Natl Acad Sci U S A, vol.87, pp.5031-5035, 1990. ,
A regulatory effect of IL-21 on T follicular helper-like cell and B cell in rheumatoid arthritis, Arthritis Res Ther, vol.14, p.255, 2012. ,
LyF-1, a transcriptional regulator that interacts with a novel class of promoters for lymphocyte-specific genes, Mol Cell Biol, vol.11, pp.5229-5243, 1991. ,
CD4?T cells: differentiation and functions, Clin Dev Immunol, 2012. ,
Integrative biology of T cell activation, Nat Immunol, vol.15, pp.790-797, 2014. ,
Transforming growth factor-? induces development of the TH17 lineage, Nature, vol.441, pp.231-234, 2006. ,
Genetic inactivation of Ikaros is a rare event in human T-ALL, Leuk Res, vol.34, pp.426-429, 2010. ,
Meta-analysis identifies seven susceptibility loci involved in the atopic march, Nat Commun, vol.6, p.8804, 2015. ,
Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation, Nat Immunol, vol.10, pp.1125-1132, 2009. ,
Controversies on the role of Th17 in cancer: a TGF?-dependent immunosuppressive activity?, Trends Mol Med, vol.18, pp.742-749, 2012. ,
T Helper 17 Cells Promote Cytotoxic T Cell Activation in Tumor Immunity, Immunity, vol.31, pp.787-798, 2009. ,
T cell lineage determination precedes the initiation of TCR beta gene rearrangement, J Immunol, vol.179, pp.3699-3706, 2007. ,
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo, Nat Immunol, vol.10, pp.314-324, 2009. ,
STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE, J Neuroinflammation, vol.12, p.128, 2015. ,
Critical role of ROR-t in a new thymic pathway leading to IL-17-producing invariant NKT cell differentiation, Proc Natl Acad Sci U S A, vol.105, 2008. ,
The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins, Mol Cell Biol, vol.14, pp.8292-8303, 1994. ,
Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation, EMBO J, vol.16, pp.2004-2013, 1997. ,
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins, J Immunol, vol.136, pp.2348-2357, 1986. ,
, , 2007.
, Cell Differentiation Mediated by Retinoic Acid. Science, vol.317, pp.256-260
Deletion of IKZF1 and Prognosis in Acute Lymphoblastic Leukemia, N Engl J Med, vol.360, pp.470-480, 2009. ,
Divergent Pro-and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation, J Exp Med, vol.198, pp.1951-1957, 2003. ,
Genome-wide Lineage-Specific Transcriptional Networks Underscore Ikaros-Dependent Lymphoid Priming in Hematopoietic Stem Cells, vol.30, pp.493-507, 2009. ,
Defects in hemopoietic stem cell activity in Ikaros mutant mice, J Exp Med, vol.190, pp.1201-1214, 1999. ,
Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment, Proc Natl Acad Sci U S A, vol.107, pp.14751-14756, 2010. ,
Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells, J Exp Med, vol.205, pp.2491-2497, 2008. ,
Interleukin-17 promotes angiogenesis and tumor growth, Blood, vol.101, pp.2620-2627, 2003. ,
IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis, J Immunol, vol.175, pp.6177-6189, 2005. ,
Ikaros Imposes a Barrier to CD8+ T Cell Differentiation by Restricting Autocrine IL-2 Production, J Immunol, vol.192, pp.5118-5129, 2014. ,
A transgenic mouse model of human T cell leukemia virus type 1-associated diseases, Front Microbiol, vol.4, p.49, 2013. ,
New regulatory co-receptors: inducible co-stimulator and PD-1, Curr Opin Immunol, vol.14, pp.779-782, 2002. ,
Novel p19 protein engages IL-12p40 to form a cytokine, Immunity, vol.13, issue.23, pp.715-725, 2000. ,
Ikaros mediates gene silencing in T cells through Polycomb repressive complex 2, Nat Commun, vol.6, p.8823, 2015. ,
Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor, Immunity, vol.19, pp.131-144, 2003. ,
IL-17+ ?? T cells as kick-starters of inflammation, Nat Immunol, vol.18, pp.604-611, 2017. ,
Signaling by members of the TGF-? family in vascular morphogenesis and disease, Trends Cell Biol, vol.20, pp.556-567, 2010. ,
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17, Nat Immunol, vol.6, pp.1133-1141, 2005. ,
TWEAK promotes the production of Interleukin-17 in rheumatoid arthritis, Cytokine, vol.60, pp.143-149, 2012. ,
Ikaros isoform x is selectively expressed in myeloid differentiation, J Immunol, vol.170, pp.3091-3098, 2003. ,
An Ikaros Promoter Element with Dual Epigenetic and Transcriptional Activities, PLoS One, vol.10, 2015. ,
Heterogeneity among DN1 prothymocytes reveals multiple progenitors with different capacities to generate T cell and non-T cell lineages, Immunity, vol.20, pp.735-745, 2004. ,
Notch1 expression in early lymphopoiesis influences B versus T lineage determination, Immunity, vol.11, pp.299-308, 1999. ,
Angels and demons: Th17 cells represent a beneficial response, while neutrophil IL-17 is associated with poor prognosis in squamous cervical cancer, Oncoimmunology, vol.4, p.984539, 2015. ,
Aiolos promotes TH17 differentiation by directly silencing Il2 expression, Nat Immunol, vol.13, pp.770-777, 2012. ,
Cutting edge: Ikaros is a regulator of Th2 cell differentiation, J Immunol, vol.182, pp.741-745, 2009. ,
,
, Deficient T cell fate specification in mice with an induced inactivation of Notch1, Immunity, vol.10, pp.547-558
Integrated STAT3 and Ikaros Zinc Finger Transcription Factor Activities Regulate Bcl-6 Expression in CD4 + Th Cells, J Immunol, vol.199, pp.2377-2387, 2017. ,
IL-3 promotes the development of experimental autoimmune encephalitis, JCI Insight, vol.1, p.87157, 2016. ,
The SWI/SNF complex -chromatin and cancer, Nat Rev Cancer, vol.4, pp.133-142, 2004. ,
Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub, Nat Immunol, vol.15, pp.384-392, 2014. ,
Differential regulation of interleukin 17 and interferon production in inflammatory bowel disease, Gut, vol.58, pp.1629-1636, 2009. ,
Regulatory T Cells and Immune Tolerance, Cell, vol.133, pp.775-787, 2008. ,
Lineage Relationship Analysis of ROR t+ Innate Lymphoid Cells, Science, vol.330, pp.665-669, 2010. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01402753
Neuroaxonal Regeneration is More Pronounced in Early Multiple Sclerosis than in Traumatic Brain Injury Lesions: Neuroaxonal De-and Regeneration in MS and TBI, Brain Pathol, vol.23, pp.2-12, 2013. ,
Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros, Nat Immunol, vol.14, pp.1073-1083, 2013. ,
Mechanisms of TGF-?-mediated apoptosis, Cell Tissue Res, vol.307, pp.1-14, 2002. ,
Ikaros controls isotype selection during immunoglobulin class switch recombination, J Exp Med, vol.206, pp.1073-1087, 2009. ,
URL : https://hal.archives-ouvertes.fr/inserm-00387911
Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus, Arthritis Res Ther, vol.12, p.53, 2010. ,
STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflammation, Cell Res, vol.24, pp.1387-1402, 2014. ,
Regulatory T cells suppress CD4+ T cells through NFAT-dependent transcriptional mechanisms, EMBO Rep, vol.15, pp.991-999, 2014. ,
Regulating functional cell fates in CD8 T cells, Immunol Res, vol.46, pp.12-22, 2010. ,
Intratumoral cytokines/chemokines/growth factors and tumor infiltrating dendritic cells: friends or enemies?, Cancer Metastasis Rev, vol.25, pp.333-356, 2006. ,
Complementary signaling through flt3 and Interleukin-7 Receptor ? Is Indispensable for Fetal and Adult B Cell Genesis, J Exp Med, vol.198, pp.1495-1506, 2003. ,
DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites, Mol Cell Biol, vol.20, pp.389-401, 2000. ,
Purification and characterization of mouse hematopoietic stem cells, Science, vol.241, pp.58-62, 1988. ,
The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling, Nat Immunol, vol.12, pp.21-27, 2011. ,
Foxo3 Transcription Factor Drives Pathogenic T Helper 1 Differentiation by Inducing the Expression of Eomes, Immunity, vol.45, pp.774-787, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-02631699
The dichotomous nature of T helper 17 cells, Nat Rev Immunol, 2017. ,
Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development, EMBO J, vol.15, pp.5358-5369, 1996. ,
Regulation of T Helper 17 Differentiation by Orphan Nuclear Receptors: It's Not Just ROR?t Anymore, Immunity, vol.28, pp.5-7, 2008. ,
An Allele of IKZF1 (Ikaros) Conferring Susceptibility to Childhood Acute Lymphoblastic Leukemia Protects Against Type 1 Diabetes, Diabetes, vol.60, pp.1041-1044, 2011. ,
A novel transcription factor, T-bet, directs Th1 lineage commitment, Cell, vol.100, pp.655-669, 2000. ,
The Role of IL-17 and Th17 Lymphocytes in Autoimmune Diseases, Arch Immunol Ther Exp (Warsz), vol.63, pp.435-449, 2015. ,
Developmental and molecular characterization of emerging beta-and gammadelta-selected pre-T cells in the adult mouse thymus, Immunity, vol.24, pp.53-64, 2006. ,
Finger protein of novel structure encoded by hunchback, a second member of the gap class of Drosophila segmentation genes, Nature, vol.327, pp.383-389, 1987. ,
Ikaros Silences T-bet Expression and Interferon-? Production during T Helper 2 Differentiation, J Biol Chem, vol.285, pp.2545-2553, 2010. ,
Ikaros Is a Regulator of Il10 Expression in CD4+ T Cells, J Immunol, vol.183, pp.5518-5525, 2009. ,
Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP, Cell, vol.79, pp.901-912, 1994. ,
Interleukin-17 in inflammatory skin disorders, Curr Opin Allergy Clin Immunol, vol.7, pp.374-381, 2007. ,
IL-17/Th17 mediated synovial inflammation is IL-22 independent, Ann Rheum Dis, vol.72, pp.1700-1707, 2013. ,
TCR Signal Strength Alters T-DC Activation and Interaction Times and Directs the Outcome of Differentiation, Front Immunol, vol.7, p.6, 2016. ,
Th9 Cells: A Novel CD4 T-cell Subset in the Immune War against Cancer, Cancer Res, vol.75, pp.475-479, 2015. ,
TGF? in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells, Immunity, vol.24, pp.179-189, 2006. ,
Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin-9 producing subset, Nat Immunol, vol.9, pp.1341-1346, 2008. ,
CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen, J Immunol, vol.164, pp.2978-2986, 2000. ,
Interleukin-17-secreting T cells in neuromyelitis optica and multiple sclerosis during relapse, J Clin Neurosci, vol.18, pp.1313-1317, 2011. ,
Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation, Immunity, vol.5, pp.537-549, 1996. ,
Development, cytokine profile and function of human interleukin 17-producing helper T cells, Nat Immunol, vol.8, pp.950-957, 2007. ,
A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma, Cell, vol.83, pp.289-299, 1995. ,
Ikaros Sets the Potential for Th17 Lineage Gene Expression through Effects on Chromatin State in Early T Cell Development, J Biol Chem, vol.288, pp.35170-35179, 2013. ,
Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny, J Exp Med, vol.184, pp.903-911, 1996. ,
Cell-autonomous defects in dendritic cell populations of Ikaros mutant mice point to a developmental relationship with the lymphoid lineage, Immunity, vol.7, pp.483-492, 1997. ,
Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo, J Exp Med, vol.209, pp.1713-1722, 2012. ,
IL-21 and TGF-? are required for differentiation of human TH17 cells, Nature, vol.454, pp.350-352, 2008. ,
STAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells, J Biol Chem, vol.282, pp.9358-9363, 2007. ,
The Role and Regulation of Human Th17 Cells in Tumor Immunity, Am J Pathol, vol.182, pp.10-20, 2013. ,
, Tc17 CD8 T Cells: Functional Plasticity and Subset Diversity, vol.183, pp.7161-7168, 2009.
Dynamic regulatory network controlling TH17 cell differentiation, Nature, vol.496, pp.461-468, 2013. ,
Awakening lineage potential by Ikaros-mediated transcriptional priming, Curr Opin Immunol, vol.22, pp.154-160, 2010. ,
Transcriptional regulation of the Ikzf1 locus, Blood, vol.122, pp.3149-3159, 2013. ,
Ikaros fingers on lymphocyte differentiation, Int J Hematol, vol.100, pp.220-229, 2014. ,
Increased Frequencies of Th22 Cells as well as Th17 Cells in the Peripheral Blood of Patients with Ankylosing Spondylitis and Rheumatoid Arthritis, PLoS One, vol.7, p.31000, 2012. ,
The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells, Cell, vol.89, pp.587-596, 1997. ,
IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways, Nat Immunol, vol.8, pp.967-974, 2007. ,
Plasticity of CD4+ T Cell Lineage Differentiation, Immunity, vol.30, pp.646-655, 2009. ,